Research Group Neuromodulatory Networks

Psychiatric disorders such as severe depression or attention disorders have long been associated with an altered level of neuromodulators in certain brain areas. Our team is interested in understanding changes in neuromodulators such as dopamine, serotonin or norepinephrine in the brain. However, altered levels of neuromodulation are not only related to many psychiatric disorders, but also influence cognitive performance in everyday life: fatigue, agitation and sadness are all correlated with activity patterns of neurons that release such neuromodulators.

While specific behaviour patterns have been associated with certain neuromodulators and the activation of certain receptors and their downstream signalling pathways have also been associated with these neuromodulators, it is still unknown today how neuromodulatory neurons function, how they adapt and how their global projections still permit surface specificity.

  • Head

    Head

    Matthias Prigge studied biochemistry at the Freie Universität Berlin and philosophy at the Humboldt-Universität Berlin. He then received his doctorate in experimental biophysics from the Humboldt University in Peter Hegemann's laboratory where he was fascinated by microbial rhodopsins. Today, these proteins are commonly used to manipulate neuronal activity of neurons in animal behavior with light.


    Prigge then worked as a postdoc with Ofer Yizhar at the Weizmann Institute in Israel. There he was particularly interested in how neuromodulatory systems adapt to environmental stimuli.

    In his own lab, he wants to use his different skills to develop new optical tools and technologies for the analysis of neuromodulatory networks.

  • Members

    Members

    Head  
    Dr. Matthias Prigge+49-391-6263-92211matthias.prigge@lin-magdeburg.de
    Sekretary  
    Beate Traoré+49-391-6263-95481beate.traore@lin-magdeburg.de
    PhD students  
    Ipek Akol+49-391-6263-94611ipek.akol@lin-magdeburg.de
    Damaris Holder+49-391-6263-94611damaris.holder@lin-magdeburg.de
    Technical staff member  
    Stefanie Hillert+49-391-6263-94611stefanie.hillert@lin-magdeburg.de
  • Projects

    Projects

    Please find further information about our research here: http://teamprigge.de/

     

  • Current Third Party Funds

    Current Third Party Funds

  • Publications

    Publications

    2017

    Wiegert JS, Mahn M, Prigge M, Printz Y, Yizhar O. 2017. Silencing Neurons: Tools, Applications, and Experimental Constraints. Neuron. 95(3):504-529. Available from: 10.1016/j.neuron.2017.06.050

    Tsunoda SP, Prigge M, Abe-Yoshizumi R, Inoue K, Kozaki Y, Ishizuka T, Yawo H, Yizhar O, Kandori H. 2017. Functional characterization of sodium-pumping rhodopsins with different pumping properties. PLoS ONE. 12(7). Available from: 10.1371/journal.pone.0179232

    Tkatch T, Greotti E, Baranauskas G, Pendin D, Roy S, Nita LI, Wettmarshausen J, Prigge M, Yizhar O, Shirihai OS, Fishman D, Hershfinkel M, Fleidervish IA, Perocchi F, Pozzan T, Sekler I. 2017. Optogenetic control of mitochondrial metabolism & Ca2+ signaling by mitochondria-Targeted opsins. Proceedings of the National Academy of Sciences of the United States of America. 114(26):E5167-E5176. Available from: 10.1073/pnas.1703623114

    Klavir O, Prigge M, Sarel A, Paz R, Yizhar O. 2017. Manipulating fear associations via optogenetic modulation of amygdala inputs to prefrontal cortex. Nature Neuroscience. 20(6):836-844. Available from: 10.1038/nn.4523

     

    2016

    Mahn M, Prigge M, Ron S, Levy R, Yizhar O. 2016. Biophysical constraints of optogenetic inhibition at presynaptic terminals. Nature Neuroscience. 19(4):554-556. Available from: 10.1038/nn.4266

    Wietek J, Prigge M. 2016. Enhancing channelrhodopsins: An Overview. In Methods in Molecular Biology. Humana Press Inc. pp. 141-165. (Methods in Molecular Biology). Available from: 10.1007/978-1-4939-3512-3_10

     

    2015

    Scott N, Prigge M, Yizhar O, Kimchi T. 2015. A sexually dimorphic hypothalamic circuit controls maternal care and oxytocin secretion. Nature. 525(7570):519-522. Available from: 10.1038/nature15378

     

    2014

    Pashaie R, Anikeeva P, Lee JH, Prakash R, Yizhar O, Prigge M, Chander D, Richner TJ, Williams J. 2014. Optogenetic brain interfaces. IEEE Reviews in Biomedical Engineering. 7:3-30. Available from: 10.1109/RBME.2013.2294796

     

    2013

    Akerboom J, Calderón NC, Tian L, Wabnig S, Prigge M, Tolö J, Gordus A, Orger MB, Severi KE, Macklin JJ, Patel R, Pulver SR, Wardill TJ, Fischer E, Schüler C, Chen TW, Sarkisyan KS, Marvin JS, Bargmann CI, Kim DS, Kügler S, Lagnado L, Hegemann P, Gottschalk A, Schreiter ER, Looger LL. 2013. Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics. Frontiers in Molecular Neuroscience. (FEB). Available from: 10.3389/fnmol.2013.00002

     

    2012

    Erbguth K, Prigge M, Schneider F, Hegemann P, Gottschalk A. 2012. Bimodal Activation of Different Neuron Classes with the Spectrally Red-Shifted Channelrhodopsin Chimera C1V1 in Caenorhabditis elegans. PLoS ONE. 7(10). Available from: 10.1371/journal.pone.0046827

    Prigge M, Schneider F, Tsunoda SP, Shilyansky C, Wietek J, Deisseroth K, Hegemann P. 2012. Color-tuned channelrhodopsins for multiwavelength optogenetics. Journal of Biological Chemistry. 287(38):31804-31812. Available from: 10.1074/jbc.M112.391185

     

    2011

    Zhang F, Vierock J, Yizhar O, Fenno LE, Tsunoda S, Kianianmomeni A, Prigge M, Berndt A, Cushman J, Polle J, Magnuson J, Hegemann P, Deisseroth K. 2011. The microbial opsin family of optogenetic tools. Cell. 147(7):1446-1457. Available from: 10.1016/j.cell.2011.12.004

    Yizhar O, Fenno LE, Prigge M, Schneider F, Davidson TJ, Ogshea DJ, Sohal VS, Goshen I, Finkelstein J, Paz JT, Stehfest K, Fudim R, Ramakrishnan C, Huguenard JR, Hegemann P, Deisseroth K. 2011. Neocortical excitation/inhibition balance in information processing and social dysfunction. Nature. 477(7363):171-178. Available from: 10.1038/nature10360

     

    2010

    Berndt A, Prigge M, Gradmann D, Hegemann P. 2010. Two open states with progressive proton selectivities in the branched channelrhodopsin-2 photocycle. Biophysical Journal. 98(5):753-761. Available from: 10.1016/j.bpj.2009.10.052

    Prigge M, Rösler A, Hegemann P. 2010. Fast, repetitive light-activation of CaV3.2 using channelrhodopsin 2. Channels. 4(3). Available from: 10.4161/chan.4.3.11888

  • Methods

    Methods

    • Patch-Clamp in acute slices and cell culture
    • In-vivo electrophsiology
    • Mouse behavior
    • Immunostaining + Clarity
    • Photoreceptor design and Optogenetics

     

  • Social Media

    Social Media

    Matthias Prigge shares news on this Twitter account: https://twitter.com/_MaPr_

     

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