Department Functional Architecture of Memory
The temporal lobe is an important brain structure in the memory process. If these brain regions are damaged, serious memory disorders occur - often in older people and in patients with memory loss.
The focus of our research is on identifying the specific contribution of the different areas of the medial temporal lobe to memory performance in terms of time and space. In addition, the memory process in relation to familiarity/recollection and encoding/retrieval are the focus of our research interest, as is the characterization of changes in brain areas within the aging process.
Selected publications
- Beer Z, Vavra P, Atucha E, Rentzing K, Heinze HJ, Sauvage MM. 2018. The memory for time and space differentially engages the proximal and distal parts of the hippocampal subfields CA1 and CA3. PLoS Biology. 16(8):e2006100.
- Lux V, Atucha Trevino E, Kitsukawa T, Sauvage MM. 2016. Imaging a memory trace over half a life-time in the medial temporal lobe reveals a time-limited role of CA3 neurons in retrieval. eLife. e11862.
- Nakamura NH, Flasbeck V, Maingret N, Kitsukawa T, & Sauvage MM. 2013. Proximodistal segregation of nonspatial information in CA3: Preferential recruitment of a proximal CA3-distal CA1 network in nonspatial recognition memory. Journal of Neuroscience, 33(28), 11506-11514.
- Sauvage MM, Fortin N, Owens C, Yonelinas AP, Eichenbaum H. 2008. Recognition memory: opposite effects of hippocampal damage on recollection and familiarity. Nature Neuroscience, 11(1): 16-8.
- Head
Head
After a PhD on the effect of chronic stress on memory function at the MPI in Munich, Germany (Holsboer/ Steckler lab), Magdalena Sauvage did postdocs at MIT (Graybiel lab) and Boston University (Eichenbaum lab), followed by a Research Assistant Professorship in Eichenbaum lab in Boston USA and an Associate Professorship at the RUB (W2; Bochum, Germany).
Since 2016 Professor Sauvage has headed the Functional Architecture of Memory Department and is one of the co-directors of the LIN.
The originality of our approach is an innovative experimental approach combining a number of different techniques. We combine behavioral testing with other methods such as lesions, high-resolution neuroanatomical imaging and optogenetic techniques, as well as mutagenesis and in-vivo electrophysiology.
- Members
Members
Head Prof. Dr. Magdalena Sauvage +49-391-6263-94011 magdalena.sauvage@lin-magdeburg.de Secretary Jessica Levin +49-391-6263-94531 jessica.levin@lin-magdeburg.de Group leader Dr. Motoharu Yoshida +49-391-6263-94011 motoharu.yoshida@lin-magdeburg.de Postdoc Dr. Shih-Pi Ku +49-391-6263-94501 shih-pi.ku@lin-magdeburg.de Dr. Erika Atucha Trevino +49-391-6263-94501 erika.trevino@lin-magdeburg.de PhD students Yacine Brahimi +49-391-6263-94491 yacine.brahimi@lin-magdeburg.de Simone Calabrese +49-391-6263-94501 simone.calabrese@lin-magdeburg.de Liv Mahnke +49-391-6263-94501 liv.mahnke@lin-magdeburg.de Frederik Theissen +49-391-6263-94491 frederik.theissen@lin-magdeburg.de Technical staff members and lab service Diana Koch +49-391-6263-94521 diana.koch@lin-magdeburg.de Jeannette Maiwald +49-391-6263-94521 jeanette.maiwald@lin-magdeburg.de Dr. Antonio Reboreda Prieto +49-391-6263-94501 antonio.prieto@lin-magdeburg.de Students Nico Alavi Yu-Hsin Chang - Projects
Projects
Recently, we have developed the first cognitive paradigm for awake rodents that can be performed during functional magnetic resonance imaging (fMRI). In September 2018, we inaugurated a 9.4 Tesla small animal scanner and laboratory at LIN in collaboration with Eike Budinger.
We have also conducted a behavioral study with humans in order to better characterize memory deficits, for example in patients with posttraumatic disorders. In cooperation with Emrah Düzel from the DZNE Magdeburg, we are involved in experiments with the 7 Tesla magnetic resonance tomograph.
Within the Collaborative Research Centre 874, we dealt with the neuronal basis for familiarity whereas within the framework of the Collaborative Research Centre 779 we characterise newly identified networks in the hippocampus attributed to spatial and non-spatial memory.
Our main research focus:
- Characterization of the specific role of the MTL areas in spatial or non-spatial recognition memory depending on visual or olfactory sensory modalities (behavior, brain lesion and neuroanatomical brain imaging)
- Evaluation of memory performance and study of the reorganization of the MTL areas following brain injury in models of amnesia (behavior, brain lesion and neuroanatomical brain imaging)
- Characterization of memory performance and brain alterations in models of aging (behavior and neuroanatomical brain imaging)
- Development of behavioral translational memory paradigms and fMRI cognitive translational paradigms in awake rodents (behavior, stereotactic surgery, animal fMRI)
- Techniques
Techniques
We use memory tests that can be equally used in humans and animals.
The originality of our approach is an innovative experimental approach combining a number of different techniques. We combine behavioral testing with other methods such as lesions, high-resolution neuroanatomical imaging and optogenetic techniques, as well as mutagenesis and in-vivo electrophysiology.
We are currently elaborating our newly developed first cognitive paradigm for awake rodents in fMRI aiming at increasing the translation of human and rodent memory processes.
Finally, we conduct behavioral human studies aiming at further characterizing memory deficits seen in depressive and patients suffering from posttraumatic disorders.
Use of the mentioned techniques:- Characterization of the specific role of the MTL areas in spatial or non-spatial recognition memory depending on visual or olfactory sensory modalities (behavior, brain lesion and neuroanatomical brain imaging)
- Evaluation of memory performance and study of the reorganization of the MTL areas following brain injury in models of amnesia (behavior, brain lesion and neuroanatomical brain imaging)
- Characterization of memory performance and brain alterations in models of aging (behavior and neuroanatomical brain imaging)
- Development of behavioral translational memory paradigms and fMRI cognitive translational paradigms in awake rodents (behavior, stereotactic surgery, animal fMRI
At a glance: Immediate early gene (IEG)- based molecular imaging, optogenetics, behavioural tasks and functional imaging (fMRI) in awake rats. - Current Third Party Funds
Current Third Party Funds
2017-2021
DFG grant (SFB 779) Project B17N
„Processing spatial and non-spatial information during the retrieval of motivated memories”
www.sfb779.de
2019-2021
DFG grant
„The role of TRPC channels in path integration and firing of grid cells in the medial entorhinal cortex”
2019-2021
CBBS grant (funded by EFRE)
„Dopaminergic modulation of working memory-related persistent neuronal activity in auditory cortex: from molecules to behavior“
2017-2021
Scholarship International Graduate School ABINEP (funded by ESF) - Publications
Publications
Key publications
Beer Z, Vavra P, Atucha E, Rentzing K, Heinze HJ, Sauvage MM. 2018. The memory for time and space differentially engages the proximal and distal parts of the hippocampal subfields CA1 and CA3. PLoS Biology. 16(8):e2006100. https://doi.org/10.1371/journal.pbio.2006100
Behroozi M, Chwiesko C, Ströckens F, Sauvage M, Helluy X, Peterburs J, Güntürkün O. 2018. In vivo measurement of T1 and T2 relaxation times in awake pigeon and rat brains at 7T. Magnetic Resonance in Medicine. 79(2):1090-1100. https://doi.org/10.1002/mrm.26722
Lux V, Masseck OA, Herlitze S, Sauvage MM. 2017. Optogenetic Destabilization of the Memory Trace in CA1: Insights into Reconsolidation and Retrieval Processes. Cerebral Cortex. 27(1):841-851. https://doi.org/10.1093/cercor/bhv282
Lux V, Atucha Trevino E, Kitsukawa T, Sauvage MM. 2016. Imaging a memory trace over half a life-time in the medial temporal lobe reveals a time-limited role of CA3 neurons in retrieval. eLife. 5(FEBRUARY2016):Article e11862. https://doi.org/10.7554/eLife.11862
Nakamura NH, Sauvage MM. 2016. Encoding and reactivation patterns predictive of successful memory performance are topographically organized along the longitudinal axis of the hippocampus. Hippocampus. 26(1):67-75. https://doi.org/10.1002/hipo.22491
Sauvage MM, Beer Z, Ekovich M, Ho L, Eichenbaum H. 2010. The caudal medial entorhinal cortex: A selective role in recollection-based recognition memory. Journal of Neuroscience. 30(46):15695-15699. https://doi.org/10.1523/JNEUROSCI.4301-10.2010
Sauvage M, Fortin N, Owens C, Yonelinas AP, Eichenbaum H. 2008. Recognition memory: opposite effects of hippocampal damage on recollection and familiarity. Nature Neuroscience. 11(1): 16-8.
All publications of the department
2020
Kessler H, Schmidt AC, James EL, Blackwell SE, von Rauchhaupt M, Harren K, Kehyayan A, Clark IA, Sauvage M, Herpertz S, Axmacher N, Holmes EA. 2020. Visuospatial computer game play after memory reminder delivered three days after a traumatic film reduces the number of intrusive memories of the experimental trauma. Journal of Behavior Therapy and Experimental Psychiatry. 67:Article 101454. https://doi.org/10.1016/j.jbtep.2019.01.006
Arboit A, Reboreda A, Yoshida M. 2020. Involvement of TRPC4 and 5 Channels in Persistent Firing in Hippocampal CA1 Pyramidal Cells. Cells. 9(2):Article 365. https://doi.org/10.3390/cells9020365
2019
Knauer B, Yoshida M. 2019. Switching between persistent firing and depolarization block in individual rat CA1 pyramidal neurons. Hippocampus. 29(9):817-835. https://doi.org/10.1002/hipo.23078
Krautwald K, Mahnke L, Angenstein F. 2019. Electrical Stimulation of the Lateral Entorhinal Cortex Causes a Frequency-Specific BOLD Response Pattern in the Rat Brain. Frontiers in Neuroscience. 13(MAY):Article 539. https://doi.org/10.3389/fnins.2019.00539
Sauvage M, Kitsukawa T, Atucha E. 2019. Single-cell memory trace imaging with immediate-early genes. Journal of Neuroscience Methods. 326:108368. https://doi.org/10.1016/j.jneumeth.2019.108368
2018
Beer Z, Vavra P, Atucha E, Rentzing K, Heinze HJ, Sauvage MM. 2018. The memory for time and space differentially engages the proximal and distal parts of the hippocampal subfields CA1 and CA3. PLoS Biology. 16(8):e2006100. https://doi.org/10.1371/journal.pbio.2006100
Behroozi M, Chwiesko C, Ströckens F, Sauvage M, Helluy X, Peterburs J, Güntürkün O. 2018. In vivo measurement of T1 and T2 relaxation times in awake pigeon and rat brains at 7T. Magnetic Resonance in Medicine. 79(2):1090-1100. https://doi.org/10.1002/mrm.26722
Berron D, Neumann K, Maass A, Schütze H, Fliessbach K, Kiven V, Jessen F, Sauvage M, Kumaran D, Düzel E. 2018. Age-related functional changes in domain-specific medial temporal lobe pathways. Neurobiology of Aging. 65:86-97. https://doi.org/10.1016/j.neurobiolaging.2017.12.030
Fernández-Fernández D, Cadaveira-Mosquera A, Rueda-Ruzafa L, Herrera-Pérez S, Veale EL, Reboreda A, Mathie A, Antonio Lamas J. 2018. Activation of TREK currents by riluzole in three subgroups of cultured mouse nodose ganglion neurons. PLoS ONE. 13(6). https://doi.org/10.1371/journal.pone.0199282
Flasbeck V, Atucha E, Nakamura NH, Yoshida M, Sauvage MM. 2018. Spatial information is preferentially processed by the distal part of CA3: implication for memory retrieval. Behavioural Brain Research. 354:31-38. https://doi.org/10.1016/j.bbr.2018.07.023
Reboreda A, Theissen FM, Valero-Aracama MJ, Arboit A, Corbu MA, Yoshida M. 2018. Do TRPC channels support working memory? Comparing modulations of TRPC channels and working memory through G-protein coupled receptors and neuromodulators. Behavioural Brain Research. 354:64 - 83. https://doi.org/10.1016/j.bbr.2018.02.042
2017
Atucha E, Karew A, Kitsukawa T, Sauvage MM. 2017. Recognition memory: Cellular evidence of a massive contribution of the LEC to familiarity and a lack of involvement of the hippocampal subfields CA1 and CA3. Hippocampus. 27(10):1083-1092. https://doi.org/10.1002/hipo.22754
Atucha E, Vukojevic V, Fornari RV, Ronzoni G, Demougin P, Peter F, Atsak P, Coolen MW, Papassotiropoulos A, McGaugh JL, de Quervain DJF, Roozendaal B. 2017. Noradrenergic activation of the basolateral amygdala maintains hippocampus-dependent accuracy of remote memory. Proceedings of the National Academy of Sciences of the United States of America. 114(34):9176-9181. https://doi.org/10.1073/pnas.1710819114
Cutsuridis V, Yoshida M. 2017. Editorial: Memory processes in medial temporal lobe: Experimental, theoretical and computational approaches. Frontiers in Systems Neuroscience. 11:Article 19. https://doi.org/10.3389/fnsys.2017.00019
Giovannini F, Knauer B, Yoshida M, Buhry L. 2017. The CAN-In network: A biologically inspired model for self-sustained theta oscillations and memory maintenance in the hippocampus. Hippocampus. 27(4):450-463. https://doi.org/10.1002/hipo.22704
Ku SP, Nakamura NH, Maingret N, Mahnke L, Yoshida M, Sauvage MM. 2017. Regional specific evidence for memory-load dependent activity in the dorsal subiculum and the lateral entorhinal cortex. Frontiers in Systems Neuroscience. 11:Article 51. https://doi.org/10.3389/fnsys.2017.00051
Lux V, Masseck OA, Herlitze S, Sauvage MM. 2017. Optogenetic Destabilization of the Memory Trace in CA1: Insights into Reconsolidation and Retrieval Processes. Cerebral Cortex. 27(1):841-851. https://doi.org/10.1093/cercor/bhv282
2016
Hamburg H, Trossbach SV, Bader V, Chwiesko C, Kipar A, Sauvage M, Crum WR, Vernon AC, Bidmon HJ, Korth C. 2016. Simultaneous effects on parvalbumin-positive interneuron and dopaminergic system development in a transgenic rat model for sporadic schizophrenia. Scientific Reports. 6:Article 34946. https://doi.org/10.1038/srep34946
Lux V, Atucha Trevino E, Kitsukawa T, Sauvage MM. 2016. Imaging a memory trace over half a life-time in the medial temporal lobe reveals a time-limited role of CA3 neurons in retrieval. eLife. 5(FEBRUARY2016):Article e11862. https://doi.org/10.7554/eLife.11862
Nakamura NH, Sauvage MM. 2016. Encoding and reactivation patterns predictive of successful memory performance are topographically organized along the longitudinal axis of the hippocampus. Hippocampus. 26(1):67-75. https://doi.org/10.1002/hipo.22491
Trossbach SV, Bader V, Hecher L, Pum ME, Masoud ST, Prikulis I, Schäble S, de Souza Silva MA, Su P, Boulat B, Chwiesko C, Poschmann G, Stühler K, Lohr KM, Stout KA, Oskamp A, Godsave SF, Müller-Schiffmann A, Bilzer T, Steiner H, Peters PJ, Bauer A, Sauvage M, Ramsey AJ, Miller GW, Liu F, Seeman P, Brandon NJ, Huston JP, Korth C. 2016. Misassembly of full-length Disrupted-in-Schizophrenia 1 protein is linked to altered dopamine homeostasis and behavioral deficits. Molecular Psychiatry. 21(11):1561-1572. https://doi.org/10.1038/mp.2015.194
Yoshida M. 2016. Mechanisms and Roles of Intrinsic Persistent Firing in the Hippocampus. Seibutsu Butsuri. 56(5). https://doi.org/10.2142/biophys.56.262
2015
Jochems A, Yoshida M. 2015. A robust in vivo-like persistent firing supported by a hybrid of intracellular and synaptic mechanisms. PLoS ONE. 10(4):Article e0123799. https://doi.org/10.1371/journal.pone.0123799
Kabanova A, Pabst M, Lorkowski M, Braganza O, Boehlen A, Nikbakht N, Pothmann L, Vaswani AR, Musgrove R, Di Monte DA, Sauvage M, Beck H, Blaess S. 2015. Function and developmental origin of a mesocortical inhibitory circuit. Nature Neuroscience. 18(6):872-882. https://doi.org/10.1038/nn.4020
Saravanan V, Arabali D, Jochems A, Cui AX, Gootjes-Dreesbach L, Cutsuridis V, Yoshida M. 2015. Transition between encoding and consolidation/replay dynamics via cholinergic modulation of CAN current: A modeling study. Hippocampus. 25(9):1052-1070. https://doi.org/10.1002/hipo.22429
Valero-Aracama MJ, Sauvage MM, Yoshida M. 2015. Environmental enrichment modulates intrinsic cellular excitability of hippocampal CA1 pyramidal cells in a housing duration and anatomical location-dependent manner. Behavioural Brain Research. 292:209-218. https://doi.org/10.1016/j.bbr.2015.05.032
2014
Beer Z, Chwiesko C, Sauvage MM. 2014. Processing of spatial and non-spatial information reveals functional homogeneity along the dorso-ventral axis of CA3, but not CA1. Neurobiology of Learning and Memory. 111:56-64. https://doi.org/10.1016/j.nlm.2014.03.001
Herold C, Bingman VP, Ströckens F, Letzner S, Sauvage M, Palomero-Gallagher N, Zilles K, Güntürkün O. 2014. Distribution of neurotransmitter receptors and zinc in the pigeon (Columba livia) hippocampal formation: A basis for further comparison with the mammalian hippocampus. Journal of Comparative Neurology. 522(11):2553-2575. https://doi.org/10.1002/cne.23549
Wiemers US, Sauvage MM, Wolf OT. 2014. Odors as effective retrieval cues for stressful episodes. Neurobiology of Learning and Memory. 112:230-236. https://doi.org/10.1016/j.nlm.2013.10.004
2013
Beer Z, Chwiesko C, Kitsukawa T, Sauvage MM. 2013. Spatial and stimulus-type tuning in the LEC, MEC, POR, PrC, CA1, and CA3 during spontaneous item recognition memory. Hippocampus. 23(12):1425-1438. https://doi.org/10.1002/hipo.22195
Nakamura NH, Flasbeck V, Maingret N, Kitsukawa T, Sauvage MM. 2013. Proximodistal segregation of nonspatial information in CA3: Preferential recruitment of a proximal CA3-distal CA1 network in nonspatial recognition memory. Journal of Neuroscience. 33(28):11506-11514. https://doi.org/10.1523/JNEUROSCI.4480-12.2013
Sauvage MM, Nakamura NH, Beer Z. 2013. Mapping memory function in the medial temporal lobe with the immediate-early gene Arc. Behavioural Brain Research. 254:22-33. https://doi.org/10.1016/j.bbr.2013.04.048
Wiemers US, Sauvage MM, Schoofs D, Hamacher-Dang TC, Wolf OT. 2013. What we remember from a stressful episode. Psychoneuroendocrinology. 38(10):2268-2277. https://doi.org/10.1016/j.psyneuen.2013.04.015
2012
Eichenbaum H, Sauvage M, Fortin N, Komorowski R, Lipton P. 2012. Towards a functional organization of episodic memory in the medial temporal lobe. Neuroscience and Biobehavioral Reviews. 36(7):1597-1608. https://doi.org/10.1016/j.neubiorev.2011.07.006
Eichenbaum H, Sauvage M, Fortin N, Robitsek J, Komorowski R. 2012. A Comparative Analysis of Episodic Memory: Cognitive Mechanisms and Neural Substrates. In The Oxford Handbook of Comparative Cognition. Oxford University Press. https://doi.org/10.1093/oxfordhb/9780195392661.013.0017
Place R, Lykken C, Beer Z, Suh J, McHugh TJ, Tonegawa S, Eichenbaum H, Sauvage MM. 2012. NMDA signaling in CA1 mediates selectively the spatial component of episodic memory. Learning and Memory. 19(4):164-169. https://doi.org/10.1101/lm.025254.111
Sauvage MM. 2012. Neural substrates of recollection and familiarity: Further bridging human and animal recognition memory using translational paradigms. In Psychology of Memory. Nova Science Publishers, Inc. pp. 155-182.
2010
Eichenbaum H, Fortin N, Sauvage M, Robitsek RJ, Farovik A. 2010. An animal model of amnesia that uses Receiver Operating Characteristics (ROC) analysis to distinguish recollection from familiarity deficits in recognition memory. Neuropsychologia. 48(8):2281-2289. https://doi.org/10.1016/j.neuropsychologia.2009.09.015
Sauvage MM, Beer Z, Eichenbaum H. 2010. Recognition memory: Adding a response deadline eliminates recollection but spares familiarity. Learning and Memory. 17(2):104-108. https://doi.org/10.1101/lm.1647710
Sauvage MM, Beer Z, Ekovich M, Ho L, Eichenbaum H. 2010. The caudal medial entorhinal cortex: A selective role in recollection-based recognition memory. Journal of Neuroscience. 30(46):15695-15699. https://doi.org/10.1523/JNEUROSCI.4301-10.2010
Sauvage MM. 2010. ROC in animals: Uncovering the neural substrates of recollection and familiarity in episodic recognition memory. Consciousness and Cognition. 19(3):816-828. https://doi.org/10.1016/j.concog.2010.06.023
- Conference series “Functional Architecture of Memory”
Conference series “Functional Architecture of Memory”
The conference series focuses on bringing new insights on major controversies in recognition memory as well as bridging further human and animal memory. The event is organized by our department in a two-year cycle.
Twenty of the world's leading experts in medial temporal lobe research and memory function will discuss their findings from behavioral studies, imaging techniques, electrophysiology, mutagenesis, and computer techniques.
The next FAM conference will take place from 26. - 28. Mai 2021.
All relevant information will be available in time under this link: https://www.lin-magdeburg.de/forschung/konferenzen/functional-architecture-of-memory
- Cooperations
Cooperations
International/National
- Dr. Susumu Tonegawa (MIT/RIKEN, USA)
- Dr. Jozsef Csicsvari (IST, Austria),
- Dr. Takashi Kitsukawa (Osaka University, Japan)
- Prof. Dr. Kitamura (Northwestern U, USA)
- Prof. Dr. Mathias Hoehn (MPI for Neurological Research, Cologne)
- Prof. Dr. Stephan Herpertz (Medical Faculty, LWL, Clinic for Psychosomatic Medicine and Psychotherapy, Bochum)
- Dr. Andrew Yonelinas (UCDavis, USA)
- Prof. Dr. Dr. Onur Güntürkün and Prof. Dr. Boris Suchan (Faculty of Psychology, RUB, Germany)
- Prof. Dr. Michael Yassa (Irvine, USA)
- Dr. Sheena Josselyn (Sickkids, Toronto, Canada)
Magdeburg:
- Prof. Dr. Emrah Düzel (DZNE)
- Prof. Dr. Frank Angenstein (DZNE)
- Dr. Eike Budinger (LIN)
- Dr. Motoharu Yoshida (LIN/DZNE)
- Media Coverage
Media Coverage
- Wie erinnern wir uns an unseren ersten Schultag?, MDR Wissen
- How Does The Brain Manage Everyday Memory Events?, Science Trend
- Gedächtnisforschung in Magdeburg, MDR aktuell
- Hirnforschung spielerisch erklärt, General-Anzeiger Magdeburg