Functional Neuroanatomy & Small-Animal-MRI
One of the main questions in neuroscience is the relationship between the structure and function of the brain.
The project group "Functional anatomy and small-animal-MRI" approaches this issue using state-of-the-art anatomical (immunohistochemistry, neuronal tract tracing, brain clearing) methods and related microscopical techniques (brightfield, epifluorescence, confocal, electron, lightsheet microscopy) but most importantly non-invasive brain imaging (9.4 Tesla small-animal magnetic resonance tomography).
We combine the anatomical and imaging methods with various behavioral approaches and stimulation paradigms (sensory, electrical, optogenetic) in various animal models (mouse, rat, gerbil, transgenic, disease models) in order to gain deep insights into the function of the brain under various conditions (healthy/diseased, young/old, trained/naive etc.).
- Head
Head
Eike Budinger studied biology at the Humboldt-University Berlin with a focus on zoology, behavioral biology and microbiology. Subsequently he earned his doctorate at the Leibniz Institute for Neurobiology (LIN) Magdeburg in the department "Acoustics, Learning and Speech" under Prof. Dr. Henning Scheich. The topic of his dissertation was entitled "The functional organization of the auditory cortex of the Mongolian gerbil (Meriones unguiculatus). Anatomical areas, corticocortical connections and connections with anatomically characterized subcortical structures".
Eike Budinger was then research associate with various positions at LIN in the departments "Acoustics, Learning and Speech" and "Systems Physiology of Learning" as well as at the Medical Faculty of the Otto-von-Guericke-University (OvGU) Magdeburg. Since 2005 he heads the project group "Functional Neuroanatomy" and since 2017 the 9.4 Tesla “Small Animal MRI Lab” at the LIN.
In 2015, Eike Budinger habilitated at the Faculty of Natural Sciences of the OvGU with the thesis "Anatomy of the neuronal connections of the auditory cortex for the processing of multisensory information and for memory formation". In 2021, he became extracurricular professor at the OvGU.
- Members
Members
Head Prof. Dr. Eike Budinger +49-391-6263-95421 eike.budinger@lin-magdeburg.de PhD students Fahmida Akter +49-391-6263-95431 fahmida.akter@lin-magdeburg.de Lisa-Marie Goncalves +49-391-6263-93471 Lisa-Marie.Goncalves@lin-magdeburg.de Annika Michalek +49-391-6263-92171 annika.michalek@lin-magdeburg.de Technical staff members Anja Gürke +49-391-6263-95461 anja.guerke@lin-magdeburg.de Janet Stallmann +49-391-6263-95461 janet.stallmann@lin-magdeburg.de Application specialist Patricia Wenk +49-391-6263-95431 patricia.wenk@lin-magdeburg.de Guests Rituparna Bhattacharjee (ABINEP) +49-391-6263-93471 rituparna.bhattacharjee@med.ovgu.de - Projects
Projects
Current projects:
- Functional organization of the auditory pathway
- Hemispheric crosstalk during auditory learning
- Investigation of neuroinflammatory processes
- Phenotyping of transgenic mouse models
- Brain atlases
- Transcranial direct current stimulation (TDCS) for deep brain stimulation
- Neurotranmitter balance in the brain (magnetic resonance spectroscopy)
- Brain-wide network states transitions associated with learning and stress resilience
- Influence of physical activity on brain structure and function
- Investigation of multisensory integration processes for the mobilisation of neural resources
- Current Third Party Funds
Current Third Party Funds
2022-2024
Leibniz Cooperative Excellence: Learning Resilience: Supporting neuronal network state transitions to foster stress resilience
Project 3 „Brain-wide network state transitions associated with cognitive flexibility in the framework of stress resilience“
https://www.leibniz-gemeinschaft.de/en/research/leibniz-competition/funded-projects
2021-2025
DFG CRC 1436 - Neural Resources of Cognition:
Project B06 “Mobilisation of neural resources for temporal attention” (Budinger, Noesselt, Pakan)
http://www.iknd.ovgu.de/SFB+1436.html2020-2023
CBBS NeuroNetwork
Non-Invasive Deep Brain Stimulation for Motor Disorders (NeeMo)
http://www.cbbs.eu/en/research-funding/neuronetworkso
2018-2023
LIN Special Project
Crosstalk between hemispheres during auditory learning: disturbance and compensation
2016-2018
European Regional Development Fund (ERDF) and State of Saxony Anhalt:
Settlement of a 9.4 T small animal magnetic resonance tomograph
https://europa.sachsen-anhalt.de/esi-fonds-in-sachsen-anhalt/esi-fonds-in-sachsen-anhalt
2016-2022
ABINEP - Analysis, Imaging, and Modelling of Neuronal and Inflammatory Processes:
Module 1: Neuroinflammation: Inflammatory processes in neurodegeneration; Project 2: Development of new techniques for visualization of neuroinflammatory processes during infections and autoimmunity diseases of the brain
http://www.abinep.ovgu.de/ - Publications
Publications
2021
El-Tabbal M, Niekisch H, Henschke JU, Budinger E, Frischknecht R, Deliano M, Happel MFK. The extracellular matrix regulates cortical layer dynamics and cross-columnar frequency integration in the auditory cortex. Communications Biology 4(1):322. doi: 10.1038/s42003-021-01837-4. https://www.nature.com/articles/s42003-021-01837-4
Saldeitis K, Jeschke M, Budinger E, Ohl FW, Happel MFK. Laser-induced apoptosis of corticothalamic neurons in layer VI of auditory cortex impact on cortical frequency processing Frontiers in Neural Circuits. doi: 10.3389/fncir.2021.659280
2020
Heimrath K, Brechmann A, Blobel-Lüer R, Stadler J, Budinger E, Zaehle T. Transcranial direct current stimulation (tDCS) over the auditory cortex modulates GABA and glutamate: a 7 T MR-spectroscopy study. Scientific Reports 10(1):20111. 10.1038/s41598-020-77111-0
2019
Macharadze T, Budinger E, Brosch M, Scheich H, Ohl FW, Henschke JU. 2019. Early sensory loss alters the dendritic branching and spine density of supragranular pyramidal neurons in rodent primary sensory cortices. Frontiers in Neural Circuits 13:61.https://doi.org/10.3389/fncir.2019.00061
Schicknick H, Henschke JU, Budinger E, Ohl FW, Gundelfinger ED, Tischmeyer W. 2019. β-adrenergic modulation of discrimination learning and memory in the auditory cortex. European Journal of Neuroscience 50(7):3141-3163.https://doi.org/10.1111/ejn.14480
Saldeitis K, Richter K, Fischer KD, Ohl FW, Mateos JM, Budinger E. 2019. Ultrastructure of giant thalamic terminals in the auditory cortex. European Journal of Neuroscience 50(9):3445-3453. https://doi.org/10.1111/ejn.14509
2018
Budinger E, Kanold P. 2018. Auditory cortical circuits. Oliver DL, Cant N, Fay RR, Popper AN, Hrsg. in The Mammalian Auditory Pathways: Synaptic Organization and Microcircuits. New York: Springer. S. 199 - 233. (Springer Handbook of Auditory Research). https://doi.org/10.1007/978-3-319-71798-2_8
Henschke JU, Ohl FW, Budinger E. 2018. Crossmodal connections of primary sensory cortices largely vanish during normal aging. Frontiers in Aging Neuroscience. 10(MAR). https://doi.org/10.3389/fnagi.2018.00052
Henschke JU, Oelschlegel AM, Angenstein F, Ohl FW, Goldschmidt J, Kanold PO, Budinger E. 2018. Early sensory experience influences the development of multisensory thalamocortical and intracortical connections of primary sensory cortices. Brain Structure and Function. 223(3):1165-1190. https://doi.org/10.1007/s00429-017-1549-1
Annamneedi A, Caliskan G, Müller S, Montag D, Budinger E, Angenstein F, Fejtova A, Tischmeyer W, Gundelfinger ED, Stork O. 2018. Ablation of the presynaptic organizer Bassoon in excitatory neurons retards dentate gyrus maturation and enhances learning performance. Brain Structure and Function. 223(7):3423-3445. https://doi.org/10.1007/s00429-018-1692-3
Selezneva E, Gorkin A, Budinger E, Brosch M. 2018. Neuronal correlates of auditory streaming in the auditory cortex of behaving monkeys. European Journal of Neuroscience. 48(10):3234-3245. https://doi.org/10.1111/ejn.14098
Lützkendorf R, Heidemann RM, Feiweier T, Luchtmann M, Baecke S, Kaufmann J, Stadler J, Budinger E, Bernarding J. 2018. Mapping fine-scale anatomy of gray matter, white matter, and trigeminal-root region applying spherical deconvolution to high-resolution 7-T diffusion MRI. Magnetic Resonance Materials in Physics, Biology and Medicine. 31(6):701-713. https://doi.org/10.1007/s10334-018-0705-9
2016
Spilker C, Nullmeier S, Grochowska KM, Schumacher A, Butnaru I, Macharadze T, Gomes GM, YuanXiang P, Bayraktar G, Rodenstein C, Geiseler C, Kolodziej A, Lopez-Rojas J, Montag D, Angenstein F, Bär J, D’Hanis W, Roskoden T, Mikhaylova M, Budinger E, Ohl FW, Stork O, Zenclussen AC, Karpova A, Schwegler H, Kreutz MR. 2016. A Jacob/Nsmf Gene Knockout Results in Hippocampal Dysplasia and Impaired BDNF Signaling in Dendritogenesis. PLoS Genetics. 12(3). https://doi.org/10.1371/journal.pgen.1005907
Radtke-Schuller S, Schuller G, Angenstein F, Grosser OS, Goldschmidt J, Budinger E. 2016. Brain atlas of the Mongolian gerbil (Meriones unguiculatus) in CT/MRI-aided stereotaxic coordinates. Brain Structure and Function. 221 Suppl 1(Suppl. 1):1-272. https://doi.org/10.1007/s00429-016-1259-0
2015
Henschke JU, Noesselt T, Scheich H, Budinger E. 2015. Possible anatomical pathways for short-latency multisensory integration processes in primary sensory cortices. Brain Structure and Function. 220(2):955-977. https://doi.org/10.1007/s00429-013-0694-4
Budinger E, Brechmann A, Brosch M, Heil P, König R, Ohl FW, Scheich H. 2015. Auditory cortex 2014 - towards a synthesis of human and animal research. European Journal of Neuroscience. 41(5):515-517. https://doi.org/10.1111/ejn.12832
2014
Budinger E 2014. Proceedings of the 5th International Conference on Auditory Cortex – Towards a Synthesis of Human and Animal Research. Magdeburg, Germany: Docupoint Verlag, Magdeburg, Germany.
Lison H, Happel MFK, Schneider F, Baldauf K, Kerbstat S, Seelbinder B, Schneeberg J, Zappe M, Goldschmidt J, Budinger E, Schröder UH, Ohl FW, Schilling S, Demuth HU, Scheich H, Reymann KG, Rönicke R. 2014. Disrupted cross-laminar cortical processing in β amyloid pathology precedes cell death. Neurobiology of Disease. 63:62-73. https://doi.org/10.1016/j.nbd.2013.11.014
Rehberg K, Kliche S, Madencioglu DA, Thiere M, Müller B, Manuel Meineke B, Freund C, Budinger E, Stork O. 2014. The serine/threonine kinase Ndr2 controls integrin trafficking and integrin-dependent neurite growth. Journal of Neuroscience. 34(15):5342-5354. https://doi.org/10.1523/JNEUROSCI.2728-13.2014
Hunger M, Budinger E, Zhong K, Angenstein F. 2014. Visualization of acute focal lesions in rats with experimental autoimmune encephalomyelitis by magnetic nanoparticles, comparing different MRI sequences including phase imaging. Journal of Magnetic Resonance Imaging. 39(5):1126-1135. https://doi.org/10.1002/jmri.24280
Saldeitis K, Happel MFK, Ohl FW, Scheich H, Budinger E. 2014. Anatomy of the auditory thalamocortical system in the mongolian gerbil: Nuclear origins and cortical field-, layer-, and frequency-specificities. Journal of Comparative Neurology. 522(10):2397-2430. https://doi.org/10.1002/cne.23540
2013
Riedel A, Stöber F, Richter K, Fischer KD, Miettinen R, Budinger E. 2013. VGLUT3-immunoreactive afferents of the lateral septum: Ultrastructural evidence for a modulatory role of glutamate. Brain Structure and Function. 218(1):295-301. https://doi.org/10.1007/s00429-012-0395-4
Bonath B, Tyll S, Budinger E, Krauel K, Hopf JM, Noesselt T. 2013. Task-demands and audio-visual stimulus configurations modulate neural activity in the human thalamus. NeuroImage. 66:110-118. https://doi.org/10.1016/j.neuroimage.2012.10.018
Mylius J, Brosch M, Scheich H, Budinger E. 2013. Subcortical auditory structures in the mongolian gerbil: I. Golgi architecture. Journal of Comparative Neurology. 521(6):1289-1321. https://doi.org/10.1002/cne.23232
Budinger E, Brosch M, Scheich H, Mylius J. 2013. The subcortical auditory structures in the Mongolian gerbil: II. Frequency-related topography of the connections with cortical field AI. Journal of Comparative Neurology. 521(12):2772-2797. https://doi.org/10.1002/cne.23314
Brosch M, Budinger E, Scheich H. 2013. Different Synchronization Rules in Primary and Nonprimary Auditory Cortex of Monkeys. Journal of Cognitive Neuroscience. 25(9):1517-1526. https://doi.org/10.1162/jocn_a_00413
2012
Budinger E, Heil P. 2012. Anatomy of the auditory cortex. in Listening to Speech: An Auditory Perspective. Taylor & Francis Group. S. 91-113. https://doi.org/10.4324/9780203933107
Haroon F, Händel U, Angenstein F, Goldschmidt J, Kreutzmann P, Lison H, Fischer KD, Scheich H, Wetzel W, Schlüter D, Budinger E. 2012. Toxoplasma gondii actively inhibits neuronal function in chronically infected mice. PLoS ONE. 7(4):e35516. https://doi.org/10.1371/journal.pone.0035516
Lovell J, Brosch M, Budinger E, Goldschmidt J, Scheich H, Tschorn S, Wendt B, Zuschratter W. 2012. Scanning and Transmission Electron Microscope Examination of Cochlea Hair and Pillar Cells from the Ear of the Mongolian Gerbil (Meriones unguiculatus). Anatomy and Physiology. 2(3).
MacHaradze T, Pielot R, Wanger T, Scheich H, Gundelfinger ED, Budinger E, Goldschmidt J, Kreutz MR. 2012. Altered neuronal activity patterns in the visual cortex of the adult rat after partial optic nerve crush-a single-cell resolution metabolic mapping study. Cerebral Cortex. 22(8):1824-1833.https://doi.org/10.1093/cercor/bhr256
2011
Brechmann A, Brosch M, Budinger E, Heil P, König R, Ohl F, Scheich H. 2011. Auditory cortex - Current concepts in human and animal research. Hearing Research. 271(1-2):1-2. https://doi.org/10.1016/j.heares.2010.10.016
Scheich H, Brechmann A, Brosch M, Budinger E, Ohl FW, Selezneva E, Stark H, Tischmeyer W, Wetzel W. 2011. Behavioral semantics of learning and crossmodal processing in auditory cortex: The semantic processor concept. Hearing Research. 271(1-2):3-15. https://doi.org/10.1016/j.heares.2010.10.006
Tyll S, Budinger E, Noesselt T. 2011. Thalamic influences on multisensory integration. Communicative and Integrative Biology. 4(4):378-381.https://doi.org/10.4161/cib.15222
2010
Noesselt T, Tyll S, Boehler CN, Budinger E, Heinze HJ, Driver J. 2010. Sound-induced enhancement of low-intensity vision: Multisensory influences on human sensory-specific cortices and thalamic bodies relate to perceptual enhancement of visual detection sensitivity. Journal of Neuroscience. 30(41):13609-13623. https://doi.org/10.1523/JNEUROSCI.4524-09.2010
- Teaching
Teaching
We are involved in the training of students and interns. This includes lectures (e.g. in neuroanatomy) at the OvGU Magdeburg and courses at LIN.
- More about us
More about us
Volksstimme from September 27, 2018