Department Functional Architecture of Memory

The temporal lobe is an important brain structure in the memory process. If these brain regions are damaged, serious memory disorders occur - often in older people and in patients with memory loss.

The focus of our research is on identifying the specific contribution of the different areas of the medial temporal lobe to memory performance in terms of time and space. In addition, the memory process in relation to familiarity/recollection and encoding/retrieval are the focus of our research interest, as is the characterization of changes in brain areas within the aging process.

 

Selected publications

  • Head

    Head

    Magdalena Sauvage

    After a PhD on the effect of chronic stress on memory function at the MPI in Munich, Germany (Holsboer/ Steckler lab), Magdalena Sauvage did postdocs at MIT (Graybiel lab) and Boston University (Eichenbaum lab), followed by a Research Assistant Professorship in Eichenbaum lab in Boston USA and an Associate Professorship at the RUB (W2; Bochum, Germany).

    Since 2016 Professor Sauvage has headed the Functional Architecture of Memory Department and is one of the co-directors of the LIN.

    The originality of our approach is an innovative experimental approach combining a number of different techniques. We combine behavioral testing with other methods such as lesions, high-resolution neuroanatomical imaging and optogenetic techniques, as well as mutagenesis and in-vivo electrophysiology.

  • Members

    Members

    Head  
    Prof. Dr. Magdalena Sauvage+49-391-6263-94011magdalena.sauvage@lin-magdeburg.de
    Secretary  
    Jessica Levin+49-391-6263-94531jessica.levin@lin-magdeburg.de
    Group leader  
    Dr. Motoharu Yoshida+49-391-6263-94011motoharu.yoshida@lin-magdeburg.de
    Postdoc  
    Dr. Shih-Pi Ku+49-391-6263-94501shih-pi.ku@lin-magdeburg.de
    Dr. Erika Atucha Trevino+49-391-6263-94501erika.trevino@lin-magdeburg.de
    PhD students  
    Yacine Brahimi+49-391-6263-94491yacine.brahimi@lin-magdeburg.de
    Simone Calabrese       +49-391-6263-94501 simone.calabrese@lin-magdeburg.de
    Liv Mahnke+49-391-6263-94501liv.mahnke@lin-magdeburg.de
    Frederik Theissen+49-391-6263-94491frederik.theissen@lin-magdeburg.de
    Technical staff members and lab service  
    Diana Koch+49-391-6263-94521diana.koch@lin-magdeburg.de
    Jeannette Maiwald+49-391-6263-94521jeanette.maiwald@lin-magdeburg.de
    Dr. Antonio Reboreda Prieto+49-391-6263-94501antonio.prieto@lin-magdeburg.de
    Patricia Wenk+49-391-6263-95431patricia.wenk@lin-magdeburg.de
    Students  
    Nico Alavi  

     

  • Projects

    Projects

    Recently, we have developed the first cognitive paradigm for awake rodents that can be performed during functional magnetic resonance imaging (fMRI). In September 2018, we inaugurated a 9.4 Tesla small animal scanner and laboratory at LIN in collaboration with Eike Budinger.

    We have also conducted a behavioral study with humans in order to better characterize memory deficits, for example in patients with posttraumatic disorders. In cooperation with Emrah Düzel from the DZNE Magdeburg, we are involved in experiments with the 7 Tesla magnetic resonance tomograph.

    Within the Collaborative Research Centre 874, we dealt with the neuronal basis for familiarity whereas within the framework of the Collaborative Research Centre 779 we characterise newly identified networks in the hippocampus attributed to spatial and non-spatial memory.

     

    Our main research focus:

    • Characterization of the specific role of the MTL areas in spatial or non-spatial recognition memory depending on visual or olfactory sensory modalities (behavior, brain lesion and neuroanatomical brain imaging)
    • Evaluation of memory performance and study of the reorganization of the MTL areas following brain injury in models of amnesia (behavior, brain lesion and neuroanatomical brain imaging)
    • Characterization of memory performance and brain alterations in models of aging (behavior and neuroanatomical brain imaging)
    • Development of behavioral translational memory paradigms and fMRI cognitive translational paradigms in awake rodents (behavior, stereotactic surgery, animal fMRI)
  • Techniques

    Techniques

    We use memory tests that can be equally used in humans and animals.

    The originality of our approach is an innovative experimental approach combining a number of different techniques. We combine behavioral testing with other methods such as lesions, high-resolution neuroanatomical imaging and optogenetic techniques, as well as mutagenesis and in-vivo electrophysiology.

    We are currently elaborating our newly developed first cognitive paradigm for awake rodents in fMRI aiming at increasing the translation of human and rodent memory processes.

    Finally, we conduct behavioral human studies aiming at further characterizing memory deficits seen in depressive and patients suffering from posttraumatic disorders.


    Use of the mentioned techniques:

    • Characterization of the specific role of the MTL areas in spatial or non-spatial recognition memory depending on visual or olfactory sensory modalities (behavior, brain lesion and neuroanatomical brain imaging)
    • Evaluation of memory performance and study of the reorganization of the MTL areas following brain injury in models of amnesia (behavior, brain lesion and neuroanatomical brain imaging)
    • Characterization of memory performance and brain alterations in models of aging (behavior and neuroanatomical brain imaging)
    • Development of behavioral translational memory paradigms and fMRI cognitive translational paradigms in awake rodents (behavior, stereotactic surgery, animal fMRI
    Zu sehen ist ein durch Optogenetik erzeugtes Bild des Hippocampus, ein Apparat für Verhaltensversuche bei Mäusen und eine fMRI-Aufnahme
    At a glance: Immediate early gene (IEG)- based molecular imaging, optogenetics, behavioural tasks and functional imaging (fMRI) in awake rats.
  • Current Third Party Funds

    Current Third Party Funds

    2017-2021
    DFG grant (SFB 779) Project B17N
    „Processing spatial and non-spatial information during the retrieval of motivated memories”
    www.sfb779.de

    2019-2021
    DFG grant
    „The role of TRPC channels in path integration and firing of grid cells in the medial entorhinal cortex”

    2019-2021
    CBBS grant (funded by EFRE)
    „Dopaminergic modulation of working memory-related persistent neuronal activity in auditory cortex: from molecules to behavior“

    2017-2021
    Scholarship International Graduate School ABINEP (funded by ESF)

  • Publications

    Publications

    Key publications

    Arboit A, Reboreda A, Yoshida M. 2020. Involvement of TRPC4 and 5 Channels in Persistent Firing in Hippocampal CA1 Pyramidal Cells. Cells. 9(2):Article 365. https://doi.org/10.3390/cells9020365

    Beer Z, Vavra P, Atucha E, Rentzing K, Heinze HJ, Sauvage MM. 2018. The memory for time and space differentially engages the proximal and distal parts of the hippocampal subfields CA1 and CA3. PLoS Biology. 16(8):e2006100. https://doi.org/10.1371/journal.pbio.2006100

    Berron D, Neumann K, Maass A, Schütze H, Fliessbach K, Kiven V, Jessen F, Sauvage M, Kumaran D, Düzel E. 2018. Age-related functional changes in domain-specific medial temporal lobe pathways. Neurobiology of Aging. 65:86-97. https://doi.org/10.1016/j.neurobiolaging.2017.12.030

    Behroozi M, Chwiesko C, Ströckens F, Sauvage M, Helluy X, Peterburs J, Güntürkün O. 2018. In vivo measurement of T1 and T2 relaxation times in awake pigeon and rat brains at 7T. Magnetic Resonance in Medicine. 79(2):1090-1100. https://doi.org/10.1002/mrm.26722

    Atucha E, Karew A, Kitsukawa T, Sauvage MM. 2017. Recognition memory: Cellular evidence of a massive contribution of the LEC to familiarity and a lack of involvement of the hippocampal subfields CA1 and CA3. Hippocampus. 27(10):1083-1092. https://doi.org/10.1002/hipo.22754

    Lux V, Masseck OA, Herlitze S, Sauvage MM. 2017. Optogenetic Destabilization of the Memory Trace in CA1: Insights into Reconsolidation and Retrieval Processes. Cerebral Cortex. 27(1):841-851. https://doi.org/10.1093/cercor/bhv282

    Lux V, Atucha Trevino E, Kitsukawa T, Sauvage MM. 2016. Imaging a memory trace over half a life-time in the medial temporal lobe reveals a time-limited role of CA3 neurons in retrieval. eLife. 5:Article e11862. https://doi.org/10.7554/eLife.11862

    Nakamura NH, Sauvage MM. 2016. Encoding and reactivation patterns predictive of successful memory performance are topographically organized along the longitudinal axis of the hippocampus. Hippocampus. 26(1):67-75. https://doi.org/10.1002/hipo.22491

    Kabanova A, Pabst M, Lorkowski M, Braganza O, Boehlen A, Nikbakht N, Pothmann L, Vaswani AR, Musgrove R, Di Monte DA, Sauvage M, Beck H, Blaess S. 2015. Function and developmental origin of a mesocortical inhibitory circuit. Nature Neuroscience. 18(6):872-882. https://doi.org/10.1038/nn.4020

     

    All publications of the department

    2020

    Kessler H, Schmidt AC, James EL, Blackwell SE, von Rauchhaupt M, Harren K, Kehyayan A, Clark IA, Sauvage M, Herpertz S, Axmacher N, Holmes EA. 2020. Visuospatial computer game play after memory reminder delivered three days after a traumatic film reduces the number of intrusive memories of the experimental trauma. Journal of Behavior Therapy and Experimental Psychiatry. 67:Article 101454. https://doi.org/10.1016/j.jbtep.2019.01.006

    Arboit A, Reboreda A, Yoshida M. 2020. Involvement of TRPC4 and 5 Channels in Persistent Firing in Hippocampal CA1 Pyramidal Cells. Cells. 9(2):Article 365. https://doi.org/10.3390/cells9020365

     

    2019

    Krautwald K, Mahnke L, Angenstein F. 2019. Electrical Stimulation of the Lateral Entorhinal Cortex Causes a Frequency-Specific BOLD Response Pattern in the Rat Brain. Front Neurosci.13:539. doi: https://doi.org/10.3389/fnins.2019.00539

    Sauvage M, Kitsukawa T, Atucha E. 2019. Single-cell memory trace imaging with immediate-early genes. J Neurosci Methods. 326:108368. doi: https://doi.org/10.1016/j.jneumeth.2019.108368

    Knauer B, Yoshida M. 2019. Switching between persistent firing and depolarization block in individual rat CA1 pyramidal neurons. Hippocampus. https://doi.org/10.1002/hipo.23078

     

    2018

    Reboreda A, Theissen FM, Valero-Aracama MJ, Arboit A, Corbu MA, Yoshida M. 2018. Do TRPC channels support working memory? Comparing modulations of TRPC channels and working memory through G-protein coupled receptors and neuromodulators. Behavioural Brain Research. 354:64 - 83. https://doi.org/10.1016/j.bbr.2018.02.042

    Flasbeck V, Atucha E, Nakamura NH, Yoshida M, Sauvage MM. 2018. Spatial information is preferentially processed by the distal part of CA3: implication for memory retrieval. Behavioural Brain Research. 354:31-38. https://doi.org/10.1016/j.bbr.2018.07.023

    Beer Z, Vavra P, Atucha E, Rentzing K, Heinze HJ, Sauvage MM. 2018. The memory for time and space differentially engages the proximal and distal parts of the hippocampal subfields CA1 and CA3. PLoS Biology. 16(8):e2006100. https://doi.org/10.1371/journal.pbio.2006100

    Fernández-Fernández D, Cadaveira-Mosquera A, Rueda-Ruzafa L, Herrera-Pérez S, Veale EL, Reboreda A, Mathie A, Antonio Lamas J. 2018. Activation of TREK currents by riluzole in three subgroups of cultured mouse nodose ganglion neurons. PLoS ONE. 13(6). https://doi.org/10.1371/journal.pone.0199282

    Berron D, Neumann K, Maass A, Schütze H, Fliessbach K, Kiven V, Jessen F, Sauvage M, Kumaran D, Düzel E. 2018. Age-related functional changes in domain-specific medial temporal lobe pathways. Neurobiology of Aging. 65:86-97. https://doi.org/10.1016/j.neurobiolaging.2017.12.030

    Behroozi M, Chwiesko C, Ströckens F, Sauvage M, Helluy X, Peterburs J, Güntürkün O. 2018. In vivo measurement of T1 and T2 relaxation times in awake pigeon and rat brains at 7T. Magnetic Resonance in Medicine. 79(2):1090-1100. https://doi.org/10.1002/mrm.26722

     

    2017

    Atucha, E., Karew, A., Kitsukawa, T., & Sauvage, M. M. (2017). Recognition memory: Cellular evidence of a massive contribution of the LEC to familiarity and a lack of involvement of the hippocampal subfields CA1 and CA3. Hippocampus, 27(10), 1083-1092. doi.org/10.1002/hipo.22754

    Atucha, E., Vukojevic, V., Fornari, R. V., Ronzoni, G., Demougin, P., Peter, F., ... Roozendaal, B. (2017). Noradrenergic activation of the basolateral amygdala maintains hippocampus-dependent accuracy of remote memory. Proceedings of the National Academy of Sciences of the United States of America, 114(34), 9176-9181. doi.org/10.1073/pnas.1710819114

    Ku, S. P., Nakamura, N. H., Maingret, N., Mahnke, L., Yoshida, M., & Sauvage, M. M. (2017). Regional specific evidence for memory-load dependent activity in the dorsal subiculum and the lateral entorhinal cortex. Frontiers in Systems Neuroscience, 11, [51]. doi.org/10.3389/fnsys.2017.00051

    Cutsuridis, V., & Yoshida, M. (2017). Editorial: Memory processes in medial temporal lobe: Experimental, theoretical and computational approaches. Frontiers in Systems Neuroscience, 11, [19]. doi.org/10.3389/fnsys.2017.00019

    Giovannini, F., Knauer, B., Yoshida, M., & Buhry, L. (2017). The CAN-In network: A biologically inspired model for self-sustained theta oscillations and memory maintenance in the hippocampus. Hippocampus, 27(4), 450-463. doi.org/10.1002/hipo.22704

    Lux, V., Masseck, O. A., Herlitze, S., & Sauvage, M. M. (2017). Optogenetic Destabilization of the Memory Trace in CA1: Insights into Reconsolidation and Retrieval Processes. Cerebral Cortex, 27(1), 841-851. doi.org/10.1093/cercor/bhv282

     

    2016

    Trossbach, S. V., Bader, V., Hecher, L., Pum, M. E., Masoud, S. T., Prikulis, I., ... Korth, C. (2016). Misassembly of full-length Disrupted-in-Schizophrenia 1 protein is linked to altered dopamine homeostasis and behavioral deficits. Molecular Psychiatry, 21(11), 1561-1572. doi.org/10.1038/mp.2015.194

    Hamburg, H., Trossbach, S. V., Bader, V., Chwiesko, C., Kipar, A., Sauvage, M., ... Korth, C. (2016). Simultaneous effects on parvalbumin-positive interneuron and dopaminergic system development in a transgenic rat model for sporadic schizophrenia. Scientific Reports, 6, [34946]. doi.org/10.1038/srep34946

    Yoshida, M. (2016). Mechanisms and Roles of Intrinsic Persistent Firing in the Hippocampus. Seibutsu Butsuri, 56(5). doi.org/10.2142/biophys.56.262

    Lux, V., Atucha Trevino, E., Kitsukawa, T., & Sauvage, M. M. (2016). Imaging a memory trace over half a life-time in the medial temporal lobe reveals a time-limited role of CA3 neurons in retrieval. eLife, 5(FEBRUARY2016), [e11862]. doi.org/10.7554/eLife.11862

    Nakamura, N. H., & Sauvage, M. M. (2016). Encoding and reactivation patterns predictive of successful memory performance are topographically organized along the longitudinal axis of the hippocampus. Hippocampus, 26(1), 67-75. doi.org/10.1002/hipo.22491

     

    2015

    Valero-Aracama, M. J., Sauvage, M. M., & Yoshida, M. (2015). Environmental enrichment modulates intrinsic cellular excitability of hippocampal CA1 pyramidal cells in a housing duration and anatomical location-dependent manner. Behavioural Brain Research, 292, 209-218. doi.org/10.1016/j.bbr.2015.05.032

    Saravanan, V., Arabali, D., Jochems, A., Cui, A. X., Gootjes-Dreesbach, L., Cutsuridis, V., & Yoshida, M. (2015). Transition between encoding and consolidation/replay dynamics via cholinergic modulation of CAN current: A modeling study. Hippocampus, 25(9), 1052-1070. doi.org/10.1002/hipo.22429

    Kabanova, A., Pabst, M., Lorkowski, M., Braganza, O., Boehlen, A., Nikbakht, N., ... Blaess, S. (2015). Function and developmental origin of a mesocortical inhibitory circuit. Nature Neuroscience, 18(6), 872-882. doi.org/10.1038/nn.4020

    Jochems, A., & Yoshida, M. (2015). A robust in vivo-like persistent firing supported by a hybrid of intracellular and synaptic mechanisms. PLoS ONE, 10(4), [e0123799]. doi.org/10.1371/journal.pone.0123799

     

    2014

    Herold, C., Bingman, V. P., Ströckens, F., Letzner, S., Sauvage, M., Palomero-Gallagher, N., ... Güntürkün, O. (2014). Distribution of neurotransmitter receptors and zinc in the pigeon (Columba livia) hippocampal formation: A basis for further comparison with the mammalian hippocampus. Journal of Comparative Neurology, 522(11), 2553-2575. doi.org/10.1002/cne.23549

    Wiemers, U. S., Sauvage, M. M., & Wolf, O. T. (2014). Odors as effective retrieval cues for stressful episodes. Neurobiology of Learning and Memory, 112, 230-236. doi.org/10.1016/j.nlm.2013.10.004

    Beer, Z., Chwiesko, C., & Sauvage, M. M. (2014). Processing of spatial and non-spatial information reveals functional homogeneity along the dorso-ventral axis of CA3, but not CA1. Neurobiology of Learning and Memory, 111, 56-64. doi.org/10.1016/j.nlm.2014.03.001

     

    2013

    Beer, Z., Chwiesko, C., Kitsukawa, T., & Sauvage, M. M. (2013). Spatial and stimulus-type tuning in the LEC, MEC, POR, PrC, CA1, and CA3 during spontaneous item recognition memory. Hippocampus, 23(12), 1425-1438. doi.org/10.1002/hipo.22195

    Sauvage, M. M., Nakamura, N. H., & Beer, Z. (2013). Mapping memory function in the medial temporal lobe with the immediate-early gene Arc. Behavioural Brain Research, 254, 22-33. doi.org/10.1016/j.bbr.2013.04.048

    Wiemers, U. S., Sauvage, M. M., Schoofs, D., Hamacher-Dang, T. C., & Wolf, O. T. (2013). What we remember from a stressful episode. Psychoneuroendocrinology, 38(10), 2268-2277. doi.org/10.1016/j.psyneuen.2013.04.015

    Nakamura, N. H., Flasbeck, V., Maingret, N., Kitsukawa, T., & Sauvage, M. M. (2013). Proximodistal segregation of nonspatial information in CA3: Preferential recruitment of a proximal CA3-distal CA1 network in nonspatial recognition memory. Journal of Neuroscience, 33(28), 11506-11514. doi.org/10.1523/JNEUROSCI.4480-12.2013

     

    2012

    Eichenbaum, H., Sauvage, M., Fortin, N., Robitsek, J., & Komorowski, R. (2012). A Comparative Analysis of Episodic Memory: Cognitive Mechanisms and Neural Substrates. in The Oxford Handbook of Comparative Cognition Oxford University Press. doi.org/10.1093/oxfordhb/9780195392661.013.0017

    Eichenbaum, H., Sauvage, M., Fortin, N., Komorowski, R., & Lipton, P. (2012). Towards a functional organization of episodic memory in the medial temporal lobe. Neuroscience and Biobehavioral Reviews, 36(7), 1597-1608. doi.org/10.1016/j.neubiorev.2011.07.006

    Place, R., Lykken, C., Beer, Z., Suh, J., McHugh, T. J., Tonegawa, S., ... Sauvage, M. M. (2012). NMDA signaling in CA1 mediates selectively the spatial component of episodic memory. Learning and Memory, 19(4), 164-169. doi.org/10.1101/lm.025254.111

    Sauvage, M. M. (2012). Neural substrates of recollection and familiarity: Further bridging human and animal recognition memory using translational paradigms. in Psychology of Memory (S. 155-182). Nova Science Publishers, Inc..

     

    2010

    Sauvage, M. M., Beer, Z., Ekovich, M., Ho, L., & Eichenbaum, H. (2010). The caudal medial entorhinal cortex: A selective role in recollection-based recognition memory. Journal of Neuroscience, 30(46), 15695-15699. doi.org/10.1523/JNEUROSCI.4301-10.2010

    Sauvage, M. M. (2010). ROC in animals: Uncovering the neural substrates of recollection and familiarity in episodic recognition memory. Consciousness and Cognition, 19(3), 816-828. doi.org/10.1016/j.concog.2010.06.023

    Eichenbaum, H., Fortin, N., Sauvage, M., Robitsek, R. J., & Farovik, A. (2010). An animal model of amnesia that uses Receiver Operating Characteristics (ROC) analysis to distinguish recollection from familiarity deficits in recognition memory. Neuropsychologia, 48(8), 2281-2289. doi.org/10.1016/j.neuropsychologia.2009.09.015

    Sauvage, M. M., Beer, Z., & Eichenbaum, H. (2010). Recognition memory: Adding a response deadline eliminates recollection but spares familiarity. Learning and Memory, 17(2), 104-108. doi.org/10.1101/lm.1647710

  • Conference series “Functional Architecture of Memory”

    Conference series “Functional Architecture of Memory”

    The conference series focuses on bringing new insights on major controversies in recognition memory as well as bridging further human and animal memory. The event is organized by our department in a two-year cycle.

    Twenty of the world's leading experts in medial temporal lobe research and memory function will discuss their findings from behavioral studies, imaging techniques, electrophysiology, mutagenesis, and computer techniques.

    The next FAM conference will take place from 25. - 27. November 2020.

    All relevant information will be available in time under this link: https://www.lin-magdeburg.de/forschung/konferenzen/functional-architecture-of-memory

     

    Speakers of the FAM Conference 2018

    Speakers of the FAM Conference 2016

    Impression von der FAM-Konferenz
  • Cooperations

    Cooperations

    International/National

     

    Magdeburg:

  • Media Coverage

    Media Coverage

Working Groups

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