LIN Staff

Prof. Dr. Max Happel

Head of Working Group

Systems Physiology of Learning

Leibniz Institute for Neurobiology
Brenneckestr. 6
39118 Magdeburg
Phone: +49 391 6263 93481

  • Publications


    Caras ML, Happel MFK, Chandrasekaran B, Ripollés P, Keesom SM, Hurley LM, Remage-Healey L, Holt LL, Wright BA. 2022. Non-sensory Influences on Auditory Learning and Plasticity. JARO - Journal of the Association for Research in Otolaryngology. 23(2):151-166.

    Happel MFK, Hechavarria JC, de Hoz L. 2022. Editorial: Cortical-Subcortical Loops in Sensory Processing. Frontiers in neural circuits. 16:Article 851612.

    Saldeitis K, Jeschke M, Budinger E, Ohl FW, Happel MFK. 2021. Laser-Induced Apoptosis of Corticothalamic Neurons in Layer VI of Auditory Cortex Impact on Cortical Frequency Processing. Frontiers in neural circuits. 15:Article 659280.

    Lin X, Brunk MGK, Yuanxiang P, Curran AW, Zhang E, Stöber F, Goldschmidt J, Gundelfinger ED, Vollmer M, Happel MFK, Herrera-Molina R, Montag D. 2021. Neuroplastin expression is essential for hearing and hair cell PMCA expression. Brain Structure and Function. 226(5):1533-1551.

    El-Tabbal M, Niekisch H, Henschke JU, Budinger E, Frischknecht R, Deliano M, Happel MFK. 2021. The extracellular matrix regulates cortical layer dynamics and cross-columnar frequency integration in the auditory cortex. Communications biology. 4(1):Article 322.

    Jeschke M, Happel MFK, Tziridis K, Krauss P, Schilling A, Schulze H, Ohl FW. 2021. Acute and Long-Term Circuit-Level Effects in the Auditory Cortex After Sound Trauma. Frontiers in Neuroscience. 14:Article 598406.

    Zempeltzi MM, Kisse M, Brunk MGK, Glemser C, Aksit S, Deane KE, Maurya S, Schneider L, Ohl FW, Deliano M, Happel MFK. 2020. Task rule and choice are reflected by layer-specific processing in rodent auditory cortical microcircuits. Communications biology. 3(1):Article 345.

    Deane KE, Brunk MGK, Curran AW, Zempeltzi MM, Ma J, Lin X, Abela F, Aksit S, Deliano M, Ohl FW, Happel MFK. 2020. Ketamine anaesthesia induces gain enhancement via recurrent excitation in granular input layers of the auditory cortex. Journal of Physiology. 598(13):2741-2755.

    Deliano M, Brunk MGK, El-Tabbal M, Zempeltzi MM, Happel MFK, Ohl FW. 2020. Dopaminergic neuromodulation of high gamma stimulus phase-locking in gerbil primary auditory cortex mediated by D1/D5-receptors. European Journal of Neuroscience. 51(5):1315-1327.

    Mitlöhner J, Kaushik R, Niekisch H, Blondiaux A, Gee CE, Happel MFK, Gundelfinger E, Dityatev A, Frischknecht R, Seidenbecher C. 2020. Dopamine Receptor Activation Modulates the Integrity of the Perisynaptic Extracellular Matrix at Excitatory Synapses. Cells. 9(2):Article 260.

    Brunk MGK, Deane KE, Kisse M, Deliano M, Vieweg S, Ohl FW, Lippert MT, Happel MFK. 2019. Optogenetic stimulation of the VTA modulates a frequency-specific gain of thalamocortical inputs in infragranular layers of the auditory cortex. Scientific Reports. 9(1):Article 20385.

    Niekisch H, Steinhardt J, Berghäuser J, Bertazzoni S, Kaschinski E, Kasper J, Kisse M, Mitlöhner J, Singh JB, Weber J, Frischknecht R, Happel MFK. 2019. Learning induces transient upregulation of brevican in the auditory cortex during consolidation of long-term memories. Journal of Neuroscience. 39(36):7049-7060.

    Happel M 2018. Corticale Schaltkreise des Hörens - Funktionelle Organisation, Verhalten und translationale Ansätze. Magdeburg: Otto-von-Guericke-Univ. Magdeburg.

    Homma NY, Happel MFK, Nodal FR, Ohl FW, King AJ, Bajo VM. 2017. A role for auditory corticothalamic feedback in the perception of complex sounds. Journal of Neuroscience. 37(25):6149-6161.

    Happel MFK, Ohl FW. 2017. Compensating level-dependent frequency representation in auditory cortex by synaptic integration of corticocortical input. PLoS ONE. 12(1):Article e0169461.

    Homma NY, Bajo VM, Happel MFK, Nodal FR, King AJ. 2016. Mistuning detection performance of ferrets in a go/no-go task. Journal of the Acoustical Society of America. 139(6):EL246-EL251.

    Happel MFK. 2016. Dopaminergic impact on local and global cortical circuit processing during learning. Behavioural Brain Research. 299:32-41.

    Frischknecht R, Happel MFK. 2016. Einfluss der Extrazellulären Matrix auf plastische Prozesse in jungen und alten Gehirnen: Extrazelluläre Matrix und Hirnplastizität. Neuroforum. 22(1):1-9.

    Mylius J, Happel MFK, Gorkin AG, Huang Y, Scheich H, Brosch M. 2015. Fast transmission from the dopaminergic ventral midbrain to the sensory cortex of awake primates. Brain Structure and Function. 220(6):3273-3294.

    Happel MFK, Deliano M, Ohl FW. 2015. Combined shuttle-box training with electrophysiological cortex recording and stimulation as a tool to study perception and learning. Journal of Visualized Experiments. 2015(105):Article e53002.

    Tziridis K, Ahlf S, Jeschke M, Happel MFK, Ohl FW, Schulze H. 2015. Noise trauma induced neural plasticity throughout the auditory system of Mongolian gerbils: Differences between tinnitus developing and non-developing animals. Frontiers in Neurology. 6:22.

    Saldeitis K, Happel MFK, Ohl FW, Scheich H, Budinger E. 2014. Anatomy of the auditory thalamocortical system in the mongolian gerbil: Nuclear origins and cortical field-, layer-, and frequency-specificities. Journal of Comparative Neurology. 522(10):2397-2430.

    Meyer AF, Diepenbrock JP, Happel MFK, Ohl FW, Anemüller J. 2014. Discriminative learning of receptive fields from responses to non-gaussian stimulus ensembles. PLoS ONE. 9(4):Article e93062.

    Lison H, Happel MFK, Schneider F, Baldauf K, Kerbstat S, Seelbinder B, Schneeberg J, Zappe M, Goldschmidt J, Budinger E, Schröder UH, Ohl FW, Schilling S, Demuth HU, Scheich H, Reymann KG, Rönicke R. 2014. Disrupted cross-laminar cortical processing in β amyloid pathology precedes cell death. Neurobiology of Disease. 63:62-73.

    Happel MFK, Niekisch H, Castiblanco Rivera LL, Ohl FW, Deliano M, Frischknecht R. 2014. Enhanced cognitive flexibility in reversal learning induced by removal of the extracellular matrix in auditory cortex. Proceedings of the National Academy of Sciences of the United States of America. 111(7):2800-2805.

    Happel MFK, Deliano M, Handschuh J, Ohl FW. 2014. Dopamine-modulated recurrent corticoefferent feedback in primary sensory cortex promotes detection of behaviorally relevant stimuli. Journal of Neuroscience. 34(4):1234-1247.

    Happel MFK, Jeschke M, Ohl FW. 2010. Spectral integration in primary auditory cortex attributable to temporally precise convergence of thalamocortical and intracortical input. Journal of Neuroscience. 30(33):11114-11127.

    Goldschmidt J, Wanger T, Engelhorn A, Friedrich H, Happel M, Ilango A, Engelmann M, Stuermer IW, Ohl FW, Scheich H. 2010. High-resolution mapping of neuronal activity using the lipophilic thallium chelate complex TlDDC: Protocol and validation of the method. NeuroImage. 49(1):303-315.

    Moeller CK, Kurt S, Happel MFK, Schulze H. 2010. Long-range effects of GABAergic inhibition in gerbil primary auditory cortex. European Journal of Neuroscience. 31(1):49-59.

    Meyer A, Happel M, Ohl F, Anemüller J. 2009. Estimation of spectro-temporal receptive fields based on linear support vector machine classification. In BMC Neuroscience. Suppl I ed. BioMed Central. pp. P147.

    Happel MFK, Müller S, Anemüller J, Ohl FW. 2008. Predictability of STRFs in auditory cortex neurons depends on stimulus class. In Proceedings of the Annual Conference of the International Speech Communication Association, INTERSPEECH. pp. 670.
  • Third party funds

    Third party funds

    2020 - 2024 (DFG)
    SFB 1436 TP C02: Explorative Aufmerksamkeitsressourcenallokation durch den anterioren präfrontalen Kortex

    2020 - 2023 (DFG)
    Regulation der extrazellulären Matrix durch Dopamin während des Lernens im erwachsenen Alter.

    2016 - 2019 (DFG)
    SFB 779/ TP16: Werte-Repräsentation in sensorischen kortikalen Arealen während Entscheidungsprozessen: Netzwekmechanismen und Neuromodulation

    2015 - 2018 (WGL)
    SAW-2015-LIN-3: Monoaminergic impact on neural circuits - a Leibniz Postdoctoral Network

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