LIN Staff

Prof. Dr. Stefan Remy

Managing Director

Cellular Neuroscience

Leibniz Institute for Neurobiology
Brenneckestr. 6
39118 Magdeburg
Germany
Phone: +49 391 6263 92421
Email: Stefan.Remy@lin-magdeburg.de
ORCID: 0000-0002-3386-1662

Publications
Publications
Barnstedt O, Mocellin P, Remy S. 2024. A hippocampus-accumbens code guides goal-directed appetitive behavior. Nature Communications. 15(1):Article 3196. https://doi.org/10.1038/s41467-024-47361-x
Mocellin P, Barnstedt O, Luxem K, Kaneko H, Vieweg S, Henschke JU, Dalügge D, Fuhrmann F, Karpova A, Pakan JMP, et al. 2024. A septal-ventral tegmental area circuit drives exploratory behavior. Neuron. 112(6):1020-1032.e7. https://doi.org/10.1016/j.neuron.2023.12.016
Li R, Huang J, Li L, Zhao Z, Liang S, Liang S, Wang M, Liao X, Lyu J, Zhou Z, et al. 2023. Holistic bursting cells store long-term memory in auditory cortex. Nature Communications. 14(1):Article 8090. https://doi.org/10.1038/s41467-023-43620-5
Mittag M, Mediavilla L, Remy S, Cuntz H, Jedlicka P. 2023. Modelling the contributions to hyperexcitability in a mouse model of Alzheimer's disease. Journal of Physiology. 601(15):3403-3437. https://doi.org/10.1113/JP283401
Jamaludeen N, Kuhn F, Brechmann A, Fuhrmann F, Remy S, Spiliopoulou M. 2023. Inferring Salient Motifs during Learning Experiments. Sicilia R, Kane B, Almeida JR, Spiliopoulou M, Andrades JAB, Placidi G, Gonzalez AR, editors. In Proceedings - 2023 IEEE 36th International Symposium on Computer-Based Medical Systems, CBMS 2023. IEEE. pp. 245-251. (Proceedings - IEEE Symposium on Computer-Based Medical Systems). https://doi.org/10.1109/CBMS58004.2023.00225
Ladd ME, Quick HH, Speck O, Bock M, Doerfler A, Forsting M, Hennig J, Ittermann B, Möller HE, Nagel AM, et al. 2023. Germany's journey toward 14 Tesla human magnetic resonance. Magnetic Resonance Materials in Physics, Biology, and Medicine. 36(2):191-210. https://doi.org/10.1007/s10334-023-01085-z
Li R, Huang J, Liang S, Liang S, Wang M, Liao X, Lyu J, Zhou Z, Jin W, Chen H, et al. 2023. Holistic Bursting Cells Store Long-term Memory in Auditory Cortex. Research Square. https://doi.org/10.21203/rs.3.rs-2665573/v1
Barnstedt O, Mocellin P, Remy S. 2023. A hippocampus-accumbens code guides goal-directed appetitive behavior. bioRxiv. https://doi.org/10.1101/2023.03.09.531869
Grochowska KM, Gomes GM, Raman R, Kaushik R, Sosulina L, Kaneko H, Oelschlegel AM, Yuanxiang P, Reyes-Resina I, Bayraktar G, et al. 2023. Jacob-induced transcriptional inactivation of CREB promotes Aβ-induced synapse loss in Alzheimer's disease. The EMBO journal. 42(4):Article e112453. https://doi.org/10.15252/embj.2022112453
Luxem K, Mocellin P, Fuhrmann F, Kürsch J, Miller SR, Palop JJ, Remy S, Bauer P. 2022. Identifying behavioral structure from deep variational embeddings of animal motion. Communications biology. 5(1):Article 1267. https://doi.org/10.1038/s42003-022-04080-7
Sosulina L, Mittag M, Geis H-R, Hoffmann K, Klyubin I, Qi Y, Steffen J, Friedrichs D, Henneberg N, Fuhrmann F, et al. 2021. Hippocampal hyperactivity in a rat model of Alzheimer's disease. Journal of Neurochemistry. 157(6):2128-2144. https://doi.org/10.1111/jnc.15323
Korvasová K, Ludwig F, Kaneko H, Sosulina L, Tetzlaff T, Remy S, Mikulovic S. 2021. Locomotion induced by medial septal glutamatergic neurons is linked to intrinsically generated persistent firing. bioRxiv. https://doi.org/10.1101/2021.04.23.441122
Bertan F, Wischhof L, Sosulina L, Mittag M, Dalügge D, Fornarelli A, Gardoni F, Marcello E, Di Luca M, Fuhrmann M, et al. 2020. Loss of Ryanodine Receptor 2 impairs neuronal activity-dependent remodeling of dendritic spines and triggers compensatory neuronal hyperexcitability. Cell Death and Differentiation. 27(12):3354-3373. https://doi.org/10.1038/s41418-020-0584-2
Schwarz MK, Remy S. 2019. Rabies virus-mediated connectivity tracing from single neurons. Journal of Neuroscience Methods. 325:108365. https://doi.org/10.1016/j.jneumeth.2019.108365
Dalügge D, Remy S. 2018. Human Cortical Dendrites: Stretched to Perform Better?. Cell. 175(3):635-637. https://doi.org/10.1016/j.cell.2018.09.052
Musial TF, Molina-Campos E, Bean LA, Ybarra N, Borenstein R, Russo ML, Buss EW, Justus D, Neuman KM, Ayala GD, et al. 2018. Store depletion-induced h-channel plasticity rescues a channelopathy linked to Alzheimer's disease. Neurobiology of Learning and Memory. 154:141-157. https://doi.org/10.1016/j.nlm.2018.06.004
Müller C, Remy S. 2018. Septo–hippocampal interaction. Cell and Tissue Research. 373(3):565-575. https://doi.org/10.1007/s00441-017-2745-2
Müller C, Geis HR, Remy S. 2018. Visually Guided Single-Cell Recordings in the Hippocampus of Awake Mice. Manahan-Vaughan D, editor. In Handbook of in Vivo Neural Plasticity Techniques. Elsevier. pp. 123-134. (Handbook of Behavioral Neuroscience). https://doi.org/10.1016/B978-0-12-812028-6.00006-9
Remy S, Poirazi P, Papoutsi A. 2017. Introduction to the Computational Neuroscience Special Section. European Journal of Neuroscience. 45(8):998-999. https://doi.org/10.1111/ejn.13562
Justus D, Dalügge D, Bothe S, Fuhrmann F, Hannes C, Kaneko H, Friedrichs D, Sosulina L, Schwarz I, Elliott DA, et al. 2017. Glutamatergic synaptic integration of locomotion speed via septoentorhinal projections. Nature Neuroscience. 20(1):16-19. https://doi.org/10.1038/nn.4447
Schmid LC, Mittag M, Poll S, Steffen J, Wagner J, Geis HR, Schwarz I, Schmidt B, Schwarz MK, Remy S, et al. 2016. Dysfunction of Somatostatin-Positive Interneurons Associated with Memory Deficits in an Alzheimer's Disease Model. Neuron. 92(1):114-125. https://doi.org/10.1016/j.neuron.2016.08.034
Müller C, Remy S. 2016. Slowly Building Excitement. Cell. 165(7):1568-1569. https://doi.org/10.1016/j.cell.2016.06.005
Wagner J, Krauss S, Shi S, Ryazanov S, Steffen J, Miklitz C, Leonov A, Kleinknecht A, Göricke B, Weishaupt JH, et al. 2015. Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies. Acta Neuropathologica. 130(5):619-631. https://doi.org/10.1007/s00401-015-1483-3
Fuhrmann F, Justus D, Sosulina L, Kaneko H, Beutel T, Friedrichs D, Schoch S, Schwarz MK, Fuhrmann M, Remy S. 2015. Locomotion, Theta Oscillations, and the Speed-Correlated Firing of Hippocampal Neurons Are Controlled by a Medial Septal Glutamatergic Circuit. Neuron. 86(5):1253-1264. https://doi.org/10.1016/j.neuron.2015.05.001
Qi Y, Klyubin I, Harney SC, Hu NW, Cullen WK, Grant MK, Steffen J, Wilson EN, Do Carmo S, Remy S, et al. 2014. Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aß-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: Rapid reversal by anti-Aß agents. Acta neuropathologica communications. 2(1):175. https://doi.org/10.1186/s40478-014-0175-x
Šišková Z, Justus D, Kaneko H, Friedrichs D, Henneberg N, Beutel T, Pitsch J, Schoch S, Becker A, vonderKammer H, et al. 2014. Dendritic structural degeneration is functionally linked to cellular hyperexcitability in a mouse model of alzheimer's disease. Neuron. 84(5):1023-1033. https://doi.org/10.1016/j.neuron.2014.10.024
Pothmann L, Müller C, Averkin RG, Bellistri E, Miklitz C, Uebachs M, Remy S, de la Prida LM, Beck H. 2014. Function of inhibitory micronetworks is spared by Na⁺ channel-acting anticonvulsant drugs. Journal of Neuroscience. 34(29):9720-9735. https://doi.org/10.1523/JNEUROSCI.2395-13.2014
Müller C, Remy S. 2014. Dendritic inhibition mediated by O-LM and bistratified interneurons in the hippocampus. Frontiers in Synaptic Neuroscience. 6(SEP):23. https://doi.org/10.3389/fnsyn.2014.00023
Müller C, Remy S. 2013. Fast micro-iontophoresis of glutamate and GABA: a useful tool to investigate synaptic integration. Journal of Visualized Experiments. (77). https://doi.org/10.3791/50701
Müller C, Beck H, Coulter D, Remy S. 2012. Inhibitory Control of Linear and Supralinear Dendritic Excitation in CA1 Pyramidal Neurons. Neuron. 75(5):851-864. https://doi.org/10.1016/j.neuron.2012.06.025
Krueppel R, Remy S, Beck H. 2011. Dendritic integration in hippocampal dentate granule cells. Neuron. 71(3):512-528. https://doi.org/10.1016/j.neuron.2011.05.043
Chen S, Su H, Yue C, Remy S, Royeck M, Sochivko D, Opitz T, Beck H, Yaari Y. 2011. An increase in persistent sodium current contributes to intrinsic neuronal bursting after status epilepticus. Journal of Neurophysiology. 105(1):117-129. https://doi.org/10.1152/jn.00184.2010
Park JY, Remy S, Varela J, Cooper DC, Chung S, Kang HW, Lee JH, Spruston N. 2010. A post-burst afterdepolarization is mediated by group I metabotropic glutamate receptor-dependent upregulation of Ca_v2.3 R-type calcium channels in CA1 pyramidal neurons. PLoS Biology. 8(11):e1000534. https://doi.org/10.1371/journal.pbio.1000534
Remy S, Beck H, Yaari Y. 2010. Plasticity of voltage-gated ion channels in pyramidal cell dendrites. Current Opinion in Neurobiology. 20(4):503-509. https://doi.org/10.1016/j.conb.2010.06.006
Remy S, Csicsvari J, Beck H. 2009. Activity-Dependent Control of Neuronal Output by Local and Global Dendritic Spike Attenuation. Neuron. 61(6):906-916. https://doi.org/10.1016/j.neuron.2009.01.032
Royeck M, Horstmann MT, Remy S, Reitze M, Yaari Y, Beck H. 2008. Role of axonal Na_V1.6 sodium channels in action potential initiation of CA1 pyramidal neurons. Journal of Neurophysiology. 100(4):2361-2380. https://doi.org/10.1152/jn.90332.2008
Remy S, Spruston N. 2007. Dendritic spikes induce single-burst long-term potentiation. Proceedings of the National Academy of Sciences of the United States of America. 104(43):17192-17197. https://doi.org/10.1073/pnas.0707919104
Remy S, Beck H. 2006. Molecular and cellular mechanisms of pharmacoresistance in epilepsy. Brain. 129(Pt 1):18-35. https://doi.org/10.1093/brain/awh682
Heinemann U, Kann O, Remy S, Beck H. 2006. Novel mechanisms underlying drug resistance in temporal lobe epilepsy.Advances in neurology. 97:85-95.
Yue C, Remy S, Su H, Beck H, Yaari Y. 2005. Proximal persistent Na⁺ channels drive spike afterdepolarizations and associated bursting in adult CA1 pyramidal cells. Journal of Neuroscience. 25(42):9704-9720. https://doi.org/10.1523/JNEUROSCI.1621-05.2005
Remy C, Remy S, Beck H, Swandulla D, Hans M. 2004. Modulation of voltage-dependent sodium channels by the δ-agonist SNC80 in acutely isolated rat hippocampal neurons. Neuropharmacology. 47(7):1102-1112. https://doi.org/10.1016/j.neuropharm.2004.06.034
Ellerkmann RK, Remy S, Chen J, Sochivko D, Elger CE, Urban BW, Becker A, Beck H. 2003. Molecular and functional changes in voltage-dependent Na⁺ channels following pilocarpine-induced status epilepticus in rat dentate granule cells. Neuroscience. 119(2):323-333. https://doi.org/10.1016/S0306-4522(03)00168-4
Remy S, Urban BW, Elger CE, Beck H. 2003. Anticonvulsant pharmacology of voltage-gated Na⁺ channels in hippocampal neurons of control and chronically epileptic rats. European Journal of Neuroscience. 17(12):2648-2658. https://doi.org/10.1046/j.1460-9568.2003.02710.x
Remy S, Gabriel S, Urban BW, Dietrich D, Lehmann TN, Elger CE, Heinemann U, Beck H. 2003. A novel mechanism underlying drug resistance in chronic epilepsy. Annals of Neurology. 53(4):469-479. https://doi.org/10.1002/ana.10473
Third party funds
Third party funds
2023 - 2027 (DFG)
SynAGE Teilprojekt C2 in Squad C: Synaptic insulin resistance at the basis of trajectories towards cognitive decline in high-risk ageing
2023 - 2027 (DFG)
SynAGE Teilprojekt D3.1 in Squad D: Synaptic changes and abberant memory-related network excitability in hippocampal-posterior cortical circuits with ageing
2023 - 2025 (Bund)
DZPG Aufbauförderung - "Standort Jena" - Physiologie und Pathophysiologie neuronaler Schaltkreise im Kontext psychischer Gesundheit
2022 - 2024 (LSA)
Exzellenz-Cluster Initiative, Kognitive Vitalität 1
2022 - 2024 (WGL)
Learning Resilience: Supporting neuronal network state transitions to foster stress resilience, Arbeitspaket 2 (self-balancing of cortical network states in stress recilience) und 3 (Brain-wide network state changes in cognitive flexibility behavioral fMRI)
2020 - 2024 (DFG)
SFB 1436 TP A03: Neurale Ressourcenallokation durch räumliche Gedächtnisschaltung im Hinblick auf fortschreitende pathologische Herausforderungen
https://sfb1436.de/
2022 - 2023 (LSA)
Anschubfinanzierung Deutsches Zentrum für Psychische Gesundheit - Magdeburg (DZPG-Land)
2020 - 2022 (EU)
SUBDECODE - Dendritic Dendritic encoding of movement in space 725693 - SUBDECODE - ERC-2016-COG
2020 - 2021 (DFG)
SFB 1089 TPB01: SFB 1089: Funktion synaptischer Mikronetzwerke und deren Störung bei Erkrankungen des Zentralnervensystems ,Teilprojekte B01 - Subkortikale Kontrolle neuronaler Aktivität im Hippokampus während der Lokomotion
2020 - 2021 (DFG)
SFB 1089/ TP C07: SFB 1089: Funktion synaptischer Mikronetzwerke und deren Störung bei Erkrankungen des Zentralnervensystems ,Teilprojekte C07 - Dendritische Mechanismen für Bildung von Merkmalselektivität in CA1 Neuronen und deren Beeinträchtigung bei Mausmodellen der Alzheimer-Krankheit