Special Lab Primate Neurobiology

The special lab Primate Neurobiology provides techniques and know-how that is required for neurobiological research on primates. These include behavioral testing, micro-electrode recordings of neuronal signals, electrical brain stimulation, and implant surgery. In collaboration with other units of the LIN we perform functional magnetic resonance imaging and anatomical reconstructions of the primate brain. The Animal House of the LIN hosts a breeding colony for longtail macaques (Macaca fascicularis).

Most of the research conducted by the special lab is performed in close collaboration with other research units at the LIN and at the Otto-von-Guericke University Magdeburg, which study humans with noninvasive brain imaging techniques. One line of research is part of a collaborative research center with partners at the LIN, the Otto-von-Guericke University Magdeburg, and the Carl von Ossietzky University Oldenburg on 'The Active Auditory System'. Here we aim to unravel neuronal mechanisms in the auditory cortex that underlie the perceptual grouping of tone sequences.

  • Head

    Head

    Michael Brosch studied physics at the Universities of Bielefeld and Marburg. Subsequently, he received his doctorate in physics from the Department of Biophysics at the University of Marburg.

    He then worked as a postdoctoral fellow at the University of California in San Francisco.

    Michael Brosch has been a research associate at LIN since 1995 and habilitated at OVGU in 2006. Since 2009 he has been head of this Special Lab.

  • Members

    Members

    Head  
    Prof. Dr. Michael Brosch+49-391-6263-93481michael.brosch@lin-magdeburg.de
    Postdocs  
    Dr. Ying Huang+49-391-6263-94471ying.huang@lin-magdeburg.de
    PhD students  
    Vighneshvel Thiruppathi+49-391-6263-94481vighneshvel.thiruppathi@lin-magdeburg.de
    Sanchit Rathi+49-391-6263-94471sanchit.rathi@lin-magdeburg.de
  • Projects

    Projects

    One research project investigates how cognitive and motivational elements of auditory tasks are represented in the auditory cortex.

    In collaboration with the special lab Non-invasive Brain Imaging we study neuronal mechanisms of working memory in the auditory cortex that support the ability of humans and nonhuman primates to memorize auditory informtion for a short time.

    Together with the Department for Biometrics and Medical Informatics at the OVGU we developed magnetic coils to improve functional MR imaging of the primate brain in high field.

     

  • Current Third Party Funds

    Current Third Party Funds

    2018-2020
    CBBS Neuronal networks (granted to Dr. Ying Huang)
    "Dopaminergic modulation of working memory-related persistent neuronal activity in auditory cortex: from molecules to behavior"
    www.cbbs.eu

  • Publications

    Publications

    2019

    Huang Y, Lu H, Li L. 2019. Human scalp evoked potentials related to the fusion between a sound source and its simulated reflection. PLoS ONE. 14(1). https://doi.org/10.1371/journal.pone.0209173

     

    2018

    Selezneva E, Gorkin A, Budinger E, Brosch M. 2018. Neuronal correlates of auditory streaming in the auditory cortex of behaving monkeys. European Journal of Neuroscience. Available from: 10.1111/ejn.14098

    Knyazeva S, Selezneva E, Gorkin A, Aggelopoulos NC, Brosch M. 2018. Neuronal correlates of auditory streaming in monkey auditory cortex for tone sequences without spectral differences. Frontiers in Integrative Neuroscience. 12. Available from: 10.3389/fnint.2018.00004

    Herrmann T, Liebig T, Mallow J, Bruns C, Stadler J, Mylius J, Brosch M, Svedja JT, Chen Z, Rennings A, Scheich H, Plaumann M, Hauser MJB, Bernarding J, Erni D. 2018. Metamaterial-based transmit and receive system for whole-body magnetic resonance imaging at ultra-high magnetic fields. PLoS ONE. 13(1). Available from: 10.1371/journal.pone.0191719

     

    2017

    Aggelopoulos NC, Deike S, Selezneva E, Scheich H, Brechmann A, Brosch M. 2017. Predictive cues for auditory stream formation in humans and monkeys. European Journal of Neuroscience. Available from: 10.1111/ejn.13808

    Selezneva E, Oshurkova E, Scheich H, Brosch M. 2017. Category-specific neuronal activity in left and right auditory cortex and in medial geniculate body of monkeys. PLoS ONE. 12(10). Available from: 10.1371/journal.pone.0186556

    Aggelopoulos NC. 2017. Electrical nerve stimulation and central microstimulation. In Neuromethods. Humana Press Inc. pp. 141-153. (Neuromethods). Available from: 10.1007/978-1-4939-6490-1_7

     

    2016

    Huang Y, Matysiak A, Heil P, König R, Brosch M. 2016. Persistent neural activity in auditory cortex is related to auditory working memory in humans and nonhuman primates. eLife. 5(JULY). Available from: 10.7554/eLife.15441

    Kaiser J, Brosch M. 2016. Neural correlates of auditory working memory. Brain Research. 1640:181-182. Available from: 10.1016/j.brainres.2016.04.056

    Huang Y, Mylius J, Scheich H, Brosch M. 2016. Tonic effects of the dopaminergic ventral midbrain on the auditory cortex of awake macaque monkeys. Brain Structure and Function. 221(2):969-977. Available from: 10.1007/s00429-014-0950-2

    Huang Y, Brosch M. 2016. Neuronal activity in primate prefrontal cortex related to goal-directed behavior during auditory working memory tasks. Brain Research. 1640(Pt B):314-327. Available from: 10.1016/j.brainres.2016.02.010

     

    2015

    Mylius J, Happel MFK, Gorkin AG, Huang Y, Scheich H, Brosch M. 2015. Fast transmission from the dopaminergic ventral midbrain to the sensory cortex of awake primates. Brain Structure and Function. 220(6):3273-3294. Available from: 10.1007/s00429-014-0855-0

    Lovell JM, Mylius J, Scheich H, Brosch M. 2015. Stimulation of the dopaminergic midbrain as a behavioral reward in instrumentally conditioned monkeys. Brain Stimulation. 8(5):868-874. Available from: 10.1016/j.brs.2015.04.007

    Aggelopoulos NC. 2015. Perceptual inference. Neuroscience and Biobehavioral Reviews. 55:375-392. Available from: 10.1016/j.neubiorev.2015.05.001

    Herrmann T, Mallow J, Plaumann M, Luchtmann M, Stadler J, Mylius J, Brosch M, Bernarding J. 2015. The travelling-wave Primate System: A new solution for magnetic resonance imaging of macaque monkeys at 7 tesla ultra-high field. PLoS ONE. 10(6). Available from: 10.1371/journal.pone.0129371

    Budinger E, Brechmann A, Brosch M, Heil P, König R, Ohl FW, Scheich H. 2015. Auditory cortex 2014 - towards a synthesis of human and animal research. European Journal of Neuroscience. 41(5):515-517. Available from: 10.1111/ejn.12832

    Brosch M, Selezneva E, Scheich H. 2015. Neuronal activity in primate auditory cortex during the performance of audiovisual tasks. European Journal of Neuroscience. 41(5):603-614. Available from: 10.1111/ejn.12841

     

    2014

    Brosch M. 2014. Associations and rewards in auditory cortex. Jaeger D, Jung R, editors. In Encyclopedia of computational Neuroscience. Berlin: Springer. Available from: 10.1007/978-1-4614-7320-6_105-4

    Lovell JM, Mylius J, Scheich H, Brosch M. 2014. Hearing in action; auditory properties of neurons in the red nucleus of alert primates. Frontiers in Neuroscience. (8 MAY). Available from: 10.3389/fnins.2014.00105

     

    2013

    Hoefer M, Tyll S, Kanowski M, Brosch M, Schoenfeld MA, Heinze HJ, Noesselt T. 2013. Tactile stimulation and hemispheric asymmetries modulate auditory perception and neural responses in primary auditory cortex. NeuroImage. 79:371-382. Available from: 10.1016/j.neuroimage.2013.04.119

    Selezneva E, Deike S, Knyazeva S, Scheich H, Brechmann A, Brosch M. 2013. Rhythm sensitivity in macaque monkeys. Frontiers in Systems Neuroscience. 7(SEP). Available from: 10.3389/fnsys.2013.00049

    Brosch M, Budinger E, Scheich H. 2013. Different Synchronization Rules in Primary and Nonprimary Auditory Cortex of Monkeys. Journal of Cognitive Neuroscience. 25(9):1517-1526. Available from: 10.1162/jocn_a_00413

    Budinger E, Brosch M, Scheich H, Mylius J. 2013. The subcortical auditory structures in the Mongolian gerbil: II. Frequency-related topography of the connections with cortical field AI. Journal of Comparative Neurology. 521(12):2772-2797. Available from: 10.1002/cne.23314

    Mallow J, Herrmann T, Kim KN, Stadler J, Mylius J, Brosch M, Bernarding J. 2013. Ultra-high field MRI for primate imaging using the travelling-wave concept. Magnetic Resonance Materials in Physics, Biology, and Medicine. 26(4):389-400. Available from: 10.1007/s10334-012-0358-z

    Mylius J, Brosch M, Scheich H, Budinger E. 2013. Subcortical auditory structures in the mongolian gerbil: I. Golgi architecture. Journal of Comparative Neurology. 521(6):1289-1321. Available from: 10.1002/cne.23232

     

    2012

    Lovell J, Brosch M, Budinger E, Goldschmidt J, Scheich H, Tschorn S, Wendt B, Zuschratter W. 2012. Scanning and Transmission Electron Microscope Examination of Cochlea Hair and Pillar Cells from the Ear of the Mongolian Gerbil (Meriones unguiculatus). Anatomy and Physiology. 2(3).

    Selezneva E, Gorkin A, Mylius J, Noesselt T, Scheich H, Brosch M. 2012. Reaction times reflect subjective auditory perception of tone sequences in macaque monkeys. Hearing Research. 294(1-2):133-142. Available from: 10.1016/j.heares.2012.08.014

    Scheich H, Brosch M. 2012. Task-releated activation of auditory cortex. In: Neural correlates of auditory cognition. In Neural correlates of auditory cognition. New York: Springer. pp. 45-81.

     

    2011

    Brosch M, Selezneva E, Scheich H. 2011. Representation of reward feedback in primate auditory cortex. Frontiers in Systems Neuroscience. (FEBRUARY 2011). Available from: 10.3389/fnsys.2011.00005

    Brechmann A, Brosch M, Budinger E, Heil P, König R, Ohl F, Scheich H. 2011. Auditory cortex - Current concepts in human and animal research. Hearing Research. 271(1-2):1-2. Available from: 10.1016/j.heares.2010.10.016

    Scheich H, Brechmann A, Brosch M, Budinger E, Ohl FW, Selezneva E, Stark H, Tischmeyer W, Wetzel W. 2011. Behavioral semantics of learning and crossmodal processing in auditory cortex: The semantic processor concept. Hearing Research. 271(1-2):3-15. Available from: 10.1016/j.heares.2010.10.006

    Brosch M, Selezneva E, Scheich H. 2011. Formation of associations in auditory cortex by slow changes of tonic firing. Hearing Research. 271(1-2):66-73. Available from: 10.1016/j.heares.2010.05.003

  • Teaching

    Teaching

    Members of our special lab are involved in the following courses of the OVGU:

    • Introduction to Programming with Matlab (annually since 2008)                                     
    • Systems Neuroscience (annually since 2009)
      • Introduction to Programming with Matlab Systems Neuroscience
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