Department Cellular Neuroscience

 

How does the brain learn, store, and recall specific locations and events? And what causes these memory processes to malfunction in disease?

We study how neural computations on the cellular and circuit level underlie memory guided behavior and cognitive dysfunction.

 

Research topics

  • cracking the neuronal code

    cracking the neuronal code

    We want to understand how hippocampal neurons in the subiculum generate the neuronal code of action potential sequences that is transmitted to other brain regions such as the cortex. This action potential code is densely packed with information on the spatial position, self-motion, motivation, salience and is tuned by prior experience via synaptic plasticity. For cracking this hippocampal output code, we monitor synaptic input of multiple kinds during the behavior. We then use computational modeling to predict the conversion of input to output and finally test our predictions by recording directly from single neurons with synaptic resolution during behavior (supported by ERC consolidator grant SUB-D-Code). Dennis Dalügge, Oliver Barnstedt, Pavol Bauer, Hiroshi Kaneko

     

  • using artificial intelligence to detect features in neural activity and behavior

    using artificial intelligence to detect features in neural activity and behavior

    We are using machine vision and learning to classify behavior. The application of artificial intelligence based tools has the potential to revolutionize research on neural correlates of behavior. In particular, we classify the way an animal changes its pose and interacts with an environment in an unsupervised manner. We are convinced that high temporal resolution unsupervised behavioral classification will be a first step allowing us to correlate behavioral features with neural activity patterns. The second step is extracting scientific understanding and detecting causal relationships within these large behavior-correlated neural activity imaging data sets. In other words, we want to understand biological neural networks by using artificial neural networks as a tool.  (supported by EFRE funding, Pavol Bauer, Kevin Luxem, Johannes Kürsch)

     

  • understanding the diversity of neurons

    understanding the diversity of neurons

    For most brain areas a comprehensive understanding of the cell clusters forming the neural circuits is currently absent. In collaboration with Nelson Spruston (HHMI Janelia), Mark Cembrowski (University of Vancouver and the Janelia Quantitative Genomics Unit we use single-cell RNA sequencing and multiplexed in situ hybridization for transcriptomic profiling of cell types. A brain region of highest interest is the medial septum. It is a brain region that controls hippocampal memory circuits. We have set up an innovative framework of bioinformatics analyses to identify genetically-defined cell populations. In combination with viral tracing tools we further reveal specific hippocampus-projecting clusters and dissect their function during behavior (supported by HHMI Janelia Visitor Project) Stefano Pupe

     

  • understanding vulnerability and resilience of neural circuits to cognitive dysfunction

    understanding vulnerability and resilience of neural circuits to cognitive dysfunction

    We are investigating how hippocampal memory circuits and individual neurons within these circuits respond to progressive pathological challenges. Here we have set a focus on the accumulation of amyloid beta, which can be observed in human Alzheimer patients and in advanced physiological aging. We found a computational principle explaining why reduced dendritic size in the response to pathology results in higher neuronal.  By using computational modeling, we could understand how neuronal structural changes define electrical properties of dendrites and entire neurons. On the circuit level, we are investigating how hippocampal inhibitory and excitatory neurons interact in microcircuits and how altered interneuron function contributes to the malfunction of learning and memory processes (supported by SFB 1089 project B01) Liudmila Sosulina, Hiroshi Kaneko

     

  • investigating the subcortical modulation of memory circuits

    investigating the subcortical modulation of memory circuits

    Subcortical areas form the core of our brain, they are involved in complex activities such as memory, emotion, pleasure, arousal and hormone production. They act as hubs by relaying and modulating information passing to different areas of the brain including the hippocampus. We are trying to gain a better understanding on how hippocampal circuits are controlled by direct and indirect subcortical modulation from the medial septum, the locus coeruleus and the ventral tegmental area. The medial septum is a basal forebrain region that is reciprocally connected with the hippocampal formation, where it orchestrates microcircuit activation and oscillatory activity during different behavioral states. It is known as a main source of Acetylcholine, which is released by septo-hippocampal afferents during learning and memory processes. We have discovered that, in addition to cholinergic projections, glutamatergic and GABAergic septo-hippocampal projections play a key role in the control of activity levels of hippocampal neurons during memory guided navigation. The medial septum is an important network hub, it integrates behavioral state dependent input from locus coeruleus and channels specific information to the hippocampus and other memory-relevant brain regions. We want to better understand the multitude of medial septal functions during behavior (supported by SFB 1089 subproject C05) –  Petra Mocellin, Liudmila Sosulina

     

 

The video shows a 3D-rendering of the medial septum and diagonal Band of Broca  in a cleared mouse brain. VGluT2-positive neurons are labeled in red, green labeled neurons are retrogradely traced from MEC by using RABVΔG-EGFP.

The department

  • News

    News

    New preprint on mechanisms of neuronal hyperexcitability and network dysfunction in Alzheimer’s disease

    Our new preprint is out. It ist the result of a great collaboration with Martin Fuhrmann’s (DZNE ) and Michael Rowan’s (Trinity College, Dublin) labs. Liudmila Sosulina and Manuel Mittag analyzed the hippocampal micronetwork in a rat model of AD at an early disease stage at the beginning of extracellular amyloid beta (Aβ) deposition. They are the first to show with two-photon Ca2+-imaging in vivo and patch-clamp physiology that neuronal hyperexcitability can be observed in the hippocampus of rats and is present at very early stages. They show that mechanistically this micronetwork dysfunction is due to changes of intrinsic neuronal excitability, rather than reduced inhibitory synaptic transmission, which sets in at later stages. Our data support the view that altered intrinsic excitability of CA1 neurons may precede inhibitory dysfunction at an early stage of disease progression.

     

    Release of new preprint including research code

    We are excited to share a new preprint entitled “Identifying Behavioral Structure from Deep Variational Embeddings of Animal Motion” that is available at BioRxiv.

    In this work we present a novel machine learning framework for discovery of the latent structure of animal behavior given data from markerless pose estimation entitled Variational Animal Motion Embedding (VAME). VAME clusters the time series data into “behavioral motifs”, which are stereotypical behavioral patterns that occur repeatedly in free behavior. The structure of behavior is then represented in the distribution of motifs and the probability of transitions between them. In the preprint we show that this information is sensitive enough to serve as a basis for classification of mice according to its behavior phenotypes. This can be done even for subtle behavioral differences, which human experts are unable to detect from the video capture.

  • Head

    Head

    Since January 2020 Stefan Remy is the scientific director of the LIN and the head of the Department of Cellular Neuroscience. He is also appointed as Professor of Molecular and Cellular Neurobiology at the Otto von Guericke University, Medical Faculty in Magdeburg.

    Stefan Remy’s department investigates how neural computations on the cellular and circuit level underlie memory guided behavior and cognitive dysfunction. Within the department biologists, mathematicians and computer scientists collaborate to extract scientific understanding from multidimensional behavioral and neurophysiological data sets.

    He obtained the doctoral degree at the University of Bonn in 2003 and then worked from 2003-2005 as postdoc with Heinz Beck at the Department of Epileptology (Head: Christian E. Elger). As an Alexander-von-Humboldt fellow he joined the Department of Neurobiology and Physiology at Northwestern University, Evanston, in 2005. There he worked with Nelson Spruston on dendritic excitability and synaptic plasticity. In 2007 he continued his postdoctoral training with Heinz Beck in Bonn, where he started his own research group in 2009 funded by the state of NRW. From 2010 he headed a research group at the German Center of Neurodegenerative Diseases Bonn (Head: Pierluigi Nicotera) before moving to Magdeburg in 2020.


    There are places I remember
    All my life though some have changed
    Some forever not for better
    Some have gone and some remain
    All these places have their moments
    With lovers and friends I still can recall
    Some are dead and some are living
    In my life I've loved them all.

    (John Lennon/ Paul McCartney)

     

    My research philosophy is explained here in my inaugural lecture.

     

  • Members

    Members

    Head  
    Prof. Dr. Stefan Remy+49 391 6263 92421, 92411, 93311Stefan.Remy@lin-magdeburg.de
    Assistant  
    Juliane Jäger  +49 391 6263 92411Juliane.Jaeger@lin-magdeburg.de

    Research group leaders

      

    Prof. Dr. Stefan Remy (Cells and Circuits)

    +49 391 6263 92421, 92411, 93311Stefan.Remy@lin-magdeburg.de

    Dr. Pavol Bauer (Neural Data Science)

    +49 391 6263 9 3361Pavol.Bauer@lin-magdeburg.de

    Postdocs

      

    Dr. Oliver Barnstedt (DZNE Bonn)

      

    Dr. Hiroshi Kaneko (staff scientist)

    +49 391 6263 93371Hiroshi.Kaneko@lin-magdeburg.de

    Dr. Stefano Pupe

    +49 391 6263 92411Stefano.Pupe@lin-magdeburg.de

    Dr. Liudmila Sosulina (staff scientist)

    +49 391 6263 93371Liudmila.Sosulina@lin-magdeburg.de

    PhD students

      

    Petra Mocellin

    +49 391 6263 9 2411Petra.Mocellin@lin-magdeburg.de

    Dennis Dalügge

      

    Kevin Luxem

    +49 391 6263 93361Kevin.Luxem@lin-magdeburg.de

    Lab coordinators/Research Technicians

      
    Silvia Vieweg+49 391 6263 93481vieweg@lin-magdeburg.de

    Visitors/Guests

      

    Dr. Sanja Mikulovic (Swedish Research Council)

    +49 391 6263 93171Sanja.Mikulovic@lin-magdeburg.de

    Other scientific contributors

      

    Benedikt Auer (Stud. Hilfskraft)

      

    Johannes Kürsch (Stud. Hilfskraft)

      

    Dr. Falko Fuhrmann (Lab consultant)

      
  • Publications

    Publications

    Key publications

    Luxem K, Fuhrmann F, Kürsch J, Remy S*, Bauer P*. 2020. Identifying Behavioral Structure from Deep Variational Embeddings of Animal Motion. BioRxiv. https://doi.org/10.1101/2020.05.14.095430 * shared senior authorship

    Justus D, Dalügge D, Bothe S, Fuhrmann F, Hannes C, Kaneko H, Friedrichs D, Sosulina L, Schwarz I, Elliott DA, Schoch S, Bradke F, Schwarz MK, Remy S. 2017. Glutamatergic synaptic integration of locomotion speed via septoentorhinal projections. Nature Neuroscience. 20(1):16-19. https://doi.org/10.1038/nn.4447

    Schmid LC, Mittag M, Poll S, Steffen J, Wagner J, Geis HR, Schwarz I, Schmidt B, Schwarz MK, Remy S, Fuhrmann M. 2016. Dysfunction of Somatostatin-Positive Interneurons Associated with Memory Deficits in an Alzheimer's Disease Model. Neuron. 92(1):114-125. https://doi.org/10.1016/j.neuron.2016.08.034

    Fuhrmann F, Justus D, Sosulina L, Kaneko H, Beutel T, Friedrichs D, Schoch S, Schwarz MK, Fuhrmann M, Remy S. 2015. Locomotion, Theta Oscillations, and the Speed-Correlated Firing of Hippocampal Neurons Are Controlled by a Medial Septal Glutamatergic Circuit. Neuron. 86(5):1253-1264. https://doi.org/10.1016/j.neuron.2015.05.001

    Šišková Z, Justus D, Kaneko H, Friedrichs D, Henneberg N, Beutel T, Pitsch J, Schoch S, Becker A, vonderKammer H, Remy S. 2014. Dendritic structural degeneration is functionally linked to cellular hyperexcitability in a mouse model of alzheimer's disease. Neuron. 84(5):1023-1033. https://doi.org/10.1016/j.neuron.2014.10.024

    Müller C, Beck H, Coulter D, Remy S. 2012. Inhibitory Control of Linear and Supralinear Dendritic Excitation in CA1 Pyramidal Neurons. Neuron. 75(5):851-864. https://doi.org/10.1016/j.neuron.2012.06.025

    Krueppel R, Remy S, Beck H. 2011. Dendritic integration in hippocampal dentate granule cells. Neuron. 71(3):512-528. https://doi.org/10.1016/j.neuron.2011.05.043

    Park JY, Remy S, Varela J, Cooper DC, Chung S, Kang HW, Lee JH, Spruston N. 2010. A post-burst afterdepolarization is mediated by group I metabotropic glutamate receptor-dependent upregulation of Cav2.3 R-type calcium channels in CA1 pyramidal neurons. PLoS Biology. 8(11):e1000534. https://doi.org/10.1371/journal.pbio.1000534

    Remy S, Csicsvari J, Beck H. 2009. Activity-Dependent Control of Neuronal Output by Local and Global Dendritic Spike Attenuation. Neuron. 61(6):906-916. https://doi.org/10.1016/j.neuron.2009.01.032

    Remy S, Spruston N. 2007. Dendritic spikes induce single-burst long-term potentiation. Proceedings of the National Academy of Sciences of the United States of America. 104(43):17192-17197. https://doi.org/10.1073/pnas.0707919104

     

    All publications of the department

    2020

    Bertan F, Wischhof L, Sosulina L, Mittag M, Dalügge D, Fornarelli A, Gardoni F, Marcello E, Di Luca M, Fuhrmann M, Remy S, Bano D, Nicotera P. 2020. Loss of Ryanodine Receptor 2 impairs neuronal activity-dependent remodeling of dendritic spines and triggers compensatory neuronal hyperexcitability. Cell Death and Differentiation. https://doi.org/10.1038/s41418-020-0584-2

    Sosulina L, Mittag M, Geis H-R, Hoffmann K, Klyubin I, Qi Y, Steffen J, Friedrichs D,  Henneberg N,  Fuhrmann F, Justus D, Keppler K, Cuello A, Rowan M J, Fuhrmann M, Remy S. 2020. Hippocampal hyperactivity in a rat model of Alzheimer’s disease. BioRxiv. https://doi.org/10.1101/2020.06.09.141598

    Luxem K, Fuhrmann F, Kürsch J, Remy S*, Bauer P*. 2020. Identifying Behavioral Structure from Deep Variational Embeddings of Animal Motion. BioRxiv. https://doi.org/10.1101/2020.05.14.095430 * shared senior authorship

     

    2019

    Schwarz MK, Remy S. 2019. Rabies virus-mediated connectivity tracing from single neurons. Journal of Neuroscience Methods. 325:108365. https://doi.org/10.1016/j.jneumeth.2019.108365

    Lindén J, Bauer P, Engblom S, Jonsson B. 2019. Exposing Inter-process Information for Efficient PDES of Spatial Stochastic Systems on Multicores. ACM Transactions on Modeling and Computer Simulation. 29(2):Article 11. https://doi.org/10.1145/3301500

    Widgren S, Bauer P, Eriksson R, Engblom S. 2019. Siminf: An R package for data-driven stochastic disease spread simulations. Journal of Statistical Software. 91(12):1-42. https://doi.org/10.18637/jss.v091.i12

    Luxem K, Fuhrmann F, Remy S, Bauer P. 2019. Hierarchical network analysis of behavior and neuronal population activity. In: 2019 Conference on Cognitive Computational Neuroscience. Berlin, Germany: Cognitive Computational Neuroscience; 2019. https://doi.org/10.32470/CCN.2019.1261-0

     

    2018

    Bauer P, Engblom S, Mikulovic S, Senek A. 2018. Multiscale modelling via split-step methods in neural firing. Mathematical and Computer Modelling of Dynamical Systems. 24(4):409-425. https://doi.org/10.1080/13873954.2018.1488740

    Dalügge D, Remy S. 2018. Human Cortical Dendrites: Stretched to Perform Better?. Cell. 175(3):635-637. https://doi.org/10.1016/j.cell.2018.09.052

    Giovannetti E, Poll S, Justus D, Kaneko H, Fuhrmann F, Steffen J, Remy S, Fuhrmann M. 2018. Restoring memory by optogenetic synchronization of hippocampal oscillations in an Alzheimer’s disease mouse model. BioRXiv (preprint). https://doi.org/10.1101/363820

    Lindén J, Bauer P, Engblom S, Jonsson B. 2018. Fine-grained local dynamic load balancing in PDES. In SIGSIM-PADS 2018 - Proceedings of the 2018 ACM SIGSIM Conference on Principles of Advanced Discrete Simulation. Association for Computing Machinery, Inc. pp. 201-212. (SIGSIM-PADS 2018 - Proceedings of the 2018 ACM SIGSIM Conference on Principles of Advanced Discrete Simulation). https://doi.org/10.1145/3200921.3200928

    Mikulovic S, Restrepo CE, Siwani S, Bauer P, Pupe S, Tort ABL, Kullander K, Leão RN. 2018. Ventral hippocampal OLM cells control type 2 theta oscillations and response to predator odor. Nature Communications. 9(1):Article 3638. https://doi.org/10.1038/s41467-018-05907-w

    Musial TF, Molina-Campos E, Bean LA, Ybarra N, Borenstein R, Russo ML, Buss EW, Justus D, Neuman KM, Ayala GD, Mullen SA, Voskobiynyk Y, Tulisiak CT, Fels JA, Corbett NJ, Carballo G, Kennedy CD, Popovic J, Ramos-Franco J, Fill M, Pergande MR, Borgia JA, Corbett GT, Pahan K, Han Y, Chetkovich DM, Vassar RJ, Byrne RW, Matthew Oh M, Stoub TR, Remy S, Disterhoft JF, Nicholson DA. 2018. Store depletion-induced h-channel plasticity rescues a channelopathy linked to Alzheimer's disease. Neurobiology of Learning and Memory. 154:141-157. https://doi.org/10.1016/j.nlm.2018.06.004

    Müller C, Geis HR, Remy S. 2018. Visually Guided Single-Cell Recordings in the Hippocampus of Awake Mice. Manahan-Vaughan D, editor. In Handbook of in Vivo Neural Plasticity Techniques. Elsevier B.V. pp. 123-134. (Handbook of Behavioral Neuroscience). https://doi.org/10.1016/B978-0-12-812028-6.00006-9

    Müller C, Remy S. 2018. Septo–hippocampal interaction. Cell and Tissue Research. 373(3):565-575. https://doi.org/10.1007/s00441-017-2745-2

     

    2017

    Justus D, Dalügge D, Bothe S, Fuhrmann F, Hannes C, Kaneko H, Friedrichs D, Sosulina L, Schwarz I, Elliott DA, Schoch S, Bradke F, Schwarz MK, Remy S. 2017. Glutamatergic synaptic integration of locomotion speed via septoentorhinal projections. Nature Neuroscience. 20(1):16-19. https://doi.org/10.1038/nn.4447

    Lindén J, Bauer P, Engblom S, Jonsson B. 2017. Exposing inter-process information for efficient parallel discrete event simulation of spatial stochastic systems. In SIGSIM-PADS 2017 - Proceedings of the 2017 ACM SIGSIM Conference on Principles of Advanced Discrete Simulation. Association for Computing Machinery, Inc. pp. 53-64. (SIGSIM-PADS 2017 - Proceedings of the 2017 ACM SIGSIM Conference on Principles of Advanced Discrete Simulation). https://doi.org/10.1145/3064911.3064916

    Remy S, Poirazi P, Papoutsi A. 2017. Introduction to the Computational Neuroscience Special Section. European Journal of Neuroscience. 45(8):998-999. https://doi.org/10.1111/ejn.13562

     

    2016

    Bauer P, Engblom S, Widgren S. 2016. Fast event-based epidemiological simulations on national scales. International Journal of High Performance Computing Applications. 30(4):438-453. https://doi.org/10.1177/1094342016635723

    Müller C, Remy S. 2016. Slowly Building Excitement. Cell. 165(7):1568-1569. https://doi.org/10.1016/j.cell.2016.06.005

    Schmid LC, Mittag M, Poll S, Steffen J, Wagner J, Geis HR, Schwarz I, Schmidt B, Schwarz MK, Remy S, Fuhrmann M. 2016. Dysfunction of Somatostatin-Positive Interneurons Associated with Memory Deficits in an Alzheimer's Disease Model. Neuron. 92(1):114-125. https://doi.org/10.1016/j.neuron.2016.08.034

    Widgren S, Engblom S, Bauer P, Frössling J, Emanuelson U, Lindberg A. 2016. Data-driven network modelling of disease transmission using complete population movement data: spread of VTEC O157 in Swedish cattle. Veterinary Research. 47(1):1-17. https://doi.org/10.1186/s13567-016-0366-5

     

    2015

    Bauer P, Engblom S. 2015. Sensitivity estimation and inverse problems in spatial stochastic models of chemical kinetics. Lecture Notes in Computational Science and Engineering. 103:519-527. https://doi.org/10.1007/978-3-319-10705-9__51

    Bauer P, Lindén J, Engblom S, Jonsson B. 2015. Efficient inter-process synchronization for parallel discrete event simulation on multicores. In SIGSIM-PADS 2015 - Proceedings of the 3rd ACM Conference on SIGSIM-Principles of Advanced Discrete Simulation. Association for Computing Machinery, Inc. pp. 183-194. (SIGSIM-PADS 2015 - Proceedings of the 3rd ACM Conference on SIGSIM-Principles of Advanced Discrete Simulation). https://doi.org/10.1145/2769458.2769476

    Fuhrmann F, Justus D, Sosulina L, Kaneko H, Beutel T, Friedrichs D, Schoch S, Schwarz MK, Fuhrmann M, Remy S. 2015. Locomotion, Theta Oscillations, and the Speed-Correlated Firing of Hippocampal Neurons Are Controlled by a Medial Septal Glutamatergic Circuit. Neuron. 86(5):1253-1264. https://doi.org/10.1016/j.neuron.2015.05.001

    Milias-Argeitis A, Engblom S, Bauer P, Khammash M. 2015. Stochastic focusing coupled with negative feedback enables robust regulation in biochemical reaction networks. Journal of the Royal Society Interface. 12(113):Article 20150831. https://doi.org/10.1098/rsif.2015.0831

    Patra K, Lyons DJ, Bauer P, Hilscher MM, Sharma S, Leão RN, Kullander K. 2015. A role for solute carrier family 10 member 4, or vesicular aminergic-associated transporter, in structural remodelling and transmitter release at the mouse neuromuscular junction. European Journal of Neuroscience. 41(3):316-327. https://doi.org/10.1111/ejn.12790

    Wagner J, Krauss S, Shi S, Ryazanov S, Steffen J, Miklitz C, Leonov A, Kleinknecht A, Göricke B, Weishaupt JH, Weckbecker D, Reiner AM, Zinth W, Levin J, Ehninger D, Remy S, Kretzschmar HA, Griesinger C, Giese A, Fuhrmann M. 2015. Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies. Acta Neuropathologica. 130(5):619-631. https://doi.org/10.1007/s00401-015-1483-3

     

    2014

    Müller C, Remy S. 2014. Dendritic inhibition mediated by O-LM and bistratified interneurons in the hippocampus. Frontiers in Synaptic Neuroscience. 6(SEP):23. https://doi.org/10.3389/fnsyn.2014.00023

    Pothmann L, Müller C, Averkin RG, Bellistri E, Miklitz C, Uebachs M, Remy S, de la Prida LM, Beck H. 2014. Function of inhibitory micronetworks is spared by Na+ channel-acting anticonvulsant drugs. Journal of Neuroscience. 34(29):9720-9735. https://doi.org/10.1523/JNEUROSCI.2395-13.2014

    Qi Y, Klyubin I, Harney SC, Hu NW, Cullen WK, Grant MK, Steffen J, Wilson EN, Do Carmo S, Remy S, Fuhrmann M, Ashe KH, Cuello AC, Rowan MJ. 2014. Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aß-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: Rapid reversal by anti-Aß agents. Acta neuropathologica communications. 2(1):175. https://doi.org/10.1186/s40478-014-0175-x

    Šišková Z, Justus D, Kaneko H, Friedrichs D, Henneberg N, Beutel T, Pitsch J, Schoch S, Becker A, vonderKammer H, Remy S. 2014. Dendritic structural degeneration is functionally linked to cellular hyperexcitability in a mouse model of alzheimer's disease. Neuron. 84(5):1023-1033. https://doi.org/10.1016/j.neuron.2014.10.024

     

    2013

    Müller C, Remy S. 2013. Fast micro-iontophoresis of glutamate and GABA: a useful tool to investigate synaptic integration. Journal of visualized experiments: JoVE. (77). https://doi.org/10.3791/50701

    2012

    Müller C, Beck H, Coulter D, Remy S. 2012. Inhibitory Control of Linear and Supralinear Dendritic Excitation in CA1 Pyramidal Neurons. Neuron. 75(5):851-864. https://doi.org/10.1016/j.neuron.2012.06.025

    2011

    Krueppel R, Remy S, Beck H. 2011. Dendritic integration in hippocampal dentate granule cells. Neuron. 71(3):512-528. https://doi.org/10.1016/j.neuron.2011.05.043

    Chen S, Su H, Yue C, Remy S, Royeck M, Sochivko D, Opitz T, Beck H, Yaari Y. 2011. An increase in persistent sodium current contributes to intrinsic neuronal bursting after status epilepticus. Journal of Neurophysiology. 105(1):117-129. https://doi.org/10.1152/jn.00184.2010

    2010

    Park JY, Remy S, Varela J, Cooper DC, Chung S, Kang HW, Lee JH, Spruston N. 2010. A post-burst afterdepolarization is mediated by group I metabotropic glutamate receptor-dependent upregulation of Cav2.3 R-type calcium channels in CA1 pyramidal neurons. PLoS Biology. 8(11):e1000534. https://doi.org/10.1371/journal.pbio.1000534

    Remy S, Beck H, Yaari Y. 2010. Plasticity of voltage-gated ion channels in pyramidal cell dendrites. Current Opinion in Neurobiology. 20(4):503-509. https://doi.org/10.1016/j.conb.2010.06.006

    2009

    Remy S, Csicsvari J, Beck H. 2009. Activity-Dependent Control of Neuronal Output by Local and Global Dendritic Spike Attenuation. Neuron. 61(6):906-916. https://doi.org/10.1016/j.neuron.2009.01.032

    2008

    Royeck M, Horstmann MT, Remy S, Reitze M, Yaari Y, Beck H. 2008. Role of axonal NaV1.6 sodium channels in action potential initiation of CA1 pyramidal neurons. Journal of Neurophysiology. 100(4):2361-2380. https://doi.org/10.1152/jn.90332.2008

    2007

    Remy S, Spruston N. 2007. Dendritic spikes induce single-burst long-term potentiation. Proceedings of the National Academy of Sciences of the United States of America. 104(43):17192-17197. https://doi.org/10.1073/pnas.0707919104

    2006

    Remy S, Beck H. 2006. Molecular and cellular mechanisms of pharmacoresistance in epilepsy. Brain. 129(Pt 1):18-35. https://doi.org/10.1093/brain/awh682

    Heinemann U, Kann O, Remy S, Beck H. 2006. Novel mechanisms underlying drug resistance in temporal lobe epilepsy. Advances in neurology. 97:85-95.

    2005

    Yue C, Remy S, Su H, Beck H, Yaari Y. 2005. Proximal persistent Na+ channels drive spike afterdepolarizations and associated bursting in adult CA1 pyramidal cells. Journal of Neuroscience. 25(42):9704-9720. https://doi.org/10.1523/JNEUROSCI.1621-05.2005

    2004

    Remy C, Remy S, Beck H, Swandulla D, Hans M. 2004. Modulation of voltage-dependent sodium channels by the δ-agonist SNC80 in acutely isolated rat hippocampal neurons. Neuropharmacology. 47(7):1102-1112. https://doi.org/10.1016/j.neuropharm.2004.06.034

    2003

    Ellerkmann RK, Remy S, Chen J, Sochivko D, Elger CE, Urban BW, Becker A, Beck H. 2003. Molecular and functional changes in voltage-dependent Na+ channels following pilocarpine-induced status epilepticus in rat dentate granule cells. Neuroscience. 119(2):323-333. https://doi.org/10.1016/S0306-4522(03)00168-4

    Remy S, Urban BW, Elger CE, Beck H. 2003. Anticonvulsant pharmacology of voltage-gated Na+ channels in hippocampal neurons of control and chronically epileptic rats. European Journal of Neuroscience. 17(12):2648-2658. https://doi.org/10.1046/j.1460-9568.2003.02710.x

    Remy S, Gabriel S, Urban BW, Dietrich D, Lehmann TN, Elger CE, Heinemann U, Beck H. 2003. A novel mechanism underlying drug resistance in chronic epilepsy. Annals of Neurology. 53(4):469-479. https://doi.org/10.1002/ana.10473

     

     

     

  • Methods

    Methods

  • Third Party Funds
  • Open Science

    Open Science

    public data of the department

    • The data set includes detailed electrophysiological characterizations of cell types in the medial entorhinal cord (layer 2/3).
    • This GitHub repository contains the research code of the VAME framework as well as documentation and exemplary data: Variational Animal Motion Embedding (VAME)
  • Follow us

    Follow us

    Follow us @Twitter: SR_neurostar

     

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