LIN Staff

Dr. Ulrich Thomas

Head of Working Group

Cellular Neuroscience

Leibniz Institute for Neurobiology
Brenneckestr. 6
39118 Magdeburg
Phone: +49 391 6263 93231
ORCID: 0000-0002-4372-8611

  • Publications


    Langnaese K, Tiwari N, Fischer K-D, Thomas U, Korthals M. 2024. Neuroplastin splice variants Np55 and Np65: Who is doing the job in macrophages?. Molecular immunology. 170:57-59.

    Bertin F, Jara-Wilde J, Auer B, Köhler-Solís A, González-Silva C, Thomas U, Sierralta J. 2023. Drosophila Atlastin regulates synaptic vesicle mobilization independent of bone morphogenetic protein signaling. Biological research. 56(1):Article 49.

    Ghelani T, Escher M, Thomas U, Esch K, Lützkendorf J, Depner H, Maglione M, Parutto P, Gratz S, Matkovic-Rachid T, et al. 2023. Interactive nanocluster compaction of the ELKS scaffold and Cacophony Ca2+ channels drives sustained active zone potentiation. Science advances. 9(7):Article eade7804.

    Beckmann D, Langnaese K, Gottfried A, Hradsky J, Tedford K, Tiwari N, Thomas U, Fischer K-D, Korthals M. 2023. Ca2+ Homeostasis by Plasma Membrane Ca2+ ATPase (PMCA) 1 Is Essential for the Development of DP Thymocytes. International Journal of Molecular Sciences. 24(2):Article 1442.

    Kobler O, Weiglein A, Hartung K, Chen Y-C, Gerber B, Thomas U. 2021. A quick and versatile protocol for the 3D visualization of transgene expression across the whole body of larval Drosophila. Journal of Neurogenetics. 35(3):306-319.

    Krick N, Ryglewski S, Pichler A, Bikbaev A, Götz T, Kobler O, Heine M, Thomas U, Duch C. 2021. Separation of presynaptic Cav2 and Cav1 channel function in synaptic vesicle exo- and endocytosis by the membrane anchored Ca2+ pump PMCA. Proceedings of the National Academy of Sciences of the United States of America. 118(28):Article e2106621118.

    Korthals M, Tech L, Langnaese K, Gottfried A, Hradsky J, Thomas U, Zenclussen AC, Brunner-Weinzierl MC, Tedford K, Fischer KD. 2021. Plasma membrane Ca2+ ATPase 1 (PMCA1) but not PMCA4 is critical for B-cell development and Ca2+ homeostasis in mice. European Journal of Immunology. 51(3):594-602.

    Meltendorf S, Fu H, Pierau M, Lindquist JA, Finzel S, Mertens PR, Gieseler-Halbach S, Ambach A, Thomas U, Lingel H, et al. 2020. Cell Survival Failure in Effector T Cells From Patients With Systemic Lupus Erythematosus Following Insufficient Up-Regulation of Cold-Shock Y-Box Binding Protein 1. Arthritis & rheumatology (Hoboken, N.J.). 72(10):1721-1733.

    Schattling B, Engler JB, Volkmann C, Rothammer N, Woo MS, Petersen M, Winkler I, Kaufmann M, Rosenkranz SC, Fejtova A, et al. 2019. Bassoon proteinopathy drives neurodegeneration in multiple sclerosis. Nature Neuroscience. 22(6):887-896.

    Marter K, Kobler O, Erdmann I, Soleimanpour E, Landgraf P, Mueller A, Abele J, Thomas U, Dieterich D. 2019. Click Chemistry (CuAAC) and Detection of Tagged de novo Synthesized Proteins in Drosophila. Bio-protocol. 9(2):Article e3142.

    Wu S, Gan G, Zhang Z, Sun J, Wang Q, Gao Z, Li M, Jin S, Huang J, Thomas U, et al. 2017. A presynaptic function of shank protein in Drosophila. Journal of Neuroscience. 37(48):11592-11604.

    Korthals M, Langnaese K, Smalla KH, Kähne T, Herrera-Molina R, Handschuh J, Lehmann AC, Mamula D, Naumann M, Seidenbecher C, et al. 2017. A complex of Neuroplastin and Plasma Membrane Ca2+ ATPase controls T cell activation. Scientific Reports. 7(1):Article 8358.

    Erdmann I, Marter K, Kobler O, Niehues S, Mueller A, Abele J, Storkebaum E, Thomas U, Dieterich D. 2017. Cell Type-specific Metabolic Labeling of Proteins with Azidonorleucine in Drosophila. Bio-protocol. 7(14).

    Gieseler-Halbach S, Meltendorf S, Pierau M, Weinert S, Heidel FH, Fischer T, Handschuh J, Braun-Dullaeus RC, Schrappe M, Lindquist JA, et al. 2017. RSK-mediated nuclear accumulation of the cold-shock Y-box protein-1 controls proliferation of T cells and T-ALL blasts. Cell Death and Differentiation. 24(2):371-383.

    Voigt A, Freund R, Heck J, Missler M, Obermair GJ, Thomas U, Heine M. 2016. Dynamic association of calcium channel subunits at the cellular membrane. Neurophotonics. 3(4):Article 041809.

    Erdmann I, Marter K, Kobler O, Niehues S, Abele J, Müller A, Bussmann J, Storkebaum E, Ziv T, Thomas U, et al. 2015. Cell-selective labelling of proteomes in Drosophila melanogaster. Nature Communications. 6:Article 7521.

    Niehues S, Bussmann J, Steffes G, Erdmann I, Köhrer C, Sun L, Wagner M, Schäfer K, Wang G, Koerdt SN, et al. 2015. Impaired protein translation in Drosophila models for Charcot-Marie-Tooth neuropathy caused by mutant tRNA synthetases. Nature Communications. 6:Article 7520.

    Schneider R, Hosy E, Kohl J, Klueva J, Choquet D, Thomas U, Voigt A, Heine M. 2015. Mobility of Calcium Channels in the Presynaptic Membrane. Neuron. 86(3):672-679.

    Koch N, Kobler O, Thomas U, Qualmann B, Kessels MM. 2014. Terminal axonal arborization and synaptic bouton formation critically rely on Abp1 and the Arp2/3 complex. PLoS ONE. 9(5):Article e97692.

    Korthals M, Schilling K, Reichardt P, Mamula D, Schlüter T, Steiner M, Langnäse K, Thomas U, Gundelfinger E, Premont RT, et al. 2014. αpIX RhoGEF supports positive selection by restraining migration and promoting arrest of thymocytes. Journal of Immunology. 192(7):3228-3238.

    Matkovic T, Siebert M, Knoche E, Depner H, Mertel S, Owald D, Schmidt M, Thomas U, Sickmann A, Kamin D, et al. 2013. The bruchpilot cytomatrix determines the size of the readily releasable pool of synaptic vesicles. Journal of Cell Biology. 202(4):667-683.

    Koch N, Dharmalingam E, Westermann M, Qualmann B, Thomas U, Kessels MM. 2012. Abp1 utilizes the Arp2/3 complex activator Scar/WAVE in bristle development. Journal of Cell Science. 125(Pt 15):3578-3589.

    Chen Y, Yuanxiang P, Knöpfel T, Thomas U, Behnisch T. 2012. Hippocampal LTP triggers proteasome-mediated SPAR degradation in CA1 neurons. Synapse. 66(2):142-150.

    Thomas U, Sigrist SJ. 2012. Glutamate receptors in synaptic assembly and plasticity: Case studies on fly NMJs. In Advances in Experimental Medicine and Biology. pp. 3-28. (Advances in Experimental Medicine and Biology).

    Thomas U, Kobler O, Gundelfinger ED. 2010. The Drosophila larval neuromuscular junction as a model for scaffold complexes at glutamatergic synapses: Benefits and limitations. Journal of Neurogenetics. 24(3):109-119.

    Bachmann A, Kobler O, Kittel RJ, Wichmann C, Sierralta J, Sigrist SJ, Gundelfinger ED, Knust E, Thomas U. 2010. A perisynaptic ménage à trois between Dlg, DLin-7, and metro controls proper organization of Drosophila synaptic junctions. Journal of Neuroscience. 30(17):5811-5824.

    Saavedra MV, Smalla KH, Thomas U, Sandoval S, Olavarria K, Castillo K, Delgado MG, Delgado R, Gundelfinger ED, Bacigalupo J, et al. 2008. Scaffolding proteins in highly purified rat olfactory cilia membranes. NeuroReport. 19(11):1123-1126.

    Mendoza-Topaz C, Urra F, Barría R, Albornoz V, Ugalde D, Thomas U, Gundelfinger ED, Delgado R, Kukuljan M, Sanxaridis PD, et al. 2008. DLGS97/SAP97 is developmentally upregulated and is required for complex adult behaviors and synapse morphology and function. Journal of Neuroscience. 28(1):304-314.

    Sandoval M, Sandoval R, Thomas U, Spilker C, Smalla KH, Falcon R, Marengo JJ, Calderón R, Saavedra V, Heumann R, et al. 2007. Antagonistic effects of TrkB and p75NTR on NMDA receptor currents in post-synaptic densities transplanted into Xenopus oocytes. Journal of Neurochemistry. 101(6):1672-1684.

    Wasserscheid I, Thomas U, Knust E. 2007. Isoform-specific interaction of flamingo/starry night with excess Bazooka affects planar cell polarity in the Drosophila wing. Developmental Dynamics. 236(4):1064-1071.

    Langnäse K, Richter K, Smalla KH, Krauss M, Thomas U, Wolf G, Laube G. 2007. Splice-isoform specific immunolocalization of neuronal nitric oxide synthase in mouse and rat brain reveals that the PDZ-complex-building nNOSα β-finger is largely exposed to antibodies. Developmental Neurobiology. 67(4):422-437.

    Gorczyca D, Ashley J, Speese S, Gherbesi N, Thomas U, Gundelfinger E, Gramates LS, Budnik V. 2007. Postsynaptic membrane addition depends on the discs-large-interacting t-SNARE Gtaxin. Journal of Neuroscience. 27(5):1033-1044.

    Swan LE, Schmidt M, Schwarz T, Ponimaskin E, Prange U, Boeckers T, Thomas U, Sigrist SJ. 2006. Complex interaction of Drosophila GRIP PDZ domains and Echinoid during muscle morphogenesis. EMBO Journal. 25(15):3640-3651.

    Dirks P, Thomas U, Montag D. 2006. The cytoplasmic domain of NrCAM binds to PDZ domains of synapse-associated proteins SAP90/PSD95 and SAP97. European Journal of Neuroscience. 24(1):25-31.

    Karpova A, Mikhaylova M, Thomas U, Knöpfel T, Behnisch T. 2006. Involvement of protein synthesis and degradation in long-term potentiation of Schaffer collateral CA1 synapses. Journal of Neuroscience. 26(18):4949-4955.

    Ataman B, Budnik V, Thomas U. 2006. Scaffolding Proteins at the Drosophila Neuromuscular Junction. International Review of Neurobiology. 75:181-216.

    Bachmann A, Timmer M, Sierralta J, Pietrini G, Gundelfinger ED, Knust E, Thomas U. 2004. Cell type-specific recruitment of Drosophila Lin-7 to distinct MAGUK-based protein complexes defines novel roles for Sdt and Dlg-S97. Journal of Cell Science. 117(Pt 10):1899-1909.

    Mendoza C, Olguín P, Lafferte G, Thomas U, Ebitsch S, Gundelfinger ED, Kukuljan M, Sierralta J. 2003. Novel isoforms of dlg are fundamental for neuronal development in Drosophila. Journal of Neuroscience. 23(6):2093-2101.

    Thomas U. 2002. Modulation of synaptic signalling complexes by Homer proteins. Journal of Neurochemistry. 81(3):407-413.

    Mathew D, Gramates LS, Packard M, Thomas U, Bilder D, Perrimon N, Gorczyca M, Budnik V. 2002. Recruitment of Scribble to the synaptic scaffolding complex requires GUK-holder, a novel DLG binding protein. Current Biology. 12(7):531-539.

    Diagana TT, Thomas U, Prokopenko SN, Xiao B, Worley PF, Thomas JB. 2002. Mutation of Drosophila homer disrupts control of locomotor activity and behavioral plasticity. Journal of Neuroscience. 22(2):428-436.

    Chamaon K, Smalla KH, Thomas U, Gundelfinger ED. 2002. Nicotinic acetylcholine receptors of Drosophila: Three subunits encoded by genomically linked genes can co-assemble into the same receptor complex. Journal of Neurochemistry. 80(1):149-157.

    Thomas U, Ebitsch S, Gorczyca M, Koh YH, Hough CD, Woods D, Gundelfinger ED, Budnik V. 2000. Synaptic targeting and localization of Discs-large is a stepwise process controlled by different domains of the protein. Current Biology. 10(18):1108-1117.

    Thomas U, Kim E, Kuhlendahl S, Koh YH, Gundelfinger ED, Sheng M, Garner CC, Budnik V. 1997. Synaptic clustering of the cell adhesion molecule Fasciclin II by discs- large and its role in the regulation of presynaptic structure. Neuron. 19(4):787-799.

    Thomas U, Phannavong B, Müller B, Garner CC, Gundelfinger ED. 1997. Functional expression of rat synapse-associated proteins SAP97 and SAP102 in Drosophila dlg-1 mutants: Effects on tumor suppression and synaptic bouton structure. Mechanisms of Development. 62(2):161-174.

    Thomas U, Jönsson F, Speicher SA, Knust E. 1995. Phenotypic and molecular characterization of SerD, a dominant allele of the Drosophila gene Serrate. Genetics. 139(1):203-213.

    Speicher SA, Thomas U, Hinz U, Knust E. 1994. The Serrate locus of Drosophila and its role in morphogenesis of the wing imaginal discs: Control of cell proliferation. Development (Cambridge). 120(3):535-544.
  • Third party funds

    Third party funds

    2010 - 2022 (DFG)
    SFB 854/ TP 08: Bedeutung prototypischer Gerüstproteine und ihrer Interaktionen für Assembly und Funktion Immunologischer Synapsen

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