LIN Staff

Prof. Dr. Constanze Seidenbecher

Head of Working Group

Staff Unit

Leibniz Institute for Neurobiology
Brenneckestr. 6
39118 Magdeburg
Phone: +49 391 6263 92401
ORCID: 0000-0002-7433-2716

  • Research interests

    Research interests

    We want to unravel how the extracellular matrix of the brain contributes to the enormous capability and plasticity of this organ. 

    The brain extracellular matrix, which amounts to 20-25% of the tissue, is formed by neurons and glial cells and consists of large carbohydrate polymers like hyaluronic acid, proteoglycans like Brevican or Neurocan, and a variety of glycoproteins. It changes its structure and composition during brain development of animals and humans, but also upon brain damage, neurological or psychiatric disorders and during natural ageing. 

    It is our goal to understand how nerve cell activity, e.g. during learning or remembering, and matrix integrity are linked. Thus ,we study on one hand how experimental matrix changes, e.g. after enzymatic degradation or in proteoglycan mutant mice, affects neuronal activity and cognitive processes in animals. On the other hand, we  search for naturally occuring matrix changes induced or modulated by neural activity. 

    We are particularly focused on the role of neuromodulators like dopamine in matrix reconstruction and we search for matrix changes upon healthy ageing and epilepsy. 

    In human subjects we look for single nucleotide polymorphisms in matrix-encoding genes and search for correlations with cognitive capabilities and flexibility in the allele carriers. 

  • Curriculum vitae

    Curriculum vitae

    Constanze Seidenbecher studied Biochemistry at Martin Luther University Halle from 1983 to 1988 and obtained her Ph.D in molecular Neuroscience at the Otto von Guericke University Magdeburg in 1996. She finished her habilitation in 2005 and obtained the Venia legendi for Biochemistry at the Medical Faculty of the Otto von Guericke University, where she was appointed as adjunct professor in 2015. She gives lectures in Neurobiochemistry for medical students and teaches also in the international study program Integrative Neuroscience.

    Constanze Seidenbecher is head of the work group "Synapse - Brain - Cognition" together with Björn Schott. 

    Since 2004 she is also head of the Science Management and Public Relations group at LIN and represents the Leibniz Association in the support association for "DasGehirn.Info" since 2022.

    Within the Center for Behavioral Brain Sciences (CBBS) Magdeburg she supports the Neuro-site Magdeburg since its foundation in 2007 and is member of the CBBS Board of directors since 2017. Furthermore, she is steering committee member of the Collaborative Research Center "Neural Resources of Cognition", of the SynAGE graduate school and of the Jena - Magdeburg - Halle site of the DZPG "CIRC". 

    As chair of the Advanced School Subcommittee of the International Society for Neurochemistry she organized international Summer schools for doctoral students and postdocs in Greece, Mexico, Australia, and France between 2009 and 2017, and since 2020 she is ISN council member. 

    Since 2015 she acts as Handling Editor for Journal of Neurochemistry and Review Editor for Frontiers in Molecular Neuroscience.

    Moreover, she is a mentor for young scientists. 

  • Publications


    Hußler W, Höhn L, Stolz C, Vielhaber S, Garz C, Schmitt FC, Gundelfinger ED, Schreiber S, Seidenbecher CI. 2022. Brevican and Neurocan Cleavage Products in the Cerebrospinal Fluid - Differential Occurrence in ALS, Epilepsy and Small Vessel Disease. Frontiers in Cellular Neuroscience. 16:Article 838432.

    Richter A, Soch J, Kizilirmak JM, Fischer L, Schütze H, Assmann A, Behnisch G, Feldhoff H, Knopf L, Raschick M, Schult A, Seidenbecher CI, Yakupov R, Düzel E, Schott BH. 2022. Summary statistics of memory-related fMRI activity reflect dissociable neuropsychological and anatomical signatures of neurocognitive aging. bioRxiv.

    Malci A, Sandoval R, Gundelfinger ED, Naumann M, Seidenbecher C, Herrera-Molina R. 2022. Ca2+ signaling in postsynaptic neurons: neuroplastin-65 regulates the interplay between plasma membrane Ca2+ ATPases and ionotropic glutamate receptors. Cell calcium. 106:Article 102623.

    Richter A, de Boer L, Guitart-Masip M, Behnisch G, Seidenbecher CI, Schott BH. 2021. Motivational learning biases are differentially modulated by genetic determinants of striatal and prefrontal dopamine function. Journal of Neural Transmission. 128(11):1705-1720.

    Soch J, Richter A, Schütze H, Kizilirmak JM, Assmann A, Behnisch G, Feldhoff H, Fischer L, Heil J, Knopf L, Merkel C, Raschick M, Schietke C-J, Schult A, Seidenbecher CI, Yakupov R, Ziegler G, Wiltfang J, Düzel E, Schott BH. 2021. A comprehensive score reflecting memory-related fMRI activations and deactivations as potential biomarker for neurocognitive aging. Human Brain Mapping. 42(14):4478-4496.

    Dityatev A, Seidenbecher C, Morawski M. 2021. Brain extracellular matrix: An upcoming target in neurological and psychiatric disorders. European Journal of Neuroscience. 53(12):3807-3810.

    Assmann A, Richter A, Schütze H, Soch J, Barman A, Behnisch G, Knopf L, Raschick M, Schult A, Wüstenberg T, Behr J, Düzel E, Seidenbecher CI, Schott BH. 2021. Neurocan genome-wide psychiatric risk variant affects explicit memory performance and hippocampal function in healthy humans. European Journal of Neuroscience. 53(12):3942-3959.

    Martens L, Herrmann L, Colic L, Li M, Richter A, Behnisch G, Stork O, Seidenbecher C, Schott BH, Walter M. 2021. Met carriers of the BDNF Val66Met polymorphism show reduced Glx/NAA in the pregenual ACC in two independent cohorts. Scientific Reports. 11(1):Article 6742.

    Vemula SK, Malci A, Junge L, Lehmann AC, Rama R, Hradsky J, Matute RA, Weber A, Prigge M, Naumann M, Kreutz MR, Seidenbecher CI, Gundelfinger ED, Herrera-Molina R. 2020. The Interaction of TRAF6 With Neuroplastin Promotes Spinogenesis During Early Neuronal Development. Frontiers in Cell and Developmental Biology. 8:Article 579513.

    Betts MJ, Richter A, de Boer L, Tegelbeckers J, Perosa V, Baumann V, Chowdhury R, Dolan RJ, Seidenbecher C, Schott BH, Düzel E, Guitart-Masip M, Krauel K. 2020. Learning in anticipation of reward and punishment: perspectives across the human lifespan. Neurobiology of Aging. 96:49-57.

    Mitlöhner J, Kaushik R, Niekisch H, Blondiaux A, Gee CE, Happel MFK, Gundelfinger E, Dityatev A, Frischknecht R, Seidenbecher C. 2020. Dopamine Receptor Activation Modulates the Integrity of the Perisynaptic Extracellular Matrix at Excitatory Synapses. Cells. 9(2):Article 260.

    Bordone MP, Salman MM, Titus HE, Amini E, Andersen JV, Chakraborti B, Diuba AV, Dubouskaya TG, Ehrke E, Freitas AE, Freitas GB, Gonçalves RA, Gupta D, Gupta R, Ha SR, Hemming IA, Jaggar M, Jakobsen E, Kumari P, Lakkappa N, L Marsh AP, Mitlöhner J, Ogawa Y, Paidi RK, Ribeiro FC, Salamian A, Saleem S, Sharma S, Silva JM, Singh S, Sulakhiya K, Tefera TW, Vafadari B, Yadav A, Yamazaki R, Seidenbecher CI. 2019. The energetic brain - A review from students to students. Journal of Neurochemistry. 151(2):139-165.

    Schott BH, Wüstenberg T, Lücke E, Pohl IM, Richter A, Seidenbecher CI, Pollmann S, Kizilirmak JM, Richardson-Klavehn A. 2019. Gradual acquisition of visuospatial associative memory representations via the dorsal precuneus. Human Brain Mapping. 40(5):1554-1570.

    Colic L, Li M, Demenescu LR, Li S, Müller I, Richter A, Behnisch G, Seidenbecher CI, Speck O, Schott BH, Stork O, Walter M. 2018. GAD65 promoter polymorphism rs2236418 modulates harm avoidance in women via inhibition/excitation balance in the rostral ACC. Journal of Neuroscience. 38(22):5067-5077.

    Korthals M, Langnaese K, Smalla KH, Kähne T, Herrera-Molina R, Handschuh J, Lehmann AC, Mamula D, Naumann M, Seidenbecher C, Zuschratter W, Tedford K, Gundelfinger ED, Montag D, Fischer KD, Thomas U. 2017. A complex of Neuroplastin and Plasma Membrane Ca2+ ATPase controls T cell activation. Scientific Reports. 7(1):Article 8358.

    Richter A, Barman A, Wüstenberg T, Soch J, Schanze D, Deibele A, Behnisch G, Assmann A, Klein M, Zenker M, Seidenbecher C, Schott BH. 2017. Behavioral and neural manifestations of reward memory in carriers of low-expressing versus high-expressing genetic variants of the dopamine D2 receptor. Frontiers in Psychology. 8(MAY):Article 654.

    Lepeta K, Lourenco MV, Schweitzer BC, Martino Adami PV, Banerjee P, Catuara-Solarz S, de La Fuente Revenga M, Guillem AM, Haidar M, Ijomone OM, Nadorp B, Qi L, Perera ND, Refsgaard LK, Reid KM, Sabbar M, Sahoo A, Schaefer N, Sheean RK, Suska A, Verma R, Vicidomini C, Wright D, Zhang XD, Seidenbecher C. 2016. Synaptopathies: synaptic dysfunction in neurological disorders – A review from students to students. Journal of Neurochemistry. 138(6):785-805.

    Kähne T, Richter S, Kolodziej A, Smalla KH, Pielot R, Engler A, Ohl FW, Dieterich DC, Seidenbecher C, Tischmeyer W, Naumann M, Gundelfinger ED. 2016. Proteome rearrangements after auditory learning: high-resolution profiling of synapse-enriched protein fractions from mouse brain. Journal of Neurochemistry. 138(1):124-138.

    Lubbers BR, Matos MR, Horn A, Visser E, Van Der Loo RC, Gouwenberg Y, Meerhoff GF, Frischknecht R, Seidenbecher CI, Smit AB, Spijker S, Van Den Oever MC. 2016. The Extracellular Matrix Protein Brevican Limits Time-Dependent Enhancement of Cocaine Conditioned Place Preference. Neuropsychopharmacology. 41(7):1907-1916.

    Barman A, Richter S, Soch J, Deibele A, Richter A, Assmann A, Wüstenberg T, Walter H, Seidenbecher CI, Schott BH. 2015. Gender-specific modulation of neural mechanisms underlying social reward processing by Autism Quotient. Social Cognitive and Affective Neuroscience. 10(11):1537-1547.

    Blosa M, Sonntag M, Jäger C, Weigel S, Seeger J, Frischknecht R, Seidenbecher CI, Matthews RT, Arendt T, Rübsamen R, Morawski M. 2015. The extracellular matrix molecule brevican is an integral component of the machinery mediating fast synaptic transmission at the calyx of Held. Journal of Physiology. 593(19):4341-4360.

    Valenzuela Macaya JC, Heise C, Franken G, Singh J, Schweitzer B, Seidenbecher CI, Frischknecht R. 2014. Hyaluronan-based extracellular matrix under conditions of homeostatic plasticity. Philosophical Transactions of the Royal Society B: Biological Sciences. 369(1654).

    Beesley PW, Herrera-Molina R, Smalla KH, Seidenbecher C. 2014. The Neuroplastin adhesion molecules: key regulators of neuronal plasticity and synaptic function. Journal of Neurochemistry. 131(3):268-283.

    Richter A, Guitart-Masip M, Barman A, Libeau C, Behnisch G, Czerney S, Schanze D, Assmann A, Klein M, Düzel E, Zenker M, Seidenbecher CI, Schott BH. 2014. Valenced action/inhibition learning in humans is modulated by a genetic variant linked to dopamine D2 receptor expression. Frontiers in Systems Neuroscience. 8(AUG):Article 140.

    Barman A, Assmann A, Richter S, Soch J, Schütze H, Wüstenberg T, Deibele A, Klein M, Richter A, Behnisch G, Düzel E, Zenker M, Seidenbecher CI, Schott BH. 2014. Genetic variation of the RASGRF1 regulatory region affects human hippocampus-dependent memory. Frontiers in Human Neuroscience. 8:Article 260.

    Herrera Molina R, Sarto-Jackson I, Montenegro-Venegas C, Heine M, Smalla KH, Seidenbecher CI, Beesley PW, Gundelfinger ED, Montag D. 2014. Structure of excitatory synapses and GABAA receptor localization at inhibitory synapses are regulated by neuroplastin-65. Journal of Biological Chemistry. 289(13):8973-8988.

    Schott BH, Assmann A, Schmierer P, Soch J, Erk S, Garbusow M, Mohnke S, Pöhland L, Romanczuk-Seiferth N, Barman A, Wüstenberg T, Haddad L, Grimm O, Witt S, Richter S, Klein M, Schütze H, Mühleisen TW, Cichon S, Rietschel M, Noethen MM, Tost H, Gundelfinger ED, Düzel E, Heinz A, Meyer-Lindenberg A, Seidenbecher CI, Walter H. 2014. Epistatic interaction of genetic depression risk variants in the human subgenual cingulate cortex during memory encoding. Translational Psychiatry. 4(3):e372.

    Mawrin C, Seidenbecher C. 2014. Glioma and Extracellular Matrix. Sedo A, Mentlein R, editors. In Glioma Cell Biology. Vienna: Springer.

    Frischknecht R, Chang KJ, Rasband MN, Seidenbecher CI. 2014. Neural ECM molecules in axonal and synaptic homeostatic plasticity. Progress in Brain Research. 214:81-100.

    Bernstein HG, Dobrowolny H, Schott BH, Gorny X, Becker V, Steiner J, Seidenbecher CI, Bogerts B. 2013. Increased density of AKAP5-expressing neurons in the anterior cingulate cortex of subjects with bipolar disorder. Journal of Psychiatric Research. 47(6):699-705.

    Richter A, Richter S, Barman A, Soch J, Klein M, Assmann A, Libeau C, Behnisch G, Wüstenberg T, Seidenbecher CI, Schott BH. 2013. Motivational salience and genetic variability of dopamine D2 receptor expression interact in the modulation of interference processing. Frontiers in Human Neuroscience. 7(MAY).

    Susuki K, Chang KJ, Zollinger DR, Liu Y, Ogawa Y, Eshed-Eisenbach Y, Dours-Zimmermann MT, Oses-Prieto JA, Burlingame AL, Seidenbecher CI, Zimmermann DR, Oohashi T, Peles E, Rasband MN. 2013. Three mechanisms assemble central nervous system nodes of ranvier. Neuron. 78(3):469-482.

    Schott BH, Wüstenberg T, Wimber M, Fenker DB, Zierhut KC, Seidenbecher CI, Heinze HJ, Walter H, Düzel E, Richardson-Klavehn A. 2013. The relationship between level of processing and hippocampal-cortical functional connectivity during episodic memory formation in humans. Human Brain Mapping. 34(2):407-424.

    Richter S, Gorny X, Machts J, Behnisch G, Wüstenberg T, Herbort MC, Münte TF, Seidenbecher CI, Schott BH. 2013. Effects of AKAP5 Pro100Leu Genotype on Working Memory for Emotional Stimuli. PLoS ONE. 8(1):Article e55613.

    Seeger C, Gorny X, Reddy PP, Seidenbecher C, Danielson UH. 2012. Kinetic and mechanistic differences in the interactions between caldendrin and calmodulin with AKAP79 suggest different roles in synaptic function. Journal of Molecular Recognition. 25(10):495-503.

    Miró X, Meier S, Dreisow ML, Frank J, Strohmaier J, Breuer R, Schmäl C, Albayram Ö, Pardo-Olmedilla MT, Mühleisen TW, Degenhardt FA, Mattheisen M, Reinhard I, Bilkei-Gorzo A, Cichon S, Seidenbecher C, Rietschel M, Nöthen MM, Zimmer A. 2012. Studies in humans and mice implicate neurocan in the etiology of mania. American Journal of Psychiatry. 169(9):982-990.

    Gorny X, Mikhaylova M, Seeger C, Reddy PP, Reissner C, Schott BH, Helena Danielson U, Kreutz MR, Seidenbecher C. 2012. AKAP79/150 interacts with the neuronal calcium-binding protein caldendrin. Journal of Neurochemistry. 122(4):714-726.

    Frischknecht R, Seidenbecher CI. 2012. Brevican: A key proteoglycan in the perisynaptic extracellular matrix of the brain. International Journal of Biochemistry and Cell Biology. 44(7):1051-1054.

    Herrera-Molina R, Frischknecht R, Maldonado H, Seidenbecher CI, Gundelfinger ED, Hetz C, de la Luz Aylwin M, Schneider P, Quest AFG, Leyton L. 2012. Astrocytic α vβ 3 integrin inhibits neurite outgrowth and promotes retraction of neuronal processes by clustering thy-1. PLoS ONE. 7(3):e34295.

    Richter S, Gorny X, Marco-Pallares J, Krämer UM, Machts J, Barman A, Bernstein HG, Schüle R, Schöls L, Rodriguez-Fornells A, Reissner C, Wüstenberg T, Heinze HJ, Gundelfinger ED, Düzel E, Münte TF, Seidenbecher CI, Schott BH. 2011. A potential role for a genetic variation of AKAP5 in human aggression and anger control. Frontiers in Human Neuroscience. 5(DEC):Article 175.

    Heyden A, Ionescu MCS, Romorini S, Kracht B, Ghiglieri V, Calabresi P, Seidenbecher C, Angenstein F, Gundelfinger ED. 2011. Hippocampal enlargement in Bassoon-mutant mice is associated with enhanced neurogenesis, reduced apoptosis, and abnormal BDNF levels. Cell and Tissue Research. 346(1):11-26.

    Wimber M, Schott BH, Wendler F, Seidenbecher CI, Behnisch G, Macharadze T, Bäuml KHT, Richardson-Klavehn A. 2011. Prefrontal dopamine and the dynamic control of human long-term memory. Translational Psychiatry. 1:Article e15.

    Schott BH, Seidenbecher CI, Richter S, Wüstenberg T, Debska-Vielhaber G, Schubert H, Heinze HJ, Richardson-Klavehn A, Düzel E. 2011. Genetic variation of the serotonin 2a receptor affects hippocampal novelty processing in humans. PLoS ONE. 6(1):e15984.

    Zweynert S, Pade JP, Wüstenberg T, Sterzer P, Walter H, Seidenbecher CI, Richardson-Klavehn A, Düzel E, Schott BH. 2011. Motivational salience modulates hippocampal repetition suppression and functional connectivity in humans. Frontiers in Human Neuroscience. 5:144.

    Pyka M, Busse C, Seidenbecher C, Gundelfinger ED, Faissner A. 2011. Astrocytes are crucial for survival and maturation of embryonic hippocampal neurons in a neuron-glia cell-insert coculture assay. Synapse. 65(1):41-53.

    Dityatev A, Seidenbecher CI, Schachner M. 2010. Compartmentalization from the outside: The extracellular matrix and functional microdomains in the brain. Trends in Neurosciences. 33(11):503-512.

    Faissner A, Pyka M, Geissler M, Sobik T, Frischknecht R, Gundelfinger ED, Seidenbecher C. 2010. Contributions of astrocytes to synapse formation and maturation - Potential functions of the perisynaptic extracellular matrix. Brain Research Reviews. 63(1-2):26-38.

    Schott BH, Frischknecht R, Debska-Vielhaber G, John N, Behnisch G, Düzel E, Gundelfinger ED, Seidenbecher CI. 2010. Membrane-bound catechol-O-methyl transferase in cortical neurons and glial cells is intracellularly oriented. Frontiers in Psychiatry. 1(OCT):Article Article 142.

    Frischknecht R, Heine M, Perrais D, Seidenbecher CI, Choquet D, Gundelfinger ED. 2009. Brain extracellular matrix affects AMPA receptor lateral mobility and short-term synaptic plasticity. Neuroforum. 15(3):94-95.

    Frischknecht R, Heine M, Perrais D, Seidenbecher CI, Choquet D, Gundelfinger ED. 2009. Brain extracellular matrix affects AMPA receptor lateral mobility and short-term synaptic plasticity. Nature Neuroscience. 12(7):897-904.

    Schott BH, Minuzzi L, Krebs RM, Elmenhorst D, Lang M, Winz OH, Seidenbecher CI, Coenen HH, Heinze HJ, Zilles K, Düzel E, Bauer A. 2008. Mesolimbic functional magnetic resonance imaging activations during reward anticipation correlate with reward-related ventral striatal dopamine release. Journal of Neuroscience. 28(52):14311-14319.

    Schicknick H, Schott BH, Budinger E, Smalla KH, Riedel A, Seidenbecher CI, Scheich H, Gundelfinger ED, Tischmeyer W. 2008. Dopaminergic modulation of auditory cortex-dependent memory consolidation through mTOR. Cerebral Cortex. 18(11):2646-2658.

    Frischknecht R, Seidenbecher CI. 2008. The crosstalk of hyaluronan-based extracellular matrix and synapses. Neuron Glia Biology. 4(3):249-257.

    Heyden A, Angenstein F, Sallaz M, Seidenbecher C, Montag D. 2008. Abnormal axonal guidance and brain anatomy in mouse mutants for the cell recognition molecules close homolog of L1 and NgCAM-related cell adhesion molecule. Neuroscience. 155(1):221-233.

    Dieterich DC, Karpova A, Mikhaylova M, Zdobnova I, König I, Landwehr M, Kreutz M, Smalla KH, Richter K, Landgraf P, Reissner C, Boeckers TM, Zuschratter W, Spilker C, Seidenbecher CI, Garner CC, Gundelfinger ED, Kreutz MR. 2008. Caldendrin-Jacob: A protein liaison that couples NMDA receptor signalling to the nucleus. PLoS Biology. 6(2):286-306.

    Quaglia X, Beggah AT, Seidenbecher C, Zurn AD. 2008. Delayed priming promotes CNS regeneration post-rhizotomy in Neurocan and Brevican-deficient mice. Brain. 131(1):240-249.

    Schott BH, Niehaus L, Wittmann BC, Schütze H, Seidenbecher CI, Heinze HJ, Düzel E. 2007. Ageing and early-stage Parkinson's disease affect separable neural mechanisms of mesolimbic reward processing. Brain. 130(9):2412-2424.

    Hedstrom KL, Xu X, Ogawa Y, Frischknecht R, Seidenbecher CI, Shrager P, Rasband MN. 2007. Neurofascin assembles a specialized extracellular matrix at the axon initial segment. Journal of Cell Biology. 178(5):875-886.

    Dityatev A, Frischknecht R, Seidenbecher C. 2006. Extracellular Matrix and Synaptic Functions. Gundelfinger ED, Seidenbecher C, Schraven B, editors. In Cell Communication in Nervous and Immune System. Springer. pp. 69-97. (Results and Problems in Cell Differentiation).

    John N, Krügel H, Frischknecht R, Smalla KH, Schultz C, Kreutz MR, Gundelfinger ED, Seidenbecher CI. 2006. Brevican-containing perineuronal nets of extracellular matrix in dissociated hippocampal primary cultures. Molecular and Cellular Neurosciences. 31(4):774-784.

    Krügel H, Becker A, Polten A, Grecksch G, Singh R, Berg A, Seidenbecher C, Saluz HP. 2006. Transcriptional response to the neuroleptic-like compound Ampullosporin A in the rat ketamine model.Journal of Neurochemistry. 97 Suppl 1:74-81.

    Schott BH, Seidenbecher CI, Fenker DB, Lauer CJ, Bunzeck N, Bernstein HG, Tischmeyer W, Gundelfinger ED, Heinze HJ, Düzel E. 2006. The dopaminergic midbrain participates in human episodic memory formation: Evidence from genetic imaging. Journal of Neuroscience. 26(5):1407-1417.

    Held-Feindt J, Paredes EB, Blömer U, Seidenbecher C, Stark AM, Mehdorn HM, Mentlein R. 2006. Matrix-degrading proteases ADAMTS4 and ADAMTS5 (disintegrins and metalloproteinases with thrombospondin motifs 4 and 5) are expressed in human glioblastomas. International Journal of Cancer. 118(1):55-61.

    Kreutz MR, Seidenbecher C, Gundelfinger ED. 2006. Caldendrin- a neuronal calcium binding protein involved in synaptro-dendritic Ca2+ signaling. Philippov PP, Koch K-W, editors. In Neuronal Calcium Sensor Proteins. New York: Nova Science Publishers. pp. 301-313.

    Gundelfinger ED, Seidenbecher C, Schraven B, ed. 2006. Cell Communication in Nervous and Immune System. 1 ed. Heidelberg: Springer Verlag. 313 p. (Results and Problems in Cell Differentiation).

    Gundelfinger ED, Seidenbecher C, Schraven B. 2006. Preface. Gundelfinger ED, Seidenbecher C, Schraven B, editors. In Cell Communication in Nervous and Immune System. Springer. pp. v-vii. ( Results and Problems in Cell Differentiation ).

    Seidenbecher CI, Landwehr M, Smalla KH, Kreutz M, Dieterich DC, Zuschratter W, Reissner C, Hammarback JA, Böckers TM, Gundelfinger ED, Kreutz MR. 2004. Caldendrin but not Calmodulin Binds to Light Chain 3 of MAP1A/B: An Association with the Microtubule Cytoskeleton Highlighting Exclusive Binding Partners for Neuronal Ca2+-sensor Proteins. Journal of Molecular Biology. 336(4):957-970.

    Smalla KH, Seidenbecher CI, Tischmeyer W, Schicknick H, Wyneken U, Böckers TM, Gundelfinger ED, Kreutz MR. 2003. Kainate-induced epileptic seizures induce a recruitment of caldendrin to the postsynaptic density in rat brain. Molecular Brain Research. 116(1-2):159-162.

    Bernstein HG, Seidenbecher CI, Smalla KH, Gundelfinger ED, Bogerts B, Kreutz MR. 2003. Distribution and cellular localization of caldendrin immunoreactivity in adult human forebrain. Journal of Histochemistry and Cytochemistry. 51(8):1109-1112.

    Tischmeyer W, Schicknick H, Kraus M, Seidenbecher CI, Staak S, Scheich H, Gundelfinger ED. 2003. Rapamycin-sensitive signalling in long-term consolidation of auditory cortex-dependent memory. European Journal of Neuroscience. 18(4):942-950.

    Brakebusch C, Seidenbecher CI, Asztely F, Rauch U, Matthies H, Meyer H, Krug M, Böckers TM, Zhou X, Kreutz MR, Montag D, Gundelfinger ED, Fässler R. 2002. Brevican-deficient mice display impaired hippocampal CA1 long-term potentiation but show no obvious deficits in learning and memory. Molecular and Cellular Biology. 22(21):7417-7427.

    Seidenbecher CI, Smalla KH, Fischer N, Gundelfinger ED, Kreutz MR. 2002. Brevican isoforms associate with neural membranes. Journal of Neurochemistry. 83(3):738-746.

    Laube G, Seidenbecher CI, Richter K, Dieterich DC, Hoffmann B, Landwehr M, Smalla KH, Winter C, Böckers TM, Wolf G, Gundelfinger ED, Kreutz MR. 2002. The neuron-specific Ca2+-binding protein caldendrin: Gene structure, splice isoforms, and expression in the rat central nervous system. Molecular and Cellular Neurosciences. 19(3):459-475.

    Seidenbecher CI, Reissner C, Kreutz MR. 2002. Caldendrins in the inner retina. Experimental Biology and Medicine. 514:451-463.

    Zhou XH, Brakebusch C, Matthies H, Oohashi T, Hirsch E, Moser M, Krug M, Seidenbecher CI, Boeckers TM, Rauch U, Buettner R, Gundelfinger ED, Fässler R. 2001. Neurocan is dispensable for brain development. Molecular and Cellular Biology. 21(17):5970-5978.

    Kreutz MR, Langnäse K, Dieterich DC, Seidenbecher CI, Zuschratter W, Beesley PW, Gundelfinger ED. 2001. Distribution of transcript and protein isoforms of the synaptic glycoprotein neuroplastin in rat retina. Investigative Ophthalmology and Visual Science. 42(8):1907-1914.

    Brückner G, Grosche J, Schmidt S, Härtig W, Margolis RU, Delpech B, Seidenbecher CI, Czaniera R, Schachner M. 2000. Postnatal development of perineuronal nets in wild-type mice and in a mutant deficient in tenascin-R. Journal of Comparative Neurology. 428(4):616-629.<616::AID-CNE3>3.0.CO;2-K

    Boeckers TM, Winter C, Smalla KH, Kreutz MR, Bockmann J, Seidenbecher C, Garner CC, Gundelfinger ED. 1999. Proline-rich synapse-associated proteins ProSAP1 and ProSAP2 interact with synaptic proteins of the SAPAP/GKAP family. Biochemical and Biophysical Research Communications. 264(1):247-252.

    Menger N, Seidenbecher CI, Gundelfinger ED, Kreutz MR. 1999. The Cytoskeleton-associated neuronal calcium-binding protein caldendrin is expressed in a subset of amacrine, bipolar and ganglion cells of the rat retina. Cell and Tissue Research. 298(1):21-32.

    Kreutz MR, Bien A, Vorwerk CK, Böckers TM, Seidenbecher CI, Tischmeyer W, Sabel BA. 1999. Co-expression of c-Jun and ATF-2 characterizes the surviving retinal ganglion cells which maintain axonal connections after partial optic nerve injury. Molecular Brain Research. 69(2):232-241.

    Bien A, Seidenbecher CI, Böckers TM, Sabel BA, Kreutz MR. 1999. Apoptotic versus necrotic characteristics of retinal ganglion cell death after partial optic nerve injury. Journal of Neurotrauma. 16(2):153-163.

    Kreutz MR, Seidenbecher CI, Sabel BA. 1999. Molecular plasticity of retinal ganglion cells after partial optic nerve injury. Restorative Neurology and Neuroscience. 14(2-3):127-134.

    Kreutz MR, Böckers TM, Bockmann J, Seidenbecher CI, Kracht B, Vorwerk CK, Weise J, Sabel BA. 1998. Axonal injury alters alternative splicing of the retinal NR1 receptor: The preferential expression of the NR1b isoforms is crucial for retinal ganglion cell survival. Journal of Neuroscience. 18(20):8278-8291.

    Seidenbecher CI, Langnäse K, Sanmartí-Vila L, Boeckers TM, Smalla KH, Sabel BA, Garner CC, Gundelfinger ED, Kreutz MR. 1998. Caldendrin, a novel neuronal calcium-binding protein confined to the somato-dendritic compartment. Journal of Biological Chemistry. 273(33):21324-21331.

    Seidenbecher CI, Gundelfinger ED, Böckers TM, Trotter J, Kreutz MR. 1998. Transcripts for secreted and GPI-anchored brevican are differentially distributed in rat brain. European Journal of Neuroscience. 10(5):1621-1630.

    Rauch U, Meyer H, Brakebusch C, Seidenbecher C, Gundelfinger ED, Beier DR, Fässler R. 1997. Sequence and chromosomal localization of the mouse brevican gene. Genomics. 44(1):15-21.

    Seidenbecher C, Richter K, Gundelfinger ED. 1997. Brevican, a conditional proteoglycan from rat brain: Characterisation of secreted and GPI-Anchored Isoforms. Teelken A, Korf J, editors. In Neurochemistry: Cellular, Molecular, and clinical aspects. New York and London: Plenum Press. pp. 901-904.

    Langnaese K, Seidenbecher C, Wex H, Seidel B, Hartung K, Appeltauer U, Garner A, Voss B, Mueller B, Garner CC, Gundelfinger ED. 1996. Protein components of a rat brain synaptic junctional protein preparation. Molecular Brain Research. 42(1):118-122.

    Chung WJ, Kindler S, Seidenbecher C, Garner CC. 1996. MAP2a, an alternatively spliced variant of microtubule-associated protein 2. Journal of Neurochemistry. 66(3):1273-1281.

    Seidenbecher CI, Richter K, Rauch U, Fassler R, Garner CC, Gundelfinger ED. 1995. Brevican, a chondroitin sulfate proteoglycan of rat brain, occurs as secreted and cell surface glycosylphosphatidylinositol-anchored isoforms. Journal of Biological Chemistry. 270(45):27206-27212.

    Reinbothe S, Reinbothe C, Heintzen C, Seidenbecher C, Parthier B. 1993. A methyl jasmonate-induced shift in the length of the 5' untranslated region impairs translation of the plastid rbcL transcript in barley. EMBO Journal. 12(4):1505-1512.
  • Third party funds

    Third party funds

    2020 - 2024 (DFG)
    SFB 1436 TP A05: Die Integrität der Extrazellulären Matrix als neuronale Ressource kognitiver Flexibilität

    2019 - 2023 (DFG)
    Die alternde Synapse - molekulare, zelluläre und verhaltensbiologische Mechanismen des kognitiven Leistungsabfalls

    2014 - 2019 (DFG)
    SFB 779/ B14: Zusammenspiel vom dopaminergen System und der Extrazellulärmatrix beim aversiven Lernen

    2012 - 2016 (DFG)
    SFB 779/ A08: Genetische Einflüsse auf die Modulation von Aufmerksamkeit und Gedächtnis durch Belohnung und Bestrafung

    2011 - 2015 (WGL)
    SAW-2011-IfN-4: TP 2: Imaging Genetics kognitiver Funtkionen

Share this page: