Department Neurochemistry & Molecular Biology

How do nerve cells in the brain communicate? How are they connected and what happens if they are wrongly wired? How is decided which information is stored and which is forgotten? How do nerve cells keep fit and what happens when they age? Our research is dedicated to such and similar questions.

The communication between nerve cells takes place at microscopically small connections, the synapses. During the interconnection of the brain, synapses have to develop, then they have to be kept functional and, for example, have to be rebuilt in the course of learning and memory processes. These processes involve many molecules in the neurons, on their surface and in the extracellular matrix surrounding them. The various closely cooperating research groups in the department are investigating the function of synapses, their molecular composition and plasticity under normal physiological conditions and in cases of disease-related malfunction.

  • Head


    Eckart D. Gundelfinger (PhD) is the head of the department and since 2010 acts as managing scientific director of the LIN. He is also appointed as Professor of Molecular Neurobiology at the Otto von Guericke University, Medical Faculty in Magdeburg and one of the spokespersons of the Center for Behavioral Brain Sciences (CBBS) Magdeburg. He studied Biology at the University of Stuttgart, performed research for his doctoral thesis at the May Planck Institute for Biology in Tübingen and spent two years as postdoctoral EMBO fellow at the EMBL in Heidelberg. In 1984, he started his research on molecular mechanisms of brain synapses, first as a staff scientist at the Center for Molecular Biology of the University of Heidelberg (ZMBH, with Heinrich Betz) and from 1988 in his own group at the Center for Molecular Neurobiology in Hamburg (ZMNH). Since 1992 he heads the Dept. of Neurochemistry and Molecular Biology at the LIN. Current research is focused on molecular mechanisms of synaptic plasticity underlying learning and memory and on disease mechanisms of synapthopathies.

  • Members


    Gundelfinger, Prof. Dr. Eckart D. +49-391-6263-92421,
    Bartsch, Maren +49-391-6263-93311,
    Head of Working Groups  
    Dr. Rodrigo
    Prof. Dr. Constanze
    Dr. Ulrich
    Dr. Anil
    Dr. Carolina
    Dr. Rainer
    PhD students  
    Lennart Junge (cand. med.)
    Jessica Mitlö
    Nikhil Tiwari
    Technical staff members  
    Kathrin Gruß
    Kathrin Pohlmann+49-391-6263-93251,
    Associated members  
    Dr. Renato Frischknecht
    Klaus Reymann, Emeritus (seit 02/2017)  


  • Projects


    Brain features including learning and memory are based on the performance of chemical synapses, i.e., their dynamics and their various forms of plasticity. Research in the department is concerned with molecular and cellular mechanisms of synaptic plasticity in health and disease. Key research topics are…

  • Current Third Party Funds

    Current Third Party Funds

    DFG SFB 779 "Neurobiology of Motivated Behavior"

    DFG SFB 854 "Molecular organisation of cellular communication within the immune system"

    European Commission "Innovative Training Network ECMED"

    DFG GRK 2413 SynAGE

    "The aging synapse - molecular, cellular and behavioural mechanisms of cognitive decline in performance"

    BMBF-FONDECYT/Chile "PrePlastic"

    European Commission / ESF "Graduate School ABINEP"

    China Scholarship Council (CSC), PhD fellowship

    Leibniz-SAS, CBBS-ScienceCampus

  • Publications



    Schott BH, Wüstenberg T, Lücke E, Pohl IM, Richter A, Seidenbecher CI, Pollmann S, Kizilirmak JM, Richardson-Klavehn A. 2019. Gradual acquisition of visuospatial associative memory representations via the dorsal precuneus. Human Brain Mapping. 40(5):1554-1570.

    Ilic K, Auer B, Mlinac-Jerkovic K, Herrera-Molina R. 2019. Neuronal Signaling by Thy-1 in Nanodomains With Specific Ganglioside Composition: Shall We Open the Door to a New Complexity?. Frontiers in Cell and Developmental Biology. 7.



    Lira M, Arancibia D, Orrego PR, Montenegro-Venegas C, Cruz Y, García J, Leal-Ortiz S, Godoy JA, Gundelfinger ED, Inestrosa NC, Garner CC, Zamorano P, Torres VI. 2018. The Exocyst Component Exo70 Modulates Dendrite Arbor Formation, Synapse Density, and Spine Maturation in Primary Hippocampal Neurons. Molecular Neurobiology.

    Bruna B, Lobos P, Herrera-Molina R, Hidalgo C, Paula-Lima A, Adasme T. 2018. The signaling pathways underlying BDNF-induced Nrf2 hippocampal nuclear translocation involve ROS, RyR-Mediated Ca2+ signals, ERK and PI3K. Biochemical and Biophysical Research Communications. 505(1):201-207.

    Annamneedi A, Caliskan G, Müller S, Montag D, Budinger E, Angenstein F, Fejtova A, Tischmeyer W, Gundelfinger ED, Stork O. 2018. Ablation of the presynaptic organizer Bassoon in excitatory neurons retards dentate gyrus maturation and enhances learning performance. Brain Structure and Function. 223(7):3423-3445.

    Lang D, Schott BH, van Ham M, Morton L, Kulikovskaja L, Herrera-Molina R, Pielot R, Klawonn F, Montag D, Jänsch L, Gundelfinger ED, Smalla KH, Dunay IR. 2018. Chronic Toxoplasma infection is associated with distinct alterations in the synaptic protein composition. Journal of Neuroinflammation. 15(1):216.

    Pandya NJ, Seeger C, Babai N, Gonzalez-Lozano MA, Mack V, Lodder JC, Gouwenberg Y, Mansvelder HD, Danielson UH, Li KW, Heine M, Spijker S, Frischknecht R, Smit AB. 2018. Noelin1 Affects Lateral Mobility of Synaptic AMPA Receptors. Cell Reports. 24(5):1218-1230.

    Lagos-Cabré R, Brenet M, Díaz J, Pérez RD, Pérez LA, Herrera-Molina R, Quest AFG, Leyton L. 2018. Intracellular ca2+ increases and connexin 43 hemichannel opening are necessary but not sufficient for thy-1-induced astrocyte migration. International Journal of Molecular Sciences. 19(8).

    Colic L, Li M, Demenescu LR, Li S, Müller I, Richter A, Behnisch G, Seidenbecher CI, Speck O, Schott BH, Stork O, Walter M. 2018. GAD65 promoter polymorphism rs2236418 modulates harm avoidance in women via inhibition/excitation balance in the rostral ACC. Journal of Neuroscience. 38(22):5067-5077.



    Wu S, Gan G, Zhang Z, Sun J, Wang Q, Gao Z, Li M, Jin S, Huang J, Thomas U, Jiang YH, Li Y, Tian R, Zhang YQ. 2017. A presynaptic function of shank protein in Drosophila. Journal of Neuroscience. 37(48):11592-11604. Available from: 10.1523/JNEUROSCI.0893-17.2017

    Lagos-Cabré R, Alvarez A, Kong M, Burgos-Bravo F, Cárdenas A, Rojas-Mancilla E, Pérez-Nuñez R, Herrera-Molina R, Rojas F, Schneider P, Herrera-Marschitz M, Quest AFG, van Zundert B, Leyton L. 2017. αVβ3 Integrin regulates astrocyte reactivity. Journal of Neuroinflammation. 14(1). Available from: 10.1186/s12974-017-0968-5

    Schweitzer B, Singh J, Fejtova A, Groc L, Heine M, Frischknecht R. 2017. Hyaluronic acid based extracellular matrix regulates surface expression of GluN2B containing NMDA receptors. Scientific Reports. 7(1). Available from: 10.1038/s41598-017-07003-3

    Korthals M, Langnaese K, Smalla KH, Kähne T, Herrera-Molina R, Handschuh J, Lehmann AC, Mamula D, Naumann M, Seidenbecher C, Zuschratter W, Tedford K, Gundelfinger ED, Montag D, Fischer KD, Thomas U. 2017. A complex of Neuroplastin and Plasma Membrane Ca2+ ATPase controls T cell activation. Scientific Reports. 7(1). Available from: 10.1038/s41598-017-08519-4

    Herrera-Molina R, Mlinac-Jerkovic K, Ilic K, Stöber F, Vemula SK, Sandoval M, Milosevic NJ, Simic G, Smalla KH, Goldschmidt J, Bognar SK, Montag D. 2017. Neuroplastin deletion in glutamatergic neurons impairs selective brain functions and calcium regulation: Implication for cognitive deterioration. Scientific Reports. 7(1). Available from: 10.1038/s41598-017-07839-9

    Lazarevic V, Fieńko S, Andres-Alonso M, Anni D, Ivanova D, Montenegro-Venegas C, Gundelfinger ED, Cousin MA, Fejtova A. 2017. Physiological concentrations of amyloid beta regulate recycling of synaptic vesicles via alpha7 acetylcholine receptor and CDK5/calcineurin signaling. Frontiers in Molecular Neuroscience. 10. Available from: 10.3389/fnmol.2017.00221

    Kawabe H, Mitkovski M, Kaeser PS, Hirrlinger J, Opazo F, Nestvogel D, Kalla S, Fejtova A, Verrier SE, Bungers SR, Cooper BH, Varoqueaux F, Wang Y, Nehring RB, Gundelfinger ED, Rosenmund C, Rizzoli SO, Südhof TC, Rhee J-S, Brose N. 2017. ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones. Journal of Cell Biology. 216(4):1143-1161. Available from: 10.1083/jcb.201606086

    Altmüller F, Pothula S, Annamneedi A, Nakhei-Rad S, Montenegro-Venegas C, Pina-Fernández E, Marini C, Santos M, Schanze D, Montag D, Ahmadian MR, Stork O, Zenker M, Fejtova A. 2017. Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy. PLoS Genetics. 13(3). Available from: 10.1371/journal.pgen.1006684

    Okerlund ND, Schneider K, Leal-Ortiz SA, Montenegro-Venegas C, Kim SA, Garner LC, Gundelfinger ED, Reimer RJ, Garner CC. 2017. Bassoon Controls Presynaptic Autophagy through Atg5. Neuron. 93(4):897-913.e7. Available from: 10.1016/j.neuron.2017.01.026

    Maldonado H, Calderon C, Burgos-Bravo F, Kobler O, Zuschratter W, Ramirez O, Härtel S, Schneider P, Quest AFG, Herrera-Molina R, Leyton L. 2017. Astrocyte-to-neuron communication through integrin-engaged Thy-1/CBP/Csk/Src complex triggers neurite retraction via the RhoA/ROCK pathway. Biochimica et Biophysica Acta - Molecular Cell Research. 1864(2):243-254. Available from: 10.1016/j.bbamcr.2016.11.006

    Bhattacharya S, Herrera-Molina R, Sabanov V, Ahmed T, Iscru E, Stöber F, Richter K, Fischer KD, Angenstein F, Goldschmidt J, Beesley PW, Balschun D, Smalla KH, Gundelfinger ED, Montag D. 2017. Genetically induced retrograde amnesia of associative memories after neuroplastin ablation. Biological Psychiatry. 81(2):124-135. Available from: 10.1016/j.biopsych.2016.03.2107

    Gieseler-Halbach S, Meltendorf S, Pierau M, Weinert S, Heidel FH, Fischer T, Handschuh J, Braun-Dullaeus RC, Schrappe M, Lindquist JA, Mertens PR, Thomas U, Brunner-Weinzierl MC. 2017. RSK-mediated nuclear accumulation of the cold-shock Y-box protein-1 controls proliferation of T cells and T-ALL blasts. Cell Death and Differentiation. 24(2):371-383. Available from: 10.1038/cdd.2016.141



    Kolodziej A, Smalla KH, Richter S, Engler A, Pielot R, Dieterich DC, Tischmeyer W, Naumann M, Kähne T. 2016. High resolution quantitative synaptic proteome profiling of mouse brain regions after auditory discrimination learning. Journal of Visualized Experiments. 2016(118). Available from: 10.3791/54992

    Terry-Lorenzo RT, Torres VI, Wagh D, Galaz J, Swanson SK, Florens L, Washburn MP, Waites CL, Gundelfinger ED, Reimer RJ, Garner CC. 2016. Trio, a rho family GEF, interacts with the presynaptic active zone proteins piccolo and bassoon. PLoS ONE. 11(12). Available from: 10.1371/journal.pone.0167535

    Ivanova D, Dirks A, Fejtova A. 2016. Bassoon and piccolo regulate ubiquitination and link presynaptic molecular dynamics with activity-regulated gene expression. Journal of Physiology. 594(19):5441-5448. Available from: 10.1113/JP271826

    Voigt A, Freund R, Heck J, Missler M, Obermair GJ, Thomas U, Heine M. 2016. Dynamic association of calcium channel subunits at the cellular membrane. Neurophotonics. 3(4). Available from: 10.1117/1.NPh.3.4.041809

    Lepeta K, Lourenco MV, Schweitzer BC, Martino Adami PV, Banerjee P, Catuara-Solarz S, de La Fuente Revenga M, Guillem AM, Haidar M, Ijomone OM, Nadorp B, Qi L, Perera ND, Refsgaard LK, Reid KM, Sabbar M, Sahoo A, Schaefer N, Sheean RK, Suska A, Verma R, Vicidomini C, Wright D, Zhang XD, Seidenbecher C. 2016. Synaptopathies: synaptic dysfunction in neurological disorders – A review from students to students. Journal of Neurochemistry. 785-805. Available from: 10.1111/jnc.13713

    Bodaleo FJ, Montenegro-Venegas C, Henríquez DR, Court FA, Gonzalez-Billault C. 2016. Microtubule-associated protein 1B (MAP1B)-deficient neurons show structural presynaptic deficiencies in vitro and altered presynaptic physiology. Scientific Reports. 6. Available from: 10.1038/srep30069

    Kähne T, Richter S, Kolodziej A, Smalla KH, Pielot R, Engler A, Ohl FW, Dieterich DC, Seidenbecher C, Tischmeyer W, Naumann M, Gundelfinger ED. 2016. Proteome rearrangements after auditory learning: high-resolution profiling of synapse-enriched protein fractions from mouse brain. Journal of Neurochemistry. 124-138. Available from: 10.1111/jnc.13636

    Lubbers BR, Matos MR, Horn A, Visser E, Van Der Loo RC, Gouwenberg Y, Meerhoff GF, Frischknecht R, Seidenbecher CI, Smit AB, Spijker S, Van Den Oever MC. 2016. The Extracellular Matrix Protein Brevican Limits Time-Dependent Enhancement of Cocaine Conditioned Place Preference. Neuropsychopharmacology. 41(7):1907-1916. Available from: 10.1038/npp.2015.361

    Möhle L, Israel N, Paarmann K, Krohn M, Pietkiewicz S, Müller A, Lavrik IN, Buguliskis JS, Schott BH, Schlüter D, Gundelfinger ED, Montag D, Seifert U, Pahnke J, Dunay IR. 2016. Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes. Acta neuropathologica communications. 4:25. Available from: 10.1186/s40478-016-0293-8

    Frischknecht R, Happel MFK. 2016. Einfluss der Extrazellulären Matrix auf plastische Prozesse in jungen und alten Gehirnen: Extrazelluläre Matrix und Hirnplastizität. Neuroforum. 22(1):1-9. Available from: 10.1007/S12269-015-0033-1

    Mikhaylova M, Bera S, Kobler O, Frischknecht R, Kreutz MR. 2016. A Dendritic Golgi Satellite between ERGIC and Retromer. Cell Reports. 14(2):189-199. Available from: 10.1016/j.celrep.2015.12.024

    Gundelfinger ED, Reissner C, Garner CC. 2016. Role of Bassoon and Piccolo in Assembly and Molecular Organization of the Active Zone. Frontiers in Synaptic Neuroscience. 7:19. Available from: 10.3389/fnsyn.2015.00019



    Barman A, Richter S, Soch J, Deibele A, Richter A, Assmann A, Wüstenberg T, Walter H, Seidenbecher CI, Schott BH. 2015. Gender-specific modulation of neural mechanisms underlying social reward processing by Autism Quotient. Social Cognitive and Affective Neuroscience. 10(11):1537-1547. Available from: 10.1093/scan/nsv044

    Blosa M, Sonntag M, Jäger C, Weigel S, Seeger J, Frischknecht R, Seidenbecher CI, Matthews RT, Arendt T, Rübsamen R, Morawski M. 2015. The extracellular matrix molecule brevican is an integral component of the machinery mediating fast synaptic transmission at the calyx of Held. Journal of Physiology. 593(19):4341-4360. Available from: 10.1113/JP270849

    Bikbaev A, Frischknecht R, Heine M. 2015. Brain extracellular matrix retains connectivity in neuronal networks. Scientific Reports. 5. Available from: 10.1038/srep14527

    Giniatullina A, Maroteaux G, Geerts CJ, Koopmans B, Loos M, Klaassen R, Chen N, van der Schors RC, van Nierop P, Li KW, de Jong J, Altrock WD, Cornelisse LN, Toonen RF, van der Sluis S, Sullivan PF, Stiedl O, Posthuma D, Smit AB, Groffen AJ, Verhage M. 2015. Functional characterization of the PCLO p.Ser4814Ala variant associated with major depressive disorder reveals cellular but not behavioral differences. Neuroscience. 300:518-538. Available from: 10.1016/j.neuroscience.2015.05.047

    Erdmann I, Marter K, Kobler O, Niehues S, Abele J, Müller A, Bussmann J, Storkebaum E, Ziv T, Thomas U, Dieterich DC. 2015. Cell-selective labelling of proteomes in Drosophila melanogaster. Nature Communications. 6. Available from: 10.1038/ncomms8521

    Niehues S, Bussmann J, Steffes G, Erdmann I, Köhrer C, Sun L, Wagner M, Schäfer K, Wang G, Koerdt SN, Stum M, RajBhandary UL, Thomas U, Aberle H, Burgess RW, Yang XL, Dieterich D, Storkebaum E. 2015. Impaired protein translation in Drosophila models for Charcot-Marie-Tooth neuropathy caused by mutant tRNA synthetases. Nature Communications. 6. Available from: 10.1038/ncomms8520

    Schneider R, Hosy E, Kohl J, Klueva J, Choquet D, Thomas U, Voigt A, Heine M. 2015. Mobility of Calcium Channels in the Presynaptic Membrane. Neuron. 86(3):672-680. Available from: 10.1016/j.neuron.2015.03.050

    Ivanova D, Dirks A, Montenegro-Venegas C, Schöne C, Altrock WD, Marini C, Frischknecht R, Schanze D, Zenker M, Gundelfinger ED, Fejtova A. 2015. Synaptic activity controls localization and function of CtBP1 via binding to Bassoon and Piccolo. EMBO Journal. 34(8):1056-1077. Available from: 10.15252/embj.201488796

    Reichenbach N, Herrmann U, Kähne T, Schicknick H, Pielot R, Naumann M, Dieterich DC, Gundelfinger ED, Smalla KH, Tischmeyer W. 2015. Differential effects of dopamine signalling on long-term memory formation and consolidation in rodent brain. Proteome Science. 13(1). Available from: 10.1186/s12953-015-0069-2

    Pielot R, Kohl S, Manz B, Rutten T, Weier D, Tarkowská D, Rolčík J, Strnad M, Volke F, Weber H, Weschke W. 2015. Hormone-mediated growth dynamics of the barley pericarp as revealed by magnetic resonance imaging and transcript profiling. Journal of Experimental Botany. 66(21):6927-6943. Available from: 10.1093/jxb/erv397



    Rosenberg T, Gal-Ben-Ari S, Dieterich DC, Kreutz MR, Ziv NE, Gundelfinger ED, Rosenblum K. 2014. The roles of protein expression in synaptic plasticity and memory consolidation. Frontiers in Molecular Neuroscience. 7(November). Available from: 10.3389/fnmol.2014.00086

    Beesley PW, Herrera-Molina R, Smalla KH, Seidenbecher C. 2014. The Neuroplastin adhesion molecules: key regulators of neuronal plasticity and synaptic function. Journal of Neurochemistry. 131(3):268-283. Available from: 10.1111/jnc.12816

    Valenzuela Macaya JC, Heise C, Franken G, Singh J, Schweitzer B, Seidenbecher CI, Frischknecht R. 2014. Hyaluronan-based extracellular matrix under conditions of homeostatic plasticity. Philosophical Transactions of the Royal Society B: Biological Sciences. 369(1654). Available from: 10.1098/rstb.2013.0606

    Klueva J, Gundelfinger ED, Frischknecht RR, Heine M. 2014. Intracellular ca2+ and not the extracellular matrix determines surface dynamics of AMPA-type glutamate receptors on aspiny neurons. Philosophical Transactions of the Royal Society B: Biological Sciences. 369(1654). Available from: 10.1098/rstb.2013.0605

    Richter A, Guitart-Masip M, Barman A, Libeau C, Behnisch G, Czerney S, Schanze D, Assmann A, Klein M, Düzel E, Zenker M, Seidenbecher CI, Schott BH. 2014. Valenced action/inhibition learning in humans is modulated by a genetic variant linked to dopamine D2 receptor expression. Frontiers in Systems Neuroscience. 8(AUG). Available from: 10.3389/fnsys.2014.00140

    Koch N, Kobler O, Thomas U, Qualmann B, Kessels MM. 2014. Terminal axonal arborization and synaptic bouton formation critically rely on Abp1 and the Arp2/3 complex. PLoS ONE. 9(5). Available from: 10.1371/journal.pone.0097692

    Davydova D, Marini C, King C, Klueva J, Bischof F, Romorini S, Montenegro-Venegas C, Heine M, Schneider R, Schroeder M, Altrock WD, Henneberger C, Rusakov DA, Gundelfinger ED, Fejtova A. 2014. Bassoon specifically controls presynaptic P/Q-type Ca2+ channels via RIM-binding protein. Neuron. 82(1):181-194. Available from: 10.1016/j.neuron.2014.02.012

    Korthals M, Schilling K, Reichardt P, Mamula D, Schlüter T, Steiner M, Langnäse K, Thomas U, Gundelfinger E, Premont RT, Tedford K, Fischer KD. 2014. αpIX RhoGEF supports positive selection by restraining migration and promoting arrest of thymocytes. Journal of Immunology. 192(7):3228-3238. Available from: 10.4049/jimmunol.1302585

    Herrera Molina R, Sarto-Jackson I, Montenegro-Venegas C, Heine M, Smalla KH, Seidenbecher CI, Beesley PW, Gundelfinger ED, Montag D. 2014. Structure of excitatory synapses and GABA<inf>a</inf> receptor localization at inhibitory synapses are regulated by neuroplastin-65. Journal of Biological Chemistry. 289(13):8973-8988. Available from: 10.1074/jbc.M113.514992

    Happel MFK, Niekisch H, Castiblanco Rivera LL, Ohl FW, Deliano M, Frischknecht R. 2014. Enhanced cognitive flexibility in reversal learning induced by removal of the extracellular matrix in auditory cortex. Proceedings of the National Academy of Sciences of the United States of America. 111(7):2800-2805. Available from: 10.1073/pnas.1310272111

    Schott BH, Assmann A, Schmierer P, Soch J, Erk S, Garbusow M, Mohnke S, Pöhland L, Romanczuk-Seiferth N, Barman A, Wüstenberg T, Haddad L, Grimm O, Witt S, Richter S, Klein M, Schütze H, Mühleisen TW, Cichon S, Rietschel M, Noethen MM, Tost H, Gundelfinger ED, Düzel E, Heinz A, Meyer-Lindenberg A, Seidenbecher CI, Walter H. 2014. Epistatic interaction of genetic depression risk variants in the human subgenual cingulate cortex during memory encoding. Translational Psychiatry. 4(3). Available from: 10.1038/tp.2014.10

    Happel MFK, Deliano M, Handschuh J, Ohl FW. 2014. Dopamine-modulated recurrent corticoefferent feedback in primary sensory cortex promotes detection of behaviorally relevant stimuli. Journal of Neuroscience. 34(4):1234-1247. Available from: 10.1523/JNEUROSCI.1990-13.2014

    Morelli E, Ghiglieri V, Pendolino V, Bagetta V, Pignataro A, Fejtova A, Costa C, Ammassari-Teule M, Gundelfinger ED, Picconi B, Calabresi P. 2014. Environmental enrichment restores CA1 hippocampal LTP and reduces severity of seizures in epileptic mice. Experimental Neurology. 261:320-327. Available from: 10.1016/j.expneurol.2014.05.010

    Mawrin C, Seidenbecher C. 2014. Glioma and Extracellular Matrix. Sedo A, Mentlein R, editors. In Glioma Cell Biology. Vienna: Springer.

    Frischknecht R, Chang KJ, Rasband MN, Seidenbecher CI. 2014. Neural ECM molecules in axonal and synaptic homeostatic plasticity. Progress in Brain Research. 214:81-100. Available from: 10.1016/B978-0-444-63486-3.00004-9

    Tsilibary E, Tzinia A, Radenovic L, Stamenkovic V, Lebitko T, Mucha M, Pawlak R, Frischknecht R, Kaczmarek L. 2014. Neural ECM proteases in learning and synaptic plasticity. Progress in Brain Research. 214:135-157. Available from: 10.1016/B978-0-444-63486-3.00006-2

    Sakry D, Neitz A, Singh J, Frischknecht R, Marongiu D, Binamé F, Perera SS, Endres K, Lutz B, Radyushkin K, Trotter J, Mittmann T. 2014. Oligodendrocyte Precursor Cells Modulate the Neuronal Network by Activity-Dependent Ectodomain Cleavage of Glial NG2. PLoS Biology. 12(11). Available from: 10.1371/journal.pbio.1001993



    Lazarevic V, Pothula S, Andres-Alonso M, Fejtova A. 2013. Molecular mechanisms driving homeostatic plasticity of neurotransmitter release. Frontiers in Cellular Neuroscience. 7(DEC). Available from: 10.3389/fncel.2013.00244

    Regus-Leidig H, Ott C, Löhner M, Atorf J, Fuchs M, Sedmak T, Kremers J, Fejtová A, Gundelfinger ED, Brandstätter JH. 2013. Identification and Immunocytochemical Characterization of Piccolino, a Novel Piccolo Splice Variant Selectively Expressed at Sensory Ribbon Synapses of the Eye and Ear. PLoS ONE. 8(8). Available from: 10.1371/journal.pone.0070373

    Heine M, Karpova A, Gundelfinger ED. 2013. Counting gephyrins, one at a time: A nanoscale view on the inhibitory postsynapse. Neuron. 79(2):213-216. Available from: 10.1016/j.neuron.2013.07.004

    Sandoval M, Luarte A, Herrera-Molina R, Varas-Godoy M, Santibáñez M, Rubio FJ, Smit AB, Gundelfinger ED, Li KW, Smalla KH, Wyneken U. 2013. The glycolytic enzyme aldolase C is up-regulated in rat forebrain microsomes and in the cerebrospinal fluid after repetitive fluoxetine treatment. Brain Research. 1520:1-14. Available from: 10.1016/j.brainres.2013.04.049

    Kong M, Muñoz N, Valdivia A, Alvarez A, Herrera-Molina R, Cárdenas A, Schneider P, Burridge K, Quest AFG, Leyton L. 2013. Thy-1-mediated cell-cell contact induces astrocyte migration through the engagement of αVβ3 integrin and syndecan-4. Biochimica et Biophysica Acta - Molecular Cell Research. 1833(6):1409-1420. Available from: 10.1016/j.bbamcr.2013.02.013

    Richter A, Richter S, Barman A, Soch J, Klein M, Assmann A, Libeau C, Behnisch G, Wüstenberg T, Seidenbecher CI, Schott BH. 2013. Motivational salience and genetic variability of dopamine D2 receptor expression interact in the modulation of interference processing. Frontiers in Human Neuroscience. (MAY). Available from: 10.3389/fnhum.2013.00250

    Susuki K, Chang KJ, Zollinger DR, Liu Y, Ogawa Y, Eshed-Eisenbach Y, Dours-Zimmermann MT, Oses-Prieto JA, Burlingame AL, Seidenbecher CI, Zimmermann DR, Oohashi T, Peles E, Rasband MN. 2013. Three mechanisms assemble central nervous system nodes of ranvier. Neuron. 78(3):469-482. Available from: 10.1016/j.neuron.2013.03.005

    Waites CL, Leal-Ortiz SA, Okerlund N, Dalke H, Fejtova A, Altrock WD, Gundelfinger ED, Garner CC. 2013. Bassoon and Piccolo maintain synapse integrity by regulating protein ubiquitination and degradation. EMBO Journal. 32(7):954-969. Available from: 10.1038/emboj.2013.27

    Schroeder M, Stellmacher A, Romorini S, Marini C, Montenegro-Venegas C, Altrock WD, Gundelfinger ED, Fejtova A. 2013. Regulation of Presynaptic Anchoring of the Scaffold Protein Bassoon by Phosphorylation-Dependent Interaction with 14-3-3 Adaptor Proteins. PLoS ONE. 8(3). Available from: 10.1371/journal.pone.0058814

    Karpova A, Mikhaylova M, Bera S, Bär J, Reddy PP, Behnisch T, Rankovic V, Spilker C, Bethge P, Sahin J, Kaushik R, Zuschratter W, Kähne T, Naumann M, Gundelfinger ED, Kreutz MR. 2013. Encoding and transducing the synaptic or extrasynaptic origin of NMDA receptor signals to the nucleus. Cell. 152(5):1119-1133. Available from: 10.1016/j.cell.2013.02.002

    Matkovic T, Siebert M, Knoche E, Depner H, Mertel S, Owald D, Schmidt M, Thomas U, Sickmann A, Kamin D, Hell SW, Bürger J, Hollmann C, Mielke T, Wichmann C, Sigrist SJ. 2013. The bruchpilot cytomatrix determines the size of the readily releasable pool of synaptic vesicles. Journal of Cell Biology. 202(4):667-683. Available from: 10.1083/jcb.201301072

    Herrera-Molina R, Valdivia A, Kong M, Alvarez A, Cárdenas A, Quest AFG, Leyton L. 2013. Thy-1-interacting molecules and cellular signaling in Cis and Trans. International Review of Cell and Molecular Biology. 305:163-216. Available from: 10.1016/B978-0-12-407695-2.00004-4



    Seeger C, Gorny X, Reddy PP, Seidenbecher C, Danielson UH. 2012. Kinetic and mechanistic differences in the interactions between caldendrin and calmodulin with AKAP79 suggest different roles in synaptic function. Journal of Molecular Recognition. 25(10):495-503. Available from: 10.1002/jmr.2215

    Herrera-Molina R, Flores B, Orellana JA, Von Bernhardi R. 2012. Modulation of interferon-γ-induced glial cell activation by transforming growth factor β1: A role for STAT1 and MAPK pathways. Journal of Neurochemistry. 123(1):113-123. Available from: 10.1111/j.1471-4159.2012.07887.x

    Maas C, Torres VI, Altrock WD, Leal-Ortiz S, Wagh D, Terry-Lorenzo RT, Fejtova A, Gundelfinger ED, Ziv NE, Garner CC. 2012. Formation of Golgi-derived active zone precursor vesicles. Journal of Neuroscience. 32(32):11095-11108. Available from: 10.1523/JNEUROSCI.0195-12.2012

    Koch N, Dharmalingam E, Westermann M, Qualmann B, Thomas U, Kessels MM. 2012. Abp1 utilizes the Arp2/3 complex activator Scar/WAVE in bristle development. Journal of Cell Science. 125(15):3578-3589. Available from: 10.1242/jcs.101451

    Miró X, Meier S, Dreisow ML, Frank J, Strohmaier J, Breuer R, Schmäl C, Albayram Ö, Pardo-Olmedilla MT, Mühleisen TW, Degenhardt FA, Mattheisen M, Reinhard I, Bilkei-Gorzo A, Cichon S, Seidenbecher C, Rietschel M, Nöthen MM, Zimmer A. 2012. Studies in humans and mice implicate neurocan in the etiology of mania. American Journal of Psychiatry. 169(9):982-990. Available from: 10.1176/appi.ajp.2012.11101585

    Gorny X, Mikhaylova M, Seeger C, Reddy PP, Reissner C, Schott BH, Helena Danielson U, Kreutz MR, Seidenbecher C. 2012. AKAP79/150 interacts with the neuronal calcium-binding protein caldendrin. Journal of Neurochemistry. 122(4):714-726. Available from: 10.1111/j.1471-4159.2012.07828.x

    MacHaradze T, Pielot R, Wanger T, Scheich H, Gundelfinger ED, Budinger E, Goldschmidt J, Kreutz MR. 2012. Altered neuronal activity patterns in the visual cortex of the adult rat after partial optic nerve crush-a single-cell resolution metabolic mapping study. Cerebral Cortex. 22(8):1824-1833. Available from: 10.1093/cercor/bhr256

    Hodas JJL, Nehring A, Höche N, Sweredoski MJ, Pielot R, Hess S, Tirrell DA, Dieterich DC, Schuman EM. 2012. Dopaminergic modulation of the hippocampal neuropil proteome identified by bioorthogonal noncanonical amino acid tagging (BONCAT). Proteomics. 12(15-16):2464-2476. Available from: 10.1002/pmic.201200112

    Kähne T, Kolodziej A, Smalla KH, Eisenschmidt E, Haus UU, Weismantel R, Kropf S, Wetzel W, Ohl FW, Tischmeyer W, Naumann M, Gundelfinger ED. 2012. Synaptic proteome changes in mouse brain regions upon auditory discrimination learning. Proteomics. 12(15-16):2433-2444. Available from: 10.1002/pmic.201100669

    Frischknecht R, Seidenbecher CI. 2012. Brevican: A key proteoglycan in the perisynaptic extracellular matrix of the brain. International Journal of Biochemistry and Cell Biology. 44(7):1051-1054. Available from: 10.1016/j.biocel.2012.03.022

    Hübler D, Rankovic M, Richter K, Lazarevic V, Altrock WD, Fischer KD, Gundelfinger ED, Fejtova A. 2012. Differential spatial expression and subcellular localization of CtBP family members in Rodent Brain. PLoS ONE. 7(6). Available from: 10.1371/journal.pone.0039710

    Schmeisser MJ, Ey E, Wegener S, Bockmann J, Stempel AV, Kuebler A, Janssen AL, Udvardi PT, Shiban E, Spilker C, Balschun D, Skryabin BV, Dieck ST, Smalla KH, Montag D, Leblond CS, Faure P, Torquet N, Le Sourd AM, Toro R, Grabrucker AM, Shoichet SA, Schmitz D, Kreutz MR, Bourgeron T, Gundelfinger ED, Boeckers TM. 2012. Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2. Nature. 486(7402):256-260. Available from: 10.1038/nature11015

    Gundelfinger ED, Fejtova A. 2012. Molecular organization and plasticity of the cytomatrix at the active zone. Current Opinion in Neurobiology. 22(3):423-430. Available from: 10.1016/j.conb.2011.10.005

    Sarto-Jackson I, Milenkovic I, Smalla KH, Gundelfinger ED, Kaehne T, Herrera-Molina R, Thomas S, Kiebler MA, Sieghart W. 2012. The cell adhesion molecule neuroplastin-65 is a novel interaction partner of γ-aminobutyric acid type A receptors. Journal of Biological Chemistry. 287(17):14201-14214. Available from: 10.1074/jbc.M111.293175

    Herrera-Molina R, Frischknecht R, Maldonado H, Seidenbecher CI, Gundelfinger ED, Hetz C, de la Luz Aylwin M, Schneider P, Quest AFG, Leyton L. 2012. Astrocytic α vβ 3 integrin inhibits neurite outgrowth and promotes retraction of neuronal processes by clustering thy-1. PLoS ONE. 7(3). Available from: 10.1371/journal.pone.0034295

    Dieni S, Matsumoto T, Dekkers M, Rauskolb S, Ionescu MS, Deogracias R, Gundelfinger ED, Kojima M, Nestel S, Frotscher M, Barde YA. 2012. BDNF and its pro-peptide are stored in presynaptic dense core vesicles in brain neurons. Journal of Cell Biology. 196(6):775-788. Available from: 10.1083/jcb.201201038

    Schicknick H, Reichenbach N, Smalla KH, Scheich H, Gundelfinger ED, Tischmeyer W. 2012. Dopamine modulates memory consolidation of discrimination learning in the auditory cortex. European Journal of Neuroscience. 35(5):763-774. Available from: 10.1111/j.1460-9568.2012.07994.x

    Czöndör K, Mondin M, Garcia M, Heine M, Frischknecht R, Choquet D, Sibarita JB, Thoumine OR. 2012. Unified quantitative model of AMPA receptor trafficking at synapses. Proceedings of the National Academy of Sciences of the United States of America. 109(9):3522-3527. Available from: 10.1073/pnas.1109818109

    Chen Y, Yuanxiang P, Knöpfel T, Thomas U, Behnisch T. 2012. Hippocampal LTP triggers proteasome-mediated SPAR degradation in CA1 neurons. Synapse. 66(2):142-150. Available from: 10.1002/syn.20994

    Thomas U, Sigrist SJ. 2012. Glutamate receptors in synaptic assembly and plasticity: Case studies on fly NMJs. In Advances in Experimental Medicine and Biology. pp. 3-28. (Advances in Experimental Medicine and Biology). Available from: 10.1007/978-3-7091-0932-8_1

    Pielot R, Smalla KH, Müller A, Landgraf P, Lehmann AC, Eisenschmidt E, Haus UU, Weismantel R, Gundelfinger ED, Dieterich DC. 2012. Synprot: A database for proteins of detergent-resistant synaptic protein preparations. Frontiers in Synaptic Neuroscience. (JUN). Available from: 10.3389/fnsyn.2012.00001

    Frischknecht R, Gundelfinger ED. 2012. The brain's extracellular matrix and its role in synaptic plasticity. In Advances in Experimental Medicine and Biology. pp. 153-171. (Advances in Experimental Medicine and Biology). Available from: 10.1007/978-3-7091-0932-8_7



    Richter S, Gorny X, Marco-Pallares J, Krämer UM, Machts J, Barman A, Bernstein HG, Schüle R, Schöls L, Rodriguez-Fornells A, Reissner C, Wüstenberg T, Heinze HJ, Gundelfinger ED, Düzel E, Münte TF, Seidenbecher CI, Schott BH. 2011. A potential role for a genetic variation of AKAP5 in human aggression and anger control. Frontiers in Human Neuroscience. 5(DEC). Available from: 10.3389/fnhum.2011.00175

    Koch D, Spiwoks-Becker I, Sabanov V, Sinning A, Dugladze T, Stellmacher A, Ahuja R, Grimm J, Schüler S, Müller A, Angenstein F, Ahmed T, Diesler A, Moser M, Tom Dieck S, Spessert R, Boeckers TM, Fässler R, Hübner CA, Balschun D, Gloveli T, Kessels MM, Qualmann B. 2011. Proper synaptic vesicle formation and neuronal network activity critically rely on syndapin i. EMBO Journal. 30(24):4955-4969. Available from: 10.1038/emboj.2011.339

    Heyden A, Ionescu MCS, Romorini S, Kracht B, Ghiglieri V, Calabresi P, Seidenbecher C, Angenstein F, Gundelfinger ED. 2011. Hippocampal enlargement in Bassoon-mutant mice is associated with enhanced neurogenesis, reduced apoptosis, and abnormal BDNF levels. Cell and Tissue Research. 346(1):11-26. Available from: 10.1007/s00441-011-1233-3

    Sandoval R, González A, Caviedes A, Pancetti F, Smalla KH, Kaehne T, Michea L, Gundelfinger ED, Wyneken U. 2011. Homeostatic NMDA receptor down-regulation via brain derived neurotrophic factor and nitric oxide-dependent signalling in cortical but not in hippocampal neurons. Journal of Neurochemistry. 118(5):760-772. Available from: 10.1111/j.1471-4159.2011.07365.x

    Popiolek M, Ross JF, Charych E, Chanda P, Gundelfinger ED, Moss SJ, Brandon NJ, Pausch MH. 2011. D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone. Journal of Biological Chemistry. 286(33):28867-28875. Available from: 10.1074/jbc.M111.262063

    Lazarevic V, Schöne C, Heine M, Gundelfinger ED, Fejtova A. 2011. Extensive remodeling of the presynaptic cytomatrix upon homeostatic adaptation to network activity silencing. Journal of Neuroscience. 31(28):10189-10200. Available from: 10.1523/JNEUROSCI.2088-11.2011

    Grabrucker AM, Knight MJ, Proepper C, Bockmann J, Joubert M, Rowan M, Nienhaus GU, Garner CC, Bowie JU, Kreutz MR, Gundelfinger ED, Boeckers TM. 2011. Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation. EMBO Journal. 30(3):569-581. Available from: 10.1038/emboj.2010.336

    Blum R, Heinrich C, Sánchez R, Lepier A, Gundelfinger ED, Berninger B, Götz M. 2011. Neuronal network formation from reprogrammed early postnatal rat cortical glial cells. Cerebral Cortex. 21(2):413-424. Available from: 10.1093/cercor/bhq107

    Zweynert S, Pade JP, Wüstenberg T, Sterzer P, Walter H, Seidenbecher CI, Richardson-Klavehn A, Düzel E, Schott BH. 2011. Motivational salience modulates hippocampal repetition suppression and functional connectivity in humans. Frontiers in Human Neuroscience. 5:144. Available from: 10.3389/fnhum.2011.00144

    Pyka M, Busse C, Seidenbecher C, Gundelfinger ED, Faissner A. 2011. Astrocytes are crucial for survival and maturation of embryonic hippocampal neurons in a neuron-glia cell-insert coculture assay. Synapse. 65(1):41-53. Available from: 10.1002/syn.20816

    Gundelfinger ED. 2011. Im Netzwerk des Gehirns - von Genen, Synapsen und der Speicherung von Information. M. O, editor. In Web 3.0 - Wird es das Netz der Informationsspezialisten?: Beiblatt zum Tagungsband. DGI.



    Lau T, Schneidt T, Heimann F, Gundelfinger ED, Schloss P. 2010. Somatodendritic serotonin release and re-uptake in mouse embryonic stem cell-derived serotonergic neurons. Neurochemistry International. 57(8):969-978. Available from: 10.1016/j.neuint.2010.10.003

    Frank T, Rutherford MA, Strenzke N, Neef A, Pangršič T, Khimich D, Fejtová A, Gundelfinger ED, Liberman MC, Harke B, Bryan KE, Lee A, Egner A, Riedel D, Moser T. 2010. Bassoon and the synaptic ribbon organize Ca2+ channels and vesicles to add release sites and promote refilling. Neuron. 68(4):724-738. Available from: 10.1016/j.neuron.2010.10.027

    Fejtova A, Schmidt H, Weyhersmüller A, Silver RA, Gundelfinger ED, Eilers J. 2010. Bassoon speeds vesicle reloading at a central excitatory synapse. Neuron. 68(4):710-723. Available from: 10.1016/j.neuron.2010.10.026

    Dityatev A, Seidenbecher CI, Schachner M. 2010. Compartmentalization from the outside: The extracellular matrix and functional microdomains in the brain. Trends in Neurosciences. 33(11):503-512. Available from: 10.1016/j.tins.2010.08.003

    Thomas U, Kobler O, Gundelfinger ED. 2010. The Drosophila larval neuromuscular junction as a model for scaffold complexes at glutamatergic synapses: Benefits and limitations. Journal of Neurogenetics. 24(3):109-119. Available from: 10.3109/01677063.2010.493589

    Goswami C, Rademacher N, Smalla KH, Kalscheuer V, Ropers HH, Gundelfinger ED, Hucho T. 2010. TRPV1 acts as a synaptic protein and regulates vesicle recycling. Journal of Cell Science. 123(12):2045-2057. Available from: 10.1242/jcs.065144

    Buran BN, Strenzke N, Neef A, Gundelfinger ED, Moser T, Liberman MC. 2010. Onset coding is degraded in auditory nerve fibers from mutant mice lacking synaptic ribbons. Journal of Neuroscience. 30(22):7587-7597. Available from: 10.1523/JNEUROSCI.0389-10.2010

    Gundelfinger ED, Frischknecht R, Choquet D, Heine M. 2010. Converting juvenile into adult plasticity: A role for the brain's extracellular matrix. European Journal of Neuroscience. 31(12):2156-2165. Available from: 10.1111/j.1460-9568.2010.07253.x

    Lanore F, Blanchet C, Fejtova A, Pinheiro P, Richter K, Balschun D, Gundelfinger E, Mulle C. 2010. Impaired development of hippocampal mossy fibre synapses in mouse mutants for the presynaptic scaffold protein Bassoon. Journal of Physiology. 588(12):2133-2145. Available from: 10.1113/jphysiol.2009.184929

    Ghiglieri V, Sgobio C, Patassini S, Bagetta V, Fejtova A, Giampá C, Marinucci S, Heyden A, Gundelfinger ED, Fusco FR, Calabresi P, Picconi B. 2010. TrkB/BDNF-dependent striatal plasticity and behavior in a genetic model of epilepsy: Modulation by valproic acid. Neuropsychopharmacology. 35(7):1531-1540. Available from: 10.1038/npp.2010.23

    Faissner A, Pyka M, Geissler M, Sobik T, Frischknecht R, Gundelfinger ED, Seidenbecher C. 2010. Contributions of astrocytes to synapse formation and maturation - Potential functions of the perisynaptic extracellular matrix. Brain Research Reviews. 63(1-2):26-38. Available from: 10.1016/j.brainresrev.2010.01.001

    Bachmann A, Kobler O, Kittel RJ, Wichmann C, Sierralta J, Sigrist SJ, Gundelfinger ED, Knust E, Thomas U. 2010. A perisynaptic ménage à trois between Dlg, DLin-7, and metro controls proper organization of Drosophila synaptic junctions. Journal of Neuroscience. 30(17):5811-5824. Available from: 10.1523/JNEUROSCI.0778-10.2010

    Dondzillo A, Sätzler K, Horstmann H, Altrock WD, Gundelfinger ED, Kuner T. 2010. Targeted three-dimensional immunohistochemistry reveals localization of presynaptic proteins Bassoon and Piccolo in the rat calyx of held before and after the onset of hearing. Journal of Comparative Neurology. 518(7):1008-1029. Available from: 10.1002/cne.22260

    Sgobio C, Ghiglieri V, Costa C, Bagetta V, Siliquini S, Barone I, Di Filippo M, Gardoni F, Gundelfinger ED, Di Luca M, Picconi B, Calabresi P. 2010. Hippocampal Synaptic Plasticity, Memory, and Epilepsy: Effects of Long-Term Valproic Acid Treatment. Biological Psychiatry. 67(6):567-574. Available from: 10.1016/j.biopsych.2009.11.008

    Goetze B, Schmidt KF, Lehmann K, Altrock WD, Gundelfinger ED, Löwel S. 2010. Vision and visual cortical maps in mice with a photoreceptor synaptopathy: Reduced but robust visual capabilities in the absence of synaptic ribbons. NeuroImage. 49(2):1622-1631. Available from: 10.1016/j.neuroimage.2009.10.019

    Scharfe M, Pielot R, Schreiber F. 2010. Fast multi-core based multimodal registration of 2D cross-sections and 3D datasets. BMC Bioinformatics. 11. Available from: 10.1186/1471-2105-11-20

    Haucke V, Gundelfinger ED. 2010. Endocytosis and Presynaptic Scaffolds. In Encyclopedia of Neuroscience. Oxford: Academic Press. pp. 995-1006. Available from: 10.1016/B978-008045046-9.01782-4

    Schott BH, Frischknecht R, Debska-Vielhaber G, John N, Behnisch G, Düzel E, Gundelfinger ED, Seidenbecher CI. 2010. Membrane-bound catechol-O-methyl transferase in cortical neurons and glial cells is intracellularly oriented. Frontiers in Psychiatry. 1(OCT). Available from: 10.3389/fpsyt.2010.00142

  • Teaching & Internships

    Teaching & Internships

    We are involved in the education of students of the master's program "Integrative Neuroscience" at OVGU. Members of our department teach in the following subjects:

    • Cellular Neurophysiology
    • Basic Molecular and Cell Biology
    • Molecular and Cellular Biology
    • Genetic Models
    • Neural Signaling

    Furthermore, teaching for prospective physicians in biochemistry (Constanze Seidenbecher) as well as in various graduate programs is given.

    We also offer the following internship opportunities:

    • Lab rotations in the subjects listed above
    • Summer internships in Neurochemistry and Molecular Neurobiology
  • Our activities

    Our activities

Working Groups

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