LIN Staff

Prof. Dr. Eike Budinger

Head of Working Group

Combinatorial NeuroImaging

Leibniz Institute for Neurobiology
Brenneckestr. 6
39118 Magdeburg
Germany
Phone: +49 391 6263 95421
Email: Eike.Budinger@lin-magdeburg.de
ORCID: 0000-0003-2420-8159

  • Research interests

    Research interests

    biomedical sciences, neuroscience, functional anatomy, auditory system, multisensory integration, deep brain stimulation, hemispheric interactions, stress resilience, development, sensory deprivation, small-animal magnetic resonance imaging, anatomical and functional connectivity, brain clearing, light-sheet microscopy

    Link to website of group:

    https://www.lin-magdeburg.org/cni/functional-neuroanatomy

    Link to NeuroTree:

    https://neurotree.org/beta/tree.php?pid=67355

    Link to ORCID:

    https://orcid.org/0000-0003-2420-8159

    Links to some project websites:

    https://sfb1436.de/projects/mobilisation-of-neural-resources-for-temporal-attention-2/

    http://www.cbbs.eu/forschungsfoerderung/neuronetzwerke/nn-15

    https://www.abinep.ovgu.de/Module+1/Fellows/Rituparna+Bhattacharjee.html

    http://www.learning-resilience.de/index.php

  • Curriculum vitae

    Curriculum vitae

    1990-1995: Study of biology at the Humboldt University Berlin; major subjects: zoology, behavioral sciences, and microbiology

    1995: Diploma at the Department of Behavioral Physiology, Institute of Biology, Humboldt University Berlin. Thesis: “Electrophysiological investigations on the processing of spatial acoustic cues in the central nervous system of grasshoppers”. Mentor: Prof. Bernhard Ronacher

    1995-1999: Ph.D. student at the Leibniz Institute for Neurobiology Magdeburg (LIN), Center for Learning and Memory Research; Dept. Auditory Learning and Speech

    2000: Dissertation (Dr. rer. nat.) at the Otto-von-Guericke-University Magdeburg. Thesis: “Functional organization of the auditory cortex in Mongolian gerbils (Meriones unguiculatus). Anatomical areas, corticocortical connections and connections with anatomically characterized subcortical structures”. Mentor: Prof. Henning Scheich

    Since 1999: Scientific fellow (with varying positions) at the LIN, Depts. Auditory Learning and Speech and Systems Physiology of Learning

    2003-2014: Collaborating scientist at the Otto-von-Guericke-University Magdeburg, Clinic for Neurology

    2005-2017: Principal investigator of the project “Functional anatomy and plasticity of the auditory cortex” at the LIN

    2015: Habilitation (PD Dr. rer. nat. habil.) at the Otto-von-Guericke-University Magdeburg. Thesis: “Anatomy of auditory cortex connections suitable for the processing of multisensory information and for the consolidation of memory". Venia legendi in neurobiology and zoology

    Since 2017: Head of the group “Functional Neuroanatomy & Small-animal MRI” Laboratory

    2021: Title adjunct professor (apl. Prof. Dr. rer. nat. habil.) at the Otto-von-Guericke-University Magdeburg

    Further information:

    Link to website of group:

    https://www.lin-magdeburg.org/cni/functional-neuroanatomy

    Link to NeuroTree:

    https://neurotree.org/beta/tree.php?pid=67355

    Link to ORCID:

    https://orcid.org/0000-0003-2420-8159

    Links to some project websites:

    https://sfb1436.de/projects/mobilisation-of-neural-resources-for-temporal-attention-2/

    http://www.cbbs.eu/forschungsfoerderung/neuronetzwerke/nn-15

    https://www.abinep.ovgu.de/Module+1/Fellows/Rituparna+Bhattacharjee.html

    http://www.learning-resilience.de/index.php

  • Publications

    Publications

    Liu P, Doehler J, Henschke JU, Northall A, Serian A, Loaiza-Carvajal LC, Budinger E, Schwarzkopf DS, Speck O, Pakan JMP, et al. 2024. Cortical sensory aging is layer-specific. bioRxiv. (bioRxiv). https://doi.org/10.1101/2023.12.01.567841

    Kalantari A, Shahbazi M, Schneider M, Raikes AC, Frazão VV, Bhattrai A, Carnevale L, Diao Y, Franx BAA, Gammaraccio F, et al. 2024. Automated quality control of small animal MR neuroimaging data. Imaging Neuroscience. 2:1-23. https://doi.org/10.1162/imag_a_00317

    Eichner C, Paquette M, Müller-Axt C, Bock C, Budinger E, Gräßle T, Jäger C, Kirilina E, Lipp I, Morawski M, et al. 2024. Detailed mapping of the complex fiber structure and white matter pathways of the chimpanzee brain. Nature Methods. 21(6):1122-1130. https://doi.org/10.1038/s41592-024-02270-1

    Wendlandt TA, Wenk P, Henschke JU, Michalek A, Noesselt T, Pakan JMP, Budinger E. 2024. Neural networks representing temporal expectation in mice. bioRxiv. (bioRxiv). https://doi.org/10.1101/2024.04.25.589683

    Oelschlegel AM, Bhattacharjee R, Wenk P, Harit K, Rothkötter H-J, Koch SP, Boehm-Sturm P, Matuschewski K, Budinger E, Schlüter D, et al. 2024. Beyond the microcirculation: sequestration of infected red blood cells and reduced flow in large draining veins in experimental cerebral malaria. Nature Communications. 15(1):Article 2396. https://doi.org/10.1038/s41467-024-46617-w

    Gu M, Li X, Liang S, Zhu J, Sun P, He Y, Yu H, Li R, Zhou Z, Lyu J, et al. 2023. Rabies virus-based labeling of layer 6 corticothalamic neurons for two-photon imaging in vivo. iScience. 26(5):Article 106625. https://doi.org/10.1016/j.isci.2023.106625

    Grandjean J, Desrosiers-Gregoire G, Anckaerts C, Angeles-Valdez D, Ayad F, Barrière DA, Blockx I, Bortel A, Broadwater M, Cardoso BM, et al. 2023. A consensus protocol for functional connectivity analysis in the rat brain. Nature Neuroscience. 26(4):673-681. https://doi.org/10.1038/s41593-023-01286-8

    Saldeitis K, Jeschke M, Michalek A, Henschke JU, Wetzel W, Ohl FW, Budinger E. 2022. Selective interruption of auditory interhemispheric crosstalk impairs discrimination learning of frequency-modulated tone direction but not gap detection and discrimination. Journal of Neuroscience. 42(10):2025-2038. https://doi.org/10.1523/JNEUROSCI.0216-21.2022

    Saldeitis K, Jeschke M, Budinger E, Ohl FW, Happel MFK. 2021. Laser-Induced Apoptosis of Corticothalamic Neurons in Layer VI of Auditory Cortex Impact on Cortical Frequency Processing. Frontiers in neural circuits. 15:Article 659280. https://doi.org/10.3389/fncir.2021.659280

    El-Tabbal M, Niekisch H, Henschke JU, Budinger E, Frischknecht R, Deliano M, Happel MFK. 2021. The extracellular matrix regulates cortical layer dynamics and cross-columnar frequency integration in the auditory cortex. Communications biology. 4(1):Article 322. https://doi.org/10.1038/s42003-021-01837-4

    Heimrath K, Brechmann A, Blobel-Lüer R, Stadler J, Budinger E, Zaehle T. 2020. Transcranial direct current stimulation (tDCS) over the auditory cortex modulates GABA and glutamate: a 7 T MR-spectroscopy study. Scientific Reports. 10(1):Article 20111. https://doi.org/10.1038/s41598-020-77111-0

    Budinger E. 2020. 2.32 - Primary Auditory Cortex and the Thalamo-Cortico-Thalamic Circuitry I. Anatomy. In The Senses: A Comprehensive Reference: Volume 1-7, Second Edition. Elsevier. pp. 623-656. https://doi.org/10.1016/B978-0-12-805408-6.00022-1

    Saldeitis K, Richter K, Fischer K-D, Ohl FW, Mateos JM, Budinger E. 2019. Ultrastructure of giant thalamic terminals in the auditory cortex. European Journal of Neuroscience. 50(9):3445-3453. https://doi.org/10.1111/ejn.14509

    Schicknick H, Henschke JU, Budinger E, Ohl FW, Gundelfinger ED, Tischmeyer W. 2019. β-adrenergic modulation of discrimination learning and memory in the auditory cortex. European Journal of Neuroscience. 50(7):3141-3163. https://doi.org/10.1111/ejn.14480

    Macharadze T, Budinger E, Brosch M, Scheich H, Ohl FW, Henschke JU. 2019. Early Sensory Loss Alters the Dendritic Branching and Spine Density of Supragranular Pyramidal Neurons in Rodent Primary Sensory Cortices. Frontiers in neural circuits. 13:Article 61. https://doi.org/10.3389/fncir.2019.00061

    Lützkendorf R, Heidemann RM, Feiweier T, Luchtmann M, Baecke S, Kaufmann J, Stadler J, Budinger E, Bernarding J. 2018. Mapping fine-scale anatomy of gray matter, white matter, and trigeminal-root region applying spherical deconvolution to high-resolution 7-T diffusion MRI. Magnetic Resonance Materials in Physics, Biology, and Medicine. 31(6):701-713. https://doi.org/10.1007/s10334-018-0705-9

    Selezneva E, Gorkin A, Budinger E, Brosch M. 2018. Neuronal correlates of auditory streaming in the auditory cortex of behaving monkeys. European Journal of Neuroscience. 48(10):3234-3245. https://doi.org/10.1111/ejn.14098

    Annamneedi A, Caliskan G, Müller S, Montag D, Budinger E, Angenstein F, Fejtova A, Tischmeyer W, Gundelfinger ED, Stork O. 2018. Ablation of the presynaptic organizer Bassoon in excitatory neurons retards dentate gyrus maturation and enhances learning performance. Brain Structure and Function. 223(7):3423-3445. https://doi.org/10.1007/s00429-018-1692-3

    Henschke JU, Oelschlegel AM, Angenstein F, Ohl FW, Goldschmidt J, Kanold PO, Budinger E. 2018. Early sensory experience influences the development of multisensory thalamocortical and intracortical connections of primary sensory cortices. Brain Structure and Function. 223(3):1165-1190. https://doi.org/10.1007/s00429-017-1549-1

    Henschke JU, Ohl FW, Budinger E. 2018. Crossmodal connections of primary sensory cortices largely vanish during normal aging. Frontiers in Aging Neuroscience. 10(MAR):Article 52. https://doi.org/10.3389/fnagi.2018.00052

    Budinger E, Kanold P. 2018. Auditory cortical circuits. Oliver DL, Cant N, Fay RR, Popper AN, editors. In The Mammalian Auditory Pathways: Synaptic Organization and Microcircuits. New York: Springer. pp. 199 - 233. (Springer Handbook of Auditory Research). https://doi.org/10.1007/978-3-319-71798-2_8

    Radtke-Schuller S, Schuller G, Angenstein F, Grosser OS, Goldschmidt J, Budinger E. 2016. Brain atlas of the Mongolian gerbil (Meriones unguiculatus) in CT/MRI-aided stereotaxic coordinates. Brain Structure and Function. 221 Suppl 1(Suppl. 1):1-272. https://doi.org/10.1007/s00429-016-1259-0

    Spilker C, Nullmeier S, Grochowska KM, Schumacher A, Butnaru I, Macharadze T, Gomes GM, YuanXiang P, Bayraktar G, Rodenstein C, et al. 2016. A Jacob/Nsmf Gene Knockout Results in Hippocampal Dysplasia and Impaired BDNF Signaling in Dendritogenesis. PLoS Genetics. 12(3):Article e1005907. https://doi.org/10.1371/journal.pgen.1005907

    Budinger E, Brechmann A, Brosch M, Heil P, König R, Ohl FW, Scheich H. 2015. Auditory cortex 2014 - towards a synthesis of human and animal research. European Journal of Neuroscience. 41(5):515-517. https://doi.org/10.1111/ejn.12832

    Henschke JU, Noesselt T, Scheich H, Budinger E. 2015. Possible anatomical pathways for short-latency multisensory integration processes in primary sensory cortices. Brain Structure and Function. 220(2):955-977. https://doi.org/10.1007/s00429-013-0694-4

    Saldeitis K, Happel MFK, Ohl FW, Scheich H, Budinger E. 2014. Anatomy of the auditory thalamocortical system in the mongolian gerbil: Nuclear origins and cortical field-, layer-, and frequency-specificities. Journal of Comparative Neurology. 522(10):2397-2430. https://doi.org/10.1002/cne.23540

    Hunger M, Budinger E, Zhong K, Angenstein F. 2014. Visualization of acute focal lesions in rats with experimental autoimmune encephalomyelitis by magnetic nanoparticles, comparing different MRI sequences including phase imaging. Journal of Magnetic Resonance Imaging. 39(5):1126-1135. https://doi.org/10.1002/jmri.24280

    Rehberg K, Kliche S, Madencioglu DA, Thiere M, Müller B, Manuel Meineke B, Freund C, Budinger E, Stork O. 2014. The serine/threonine kinase Ndr2 controls integrin trafficking and integrin-dependent neurite growth. Journal of Neuroscience. 34(15):5342-5354. https://doi.org/10.1523/JNEUROSCI.2728-13.2014

    Lison H, Happel MFK, Schneider F, Baldauf K, Kerbstat S, Seelbinder B, Schneeberg J, Zappe M, Goldschmidt J, Budinger E, et al. 2014. Disrupted cross-laminar cortical processing in β amyloid pathology precedes cell death. Neurobiology of Disease. 63:62-73. https://doi.org/10.1016/j.nbd.2013.11.014

    Budinger E, ed. 2014. Towards a Synthesis of Human and Animal Research: Proceedings of the 5th International Conference on Auditory Cortex. Magdeburg, Germany: Docupoint Verlag. 158 p.

    Brosch M, Budinger E, Scheich H. 2013. Different Synchronization Rules in Primary and Nonprimary Auditory Cortex of Monkeys. Journal of Cognitive Neuroscience. 25(9):1517-1526. https://doi.org/10.1162/jocn_a_00413

    Budinger E, Brosch M, Scheich H, Mylius J. 2013. The subcortical auditory structures in the Mongolian gerbil: II. Frequency-related topography of the connections with cortical field AI. Journal of Comparative Neurology. 521(12):2772-2797. https://doi.org/10.1002/cne.23314

    Mylius J, Brosch M, Scheich H, Budinger E. 2013. Subcortical auditory structures in the mongolian gerbil: I. Golgi architecture. Journal of Comparative Neurology. 521(6):1289-1321. https://doi.org/10.1002/cne.23232

    Bonath B, Tyll S, Budinger E, Krauel K, Hopf JM, Noesselt T. 2013. Task-demands and audio-visual stimulus configurations modulate neural activity in the human thalamus. NeuroImage. 66:110-118. https://doi.org/10.1016/j.neuroimage.2012.10.018

    Riedel A, Stöber F, Richter K, Fischer KD, Miettinen R, Budinger E. 2013. VGLUT3-immunoreactive afferents of the lateral septum: Ultrastructural evidence for a modulatory role of glutamate. Brain Structure and Function. 218(1):295-301. https://doi.org/10.1007/s00429-012-0395-4

    MacHaradze T, Pielot R, Wanger T, Scheich H, Gundelfinger ED, Budinger E, Goldschmidt J, Kreutz MR. 2012. Altered neuronal activity patterns in the visual cortex of the adult rat after partial optic nerve crush-a single-cell resolution metabolic mapping study. Cerebral Cortex. 22(8):1824-1833. https://doi.org/10.1093/cercor/bhr256

    Lovell J, Brosch M, Budinger E, Goldschmidt J, Scheich H, Tschorn S, Wendt B, Zuschratter W. 2012. Scanning and Transmission Electron Microscope Examination of Cochlea Hair and Pillar Cells from the Ear of the Mongolian Gerbil (Meriones unguiculatus). Anatomy and Physiology. 2(3).

    Haroon F, Händel U, Angenstein F, Goldschmidt J, Kreutzmann P, Lison H, Fischer KD, Scheich H, Wetzel W, Schlüter D, et al. 2012. Toxoplasma gondii actively inhibits neuronal function in chronically infected mice. PLoS ONE. 7(4):e35516. https://doi.org/10.1371/journal.pone.0035516

    Budinger E, Heil P. 2012. Anatomy of the auditory cortex. In Listening to Speech: An Auditory Perspective. Taylor & Francis Group. pp. 91-113. https://doi.org/10.4324/9780203933107

    Tyll S, Budinger E, Noesselt T. 2011. Thalamic influences on multisensory integration. Communicative and Integrative Biology. 4(4):378-381. https://doi.org/10.4161/cib.15222

    Brechmann A, Brosch M, Budinger E, Heil P, König R, Ohl F, Scheich H. 2011. Auditory cortex - Current concepts in human and animal research. Hearing Research. 271(1-2):1-2. https://doi.org/10.1016/j.heares.2010.10.016

    Scheich H, Brechmann A, Brosch M, Budinger E, Ohl FW, Selezneva E, Stark H, Tischmeyer W, Wetzel W. 2011. Behavioral semantics of learning and crossmodal processing in auditory cortex: The semantic processor concept. Hearing Research. 271(1-2):3-15. https://doi.org/10.1016/j.heares.2010.10.006

    Noesselt T, Tyll S, Boehler CN, Budinger E, Heinze HJ, Driver J. 2010. Sound-induced enhancement of low-intensity vision: Multisensory influences on human sensory-specific cortices and thalamic bodies relate to perceptual enhancement of visual detection sensitivity. Journal of Neuroscience. 30(41):13609-13623. https://doi.org/10.1523/JNEUROSCI.4524-09.2010

    Budinger E, Scheich H. 2009. Anatomical connections suitable for the direct processing of neuronal information of different modalities via the rodent primary auditory cortex. Hearing Research. 258(1-2):16-27. https://doi.org/10.1016/j.heares.2009.04.021

    Schicknick H, Schott BH, Budinger E, Smalla KH, Riedel A, Seidenbecher CI, Scheich H, Gundelfinger ED, Tischmeyer W. 2008. Dopaminergic modulation of auditory cortex-dependent memory consolidation through mTOR. Cerebral Cortex. 18(11):2646-2658. https://doi.org/10.1093/cercor/bhn026

    Jeschke M, Lenz D, Budinger E, Herrmann CS, Ohl FW. 2008. Gamma oscillations in gerbil auditory cortex during a target-discrimination task reflect matches with short-term memory. Brain Research. 1220:70-80. https://doi.org/10.1016/j.brainres.2007.10.047

    Budinger E, Laszcz A, Lison H, Scheich H, Ohl FW. 2008. Non-sensory cortical and subcortical connections of the primary auditory cortex in Mongolian gerbils: Bottom-up and top-down processing of neuronal information via field AI. Brain Research. 1220:2-32. https://doi.org/10.1016/j.brainres.2007.07.084

    Kurt S, Deutscher A, Crook JM, Ohl FW, Budinger E, Moeller CK, Scheich H, Schulze H. 2008. Auditory cortical contrast enhancing by global winner-take-all inhibitory interactions. PLoS ONE. 3(3):e1735. https://doi.org/10.1371/journal.pone.0001735

    Budinger E, Klump GM, ed. 2008. Proceedings of the International Workshop "The Mongolian gerbil as a model for auditory research". Magdeburg, Germany: Docupoint Verlag.

    Scheich H, Brechmann A, Brosch M, Budinger E, Ohl FW. 2007. The cognitive auditory cortex: Task-specificity of stimulus representations. Hearing Research. 229(1-2):213-224. https://doi.org/10.1016/j.heares.2007.01.025

    Budinger E, Heil P, Hess A, Scheich H. 2006. Multisensory processing via early cortical stages: Connections of the primary auditory cortical field with other sensory systems. Neuroscience. 143(4):1065-1083. https://doi.org/10.1016/j.neuroscience.2006.08.035

    Bernstein HG, Lendeckel U, Bertram I, Bukowska A, Kanakis D, Dobrowolny H, Stauch R, Krell D, Mawrin C, Budinger E, et al. 2006. Localization of neuregulin-1α (heregulin-α) and one of its receptors, ErbB-4 tyrosine kinase, in developing and adult human brain. Brain Research Bulletin. 69(5):546-559. https://doi.org/10.1016/j.brainresbull.2006.02.017

    Budinger E. 2005. Introduction: Auditory cortical fields and their functions. Heil P, Scheich H, Budinger E, König R, editors. In The Auditory Cortex: A Synthesis of Human and Animal Research. 1st ed. New York: Taylor & Francis Group. pp. 3-6. https://doi.org/10.4324/9781410613066

    König R, Heil P, Budinger E, Scheich H 2005. The auditory cortex: Towards a synthesis of human and animal research. Lawrence Earlbaum, New Jersey, USA. 493 p. https://doi.org/10.4324/9781410613066

    Budinger E, Heil P. 2005. Anatomy of the auditory cortex. In Listening to Speech: An Auditory Perspective. Lawrence Earlbaum, New Jersey, USA. pp. 91-113.

    Budinger E, Gaschler-Markefski B 2003. Proceedings of the International Conference on Auditory Cortex – Towards a Synthesis of Human and Animal Research. Aachen, Germany: Shaker Verlag, Aachen, Germany.

    Brosch M, Budinger E, Scheich H. 2002. Stimulus-related gamma oscillations in primate auditory cortex. Journal of Neurophysiology. 87(6):2715-2725. https://doi.org/10.1152/jn.2002.87.6.2715

    Krahe R, Budinger E, Ronacher B. 2002. Coding of a sexually dimorphic song feature by auditory interneurons of grasshoppers: the role of leading inhibition. Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology. 187(12):977-985. https://doi.org/10.1007/s00359-001-0268-4

    Budinger E, Heil P, Scheich H. 2000. Functional organization of auditory cortex in the Mongolian gerbil (Meriones unguiculatus). III. Anatomical subdivisions and corticocortical connections. European Journal of Neuroscience. 12(7):2425-2451. https://doi.org/10.1046/j.1460-9568.2000.00142.x

    Budinger E, Heil P, Scheich H. 2000. Functional organization of auditory cortex in the Mongolian gerbil (Meriones unguiculatus). IV. Connections with anatomically characterized subcortical structures. European Journal of Neuroscience. 12(7):2452-2474. https://doi.org/10.1046/j.1460-9568.2000.00143.x
  • Third party funds

    Third party funds

    2022 - 2025 (WGL)
    Learning Resilience: Supporting neuronal network state transitions to foster stress resilience, Arbeitspaket 2 (self-balancing of cortical network states in stress recilience) und 3 (Brain-wide network state changes in cognitive flexibility behavioral fMRI)

    2020 - 2024 (DFG)
    SFB 1436 TP B06: Mobilisierung neuronaler Ressourcen für zeitliche Aufmerksamkeit
    https://sfb1436.de/projects/mobilisation-of-neural-resources-for-temporal-attention-2/

    2020 - 2022 (LSA)
    "Non-Invasive Deep Brain Stimulation for Motor Disorder (NeeMo)"
    http://www.cbbs.eu/forschungsfoerderung/neuronetzwerke/nn-15

    2016 - 2018 (LSA)
    Ansiedlung eines 9,4 Tesla-Kleintier-MRT (Beschaffung, Einbau und Inbetriebnahme)

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