LIN Staff

Dr. Rodrigo Herrera-Molina

Scientist

Combinatorial NeuroImaging

Leibniz Institute for Neurobiology
Brenneckestr. 6
39118 Magdeburg
Germany
Phone: +49 391 6263 92431
Email: Rodrigo.Herrera-Molina@lin-magdeburg.de

Publications
Publications
Malci A, Lin X, Shi YS, Herrera-Molina R. 2023. Neuroplastin in Ca2+ signal regulation and plasticity of glutamatergic synapses. Neural Regeneration Research. 18(8):1705-1706. https://doi.org/10.4103/1673-5374.363826
Malci A, Sandoval R, Gundelfinger ED, Naumann M, Seidenbecher C, Herrera-Molina R. 2022. Ca2+ signaling in postsynaptic neurons: neuroplastin-65 regulates the interplay between plasma membrane Ca2+ ATPases and ionotropic glutamate receptors. Cell calcium. 106:Article 102623. https://doi.org/10.1016/j.ceca.2022.102623
Guzmán Salas S, Weber A, Malci A, Lin X, Herrera-Molina R, Cerpa W, Dorador C, Signorelli J, Zamorano P. 2022. The metabolite p-cresol impairs dendritic development, synaptogenesis and synapse function in hippocampal neurons: Implications for autism spectrum disorder. Journal of Neurochemistry. 161(4):335-349. https://doi.org/10.1111/jnc.15604
Ilic K, Lin X, Malci A, Stojanović M, Puljko B, Rožman M, Vukelić Ž, Heffer M, Montag D, Schnaar RL, et al. 2021. Plasma membrane calcium ATPase-neuroplastin complexes are selectively stabilized in GM1-containing lipid rafts. International Journal of Molecular Sciences. 22(24):Article 13590. https://doi.org/10.3390/ijms222413590
Lin X, Liang Y, Herrera-Molina R, Montag D. 2021. Neuroplastin in Neuropsychiatric Diseases. Genes. 12(10):Article 1507. https://doi.org/10.3390/genes12101507
Lin X, Brunk MGK, Yuanxiang P, Curran AW, Zhang E, Stöber F, Goldschmidt J, Gundelfinger ED, Vollmer M, Happel MFK, et al. 2021. Neuroplastin expression is essential for hearing and hair cell PMCA expression. Brain Structure and Function. 226(5):1533-1551. https://doi.org/10.1007/s00429-021-02269-w
Vemula SK, Malci A, Junge L, Lehmann AC, Rama R, Hradsky J, Matute RA, Weber A, Prigge M, Naumann M, et al. 2020. The Interaction of TRAF6 With Neuroplastin Promotes Spinogenesis During Early Neuronal Development. Frontiers in Cell and Developmental Biology. 8:Article 579513. https://doi.org/10.3389/fcell.2020.579513
García F, Lobos P, Ponce A, Cataldo K, Meza D, Farías P, Estay C, Oyarzun-Ampuero F, Herrera-Molina R, Paula-Lima A, et al. 2020. Astaxanthin Counteracts Excitotoxicity and Reduces the Ensuing Increases in Calcium Levels and Mitochondrial Reactive Oxygen Species Generation. Marine drugs. 18(6):Article 335. https://doi.org/10.3390/md18060335
Luarte A, Henzi R, Fernández A, Gaete D, Cisternas P, Pizarro M, Batiz LF, Villalobos I, Masalleras M, Vergara R, et al. 2020. Astrocyte-Derived Small Extracellular Vesicles Regulate Dendritic Complexity through miR-26a-5p Activity. Cells. 9(4):Article 930. https://doi.org/10.3390/cells9040930
Ilic K, Auer B, Mlinac-Jerkovic K, Herrera-Molina R. 2019. Neuronal Signaling by Thy-1 in Nanodomains With Specific Ganglioside Composition: Shall We Open the Door to a New Complexity?. Frontiers in Cell and Developmental Biology. 7:Article 27. https://doi.org/10.3389/fcell.2019.00027
Bruna B, Lobos P, Herrera-Molina R, Hidalgo C, Paula-Lima A, Adasme T. 2018. The signaling pathways underlying BDNF-induced Nrf2 hippocampal nuclear translocation involve ROS, RyR-Mediated Ca2+ signals, ERK and PI3K. Biochemical and Biophysical Research Communications. 505(1):201-207. https://doi.org/10.1016/j.bbrc.2018.09.080
Lang D, Schott BH, van Ham M, Morton L, Kulikovskaja L, Herrera-Molina R, Pielot R, Klawonn F, Montag D, Jänsch L, et al. 2018. Chronic Toxoplasma infection is associated with distinct alterations in the synaptic protein composition. Journal of Neuroinflammation. 15(1):Article 216. https://doi.org/10.1186/s12974-018-1242-1
Lagos-Cabré R, Brenet M, Díaz J, Pérez RD, Pérez LA, Herrera-Molina R, Quest AFG, Leyton L. 2018. Intracellular ca²⁺ increases and connexin 43 hemichannel opening are necessary but not sufficient for thy-1-induced astrocyte migration. International Journal of Molecular Sciences. 19(8):Article 2179. https://doi.org/10.3390/ijms19082179
Lagos-Cabré R, Alvarez A, Kong M, Burgos-Bravo F, Cárdenas A, Rojas-Mancilla E, Pérez-Nuñez R, Herrera-Molina R, Rojas F, Schneider P, et al. 2017. α_Vβ₃ Integrin regulates astrocyte reactivity. Journal of Neuroinflammation. 14(1):Article 194. https://doi.org/10.1186/s12974-017-0968-5
Korthals M, Langnaese K, Smalla KH, Kähne T, Herrera-Molina R, Handschuh J, Lehmann AC, Mamula D, Naumann M, Seidenbecher C, et al. 2017. A complex of Neuroplastin and Plasma Membrane Ca²⁺ ATPase controls T cell activation. Scientific Reports. 7(1):Article 8358. https://doi.org/10.1038/s41598-017-08519-4
Herrera-Molina R, Mlinac-Jerkovic K, Ilic K, Stöber F, Vemula SK, Sandoval M, Milosevic NJ, Simic G, Smalla KH, Goldschmidt J, et al. 2017. Neuroplastin deletion in glutamatergic neurons impairs selective brain functions and calcium regulation: Implication for cognitive deterioration. Scientific Reports. 7(1):Article 7273. https://doi.org/10.1038/s41598-017-07839-9
Maldonado H, Calderon C, Burgos-Bravo F, Kobler O, Zuschratter W, Ramirez O, Härtel S, Schneider P, Quest AFG, Herrera-Molina R, et al. 2017. Astrocyte-to-neuron communication through integrin-engaged Thy-1/CBP/Csk/Src complex triggers neurite retraction via the RhoA/ROCK pathway. Biochimica et Biophysica Acta - Molecular Cell Research. 1864(2):243-254. https://doi.org/10.1016/j.bbamcr.2016.11.006
Bhattacharya S, Herrera-Molina R, Sabanov V, Ahmed T, Iscru E, Stöber F, Richter K, Fischer KD, Angenstein F, Goldschmidt J, et al. 2017. Genetically induced retrograde amnesia of associative memories after neuroplastin ablation. Biological Psychiatry. 81(2):124-135. https://doi.org/10.1016/j.biopsych.2016.03.2107
Beesley PW, Herrera-Molina R, Smalla KH, Seidenbecher C. 2014. The Neuroplastin adhesion molecules: key regulators of neuronal plasticity and synaptic function. Journal of Neurochemistry. 131(3):268-283. https://doi.org/10.1111/jnc.12816
Herrera Molina R, Sarto-Jackson I, Montenegro-Venegas C, Heine M, Smalla KH, Seidenbecher CI, Beesley PW, Gundelfinger ED, Montag D. 2014. Structure of excitatory synapses and GABAA receptor localization at inhibitory synapses are regulated by neuroplastin-65. Journal of Biological Chemistry. 289(13):8973-8988. https://doi.org/10.1074/jbc.M113.514992
Sandoval M, Luarte A, Herrera-Molina R, Varas-Godoy M, Santibáñez M, Rubio FJ, Smit AB, Gundelfinger ED, Li KW, Smalla KH, et al. 2013. The glycolytic enzyme aldolase C is up-regulated in rat forebrain microsomes and in the cerebrospinal fluid after repetitive fluoxetine treatment. Brain Research. 1520:1-14. https://doi.org/10.1016/j.brainres.2013.04.049
Kong M, Muñoz N, Valdivia A, Alvarez A, Herrera-Molina R, Cárdenas A, Schneider P, Burridge K, Quest AFG, Leyton L. 2013. Thy-1-mediated cell-cell contact induces astrocyte migration through the engagement of α_Vβ₃ integrin and syndecan-4. Biochimica et Biophysica Acta - Molecular Cell Research. 1833(6):1409-1420. https://doi.org/10.1016/j.bbamcr.2013.02.013
Herrera-Molina R, Valdivia A, Kong M, Alvarez A, Cárdenas A, Quest AFG, Leyton L. 2013. Thy-1-interacting molecules and cellular signaling in Cis and Trans. International Review of Cell and Molecular Biology. 305:163-216. https://doi.org/10.1016/B978-0-12-407695-2.00004-4
Herrera-Molina R, Flores B, Orellana JA, Von Bernhardi R. 2012. Modulation of interferon-γ-induced glial cell activation by transforming growth factor β1: A role for STAT1 and MAPK pathways. Journal of Neurochemistry. 123(1):113-123. https://doi.org/10.1111/j.1471-4159.2012.07887.x
Sarto-Jackson I, Milenkovic I, Smalla KH, Gundelfinger ED, Kaehne T, Herrera-Molina R, Thomas S, Kiebler MA, Sieghart W. 2012. The cell adhesion molecule neuroplastin-65 is a novel interaction partner of γ-aminobutyric acid type A receptors. Journal of Biological Chemistry. 287(17):14201-14214. https://doi.org/10.1074/jbc.M111.293175
Herrera-Molina R, Frischknecht R, Maldonado H, Seidenbecher CI, Gundelfinger ED, Hetz C, de la Luz Aylwin M, Schneider P, Quest AFG, Leyton L. 2012. Astrocytic α _vβ ₃ integrin inhibits neurite outgrowth and promotes retraction of neuronal processes by clustering thy-1. PLoS ONE. 7(3):e34295. https://doi.org/10.1371/journal.pone.0034295
Henríquez M, Herrera-Molina R, Valdivia A, Alvarez A, Kong M, Muñoz N, Eisner V, Jaimovich E, Schneider P, Quest AFG, et al. 2011. ATP release due to Thy-1-integrin binding induces P2X7-mediated calcium entry required for focal adhesion formation. Journal of Cell Science. 124(9):1581-1588. https://doi.org/10.1242/jcs.073171
Avalos AM, Valdivia AD, Muñoz N, Herrera-Molina R, Tapia JC, Lavandero S, Chiong M, Burridge K, Schneider P, Quest AFG, et al. 2009. Neuronal Thy-1 induces astrocyte adhesion by engaging syndecan-4 in a cooperative interaction with alphavbeta3 integrin that activates PKCalpha and RhoA. Journal of Cell Science. 122(Pt 19):3462-3471. https://doi.org/10.1242/jcs.034827
Uribe-San Martín R, Herrera-Molina R, Olavarría L, Ramírez G, von Bernhardi R. 2009. Reduction of β-amyloid-induced neurotoxicity on hippocampal cell cultures by moderate acidosis is mediated by transforming growth factor β. Neuroscience. 158(4):1338-1347. https://doi.org/10.1016/j.neuroscience.2008.11.002
Hermosilla T, Muñoz D, Herrera-Molina R, Valdivia A, Muñoz N, Nham S-U, Schneider P, Burridge K, Quest AFG, Leyton L. 2008. Direct Thy-1/alphaVbeta3 integrin interaction mediates neuron to astrocyte communication. Biochimica et biophysica acta. 1783(6):1111-1120. https://doi.org/10.1016/j.bbamcr.2008.01.034
Saud K, Herrera-Molina R, Von Bernhardi R. 2005. Pro- and anti-inflammatory cytokines regulate the ERK pathway: implication of the timing for the activation of microglial cells. Neurotoxicity research. 8(3-4):277-287. https://doi.org/10.1007/bf03033981
Herrera-Molina R, von Bernhardi R. 2005. Transforming growth factor-β1 produced by hippocampal cells modulates microglial reactivity in culture. Neurobiology of Disease. 19(1-2):229-236. https://doi.org/10.1016/j.nbd.2005.01.003
Third party funds
Third party funds
2020 - 2021 (LSA)
"Development of neuroplastin-derved TRAF6-binding peptides with a wide-range of anti-inflammatory properties"
2020 - 2021 (Sonstiges)
Förderprogramm PPP Kroatien 2020